ID A0A2I3SBV6_PANTR Unreviewed; 198 AA.
AC A0A2I3SBV6; A0A2J8Q0W6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Coatomer subunit zeta {ECO:0000256|RuleBase:RU366053};
GN Name=COPZ1 {ECO:0000313|Ensembl:ENSPTRP00000074528.1,
GN ECO:0000313|VGNC:VGNC:5344};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000074528.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000074528.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000074528.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: The zeta subunit may be involved in regulating the coat
CC assembly and, hence, the rate of biosynthetic protein transport due to
CC its association-dissociation properties with the coatomer complex.
CC {ECO:0000256|RuleBase:RU366053}.
CC -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC beta', gamma, delta, epsilon and zeta subunits.
CC {ECO:0000256|RuleBase:RU366053}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU366053}. Golgi
CC apparatus membrane {ECO:0000256|ARBA:ARBA00004255,
CC ECO:0000256|RuleBase:RU366053}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|RuleBase:RU366053};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004255,
CC ECO:0000256|RuleBase:RU366053}. Cytoplasmic vesicle, COPI-coated
CC vesicle membrane {ECO:0000256|RuleBase:RU366053}; Peripheral membrane
CC protein {ECO:0000256|RuleBase:RU366053}; Cytoplasmic side
CC {ECO:0000256|RuleBase:RU366053}.
CC -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC {ECO:0000256|ARBA:ARBA00006972, ECO:0000256|RuleBase:RU366053}.
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DR EMBL; AACZ04012943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3SBV6; -.
DR SMR; A0A2I3SBV6; -.
DR STRING; 9598.ENSPTRP00000074528; -.
DR Ensembl; ENSPTRT00000087382.1; ENSPTRP00000074528.1; ENSPTRG00000005037.5.
DR VGNC; VGNC:5344; COPZ1.
DR GeneTree; ENSGT00390000004405; -.
DR InParanoid; A0A2I3SBV6; -.
DR OMA; YDSHLAV; -.
DR Proteomes; UP000002277; Chromosome 12.
DR Bgee; ENSPTRG00000005037; Expressed in Brodmann (1909) area 10 and 20 other cell types or tissues.
DR GO; GO:0030126; C:COPI vesicle coat; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR CDD; cd14829; Zeta-COP; 1.
DR Gene3D; 3.30.450.60; -; 1.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR000804; Clathrin_sm-chain_CS.
DR InterPro; IPR039652; Coatomer_zeta.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR PANTHER; PTHR11043:SF2; COATOMER SUBUNIT ZETA-1; 1.
DR PANTHER; PTHR11043; ZETA-COAT PROTEIN; 1.
DR Pfam; PF01217; Clat_adaptor_s; 2.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS00989; CLAT_ADAPTOR_S; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU366053};
KW Cytoplasmic vesicle {ECO:0000256|RuleBase:RU366053};
KW ER-Golgi transport {ECO:0000256|RuleBase:RU366053};
KW Golgi apparatus {ECO:0000256|RuleBase:RU366053};
KW Membrane {ECO:0000256|RuleBase:RU366053};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU366053};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transport {ECO:0000256|RuleBase:RU366053}.
FT DOMAIN 12..106
FT /note="AP complex mu/sigma subunit"
FT /evidence="ECO:0000259|Pfam:PF01217"
FT DOMAIN 128..172
FT /note="AP complex mu/sigma subunit"
FT /evidence="ECO:0000259|Pfam:PF01217"
SQ SEQUENCE 198 AA; 22340 MW; 005E0E4A5A5F25D7 CRC64;
MEALILEPSL YTVKAILILD NDGDRLFAKY YDDTYPSVKE QKAFEKNIFN KTHRTDSEIA
LLEGLTVVYK SSIDLYFYVI GSSYENELML MAVLNCLFDS LSQMLRTGST QAGGLHESSS
RQAWATQKNV EKRALLENME GLFLAVDEIV DGGVILESDP QQVVHRVALR GEDVPLTEQT
VSQVLQSAKE QIKWSLLR
//
