ID A0A2I3SCM3_PANTR Unreviewed; 772 AA.
AC A0A2I3SCM3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Adhesion G protein-coupled receptor E1 {ECO:0000313|Ensembl:ENSPTRP00000074783.1};
GN Name=ADGRE1 {ECO:0000313|Ensembl:ENSPTRP00000074783.1,
GN ECO:0000313|VGNC:VGNC:6605};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000074783.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000074783.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000074783.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AACZ04041361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04041362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04041363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3SCM3; -.
DR Ensembl; ENSPTRT00000104906.1; ENSPTRP00000074783.1; ENSPTRG00000010379.6.
DR VGNC; VGNC:6605; ADGRE1.
DR GeneTree; ENSGT00940000161354; -.
DR Proteomes; UP000002277; Chromosome 19.
DR Bgee; ENSPTRG00000010379; Expressed in spleen and 9 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR001740; GPCR_2_EMR1-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011:SF449; ADHESION G PROTEIN-COUPLED RECEPTOR E1; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR01128; EMR1HORMONER.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023040};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..772
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014122881"
FT TRANSMEM 431..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 582..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 627..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..68
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 80..118
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 433..679
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 772 AA; 86040 MW; 8CB63792CF1F0A64 CRC64;
MRGFNLLLFW GCCVMHSWER HIRPTRKPNT KGNNCRDSTL CPAYATCTNT VDSYYCTCKR
GFLSSNGQNH FKGPGVQCKD IDECSQSPQP CGPNSSCKNL SGRYKCSCLH GFSSPTGNDW
VLGKLGNFSC TGNKDGNFSC QSNNLFVWVL FKCKEDMIPD KKQIQQCQEG TAVKPAYVSF
CAQINNIFSV LDKVCENKTT VVSLKNTTES FVPVLKQIST WTKFTKEETS SLATVFLESV
ESMTLASFWK PSANVTPAVR TEYLDIESKV INKECSEENV TLNLVAKGDK MKIGCSTIEE
SESTETTGVA FVSFVGMESV LSERFFQDHQ APLTTSEIKL KMNSRVVGGI MTGEKKDGFS
DPVIYTLENI QPKQKFERPI CVSWSTDVKG GRWTSFGCVI LEASETYTVC SCNQMANLAV
IMASGELTMD FSLYIISHVG IIISLVCLVL AIATFLLCRS IRNHNTYLHL HLCVCLLSAK
TLFLAGIHKT DNKTGCAIIA GFLHYLFLAC FFWMLVEAVI LFLMVRNLKV VNYFSSRNIK
MLHICAFGYG LPMLVVVISA SVQPQGYGMH NRCWLNTETG FIWSFLGPVC TVIVINSLLL
TWTLWILRQR LSSVNAEVST LKDTRLLTFK AFAQLFILGC SWVLGIFQIG PVAGVMAYLF
TIINSLQGAF IFLIHCLLNG QVREEYKRWI TGKTKPSSQS QTSRILLSSM PSASKTVRDC
MLPAGAGRGR CRPLGDTQLC HVLGTEWELR VPTLVSSWMK CGVEDWGFIC IY
//
