ID A0A2I3SF63_PANTR Unreviewed; 919 AA.
AC A0A2I3SF63;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Neuronal PAS domain protein 3 {ECO:0000313|Ensembl:ENSPTRP00000075132.1};
GN Name=NPAS3 {ECO:0000313|Ensembl:ENSPTRP00000075132.1,
GN ECO:0000313|VGNC:VGNC:3344};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000075132.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000075132.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000075132.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AACZ04059470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04059471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04059472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04059473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04059474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04059475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016781469.1; XM_016925980.1.
DR AlphaFoldDB; A0A2I3SF63; -.
DR Ensembl; ENSPTRT00000093089.1; ENSPTRP00000075132.1; ENSPTRG00000006249.6.
DR VGNC; VGNC:3344; NPAS3.
DR GeneTree; ENSGT00940000158051; -.
DR Proteomes; UP000002277; Chromosome 14.
DR Bgee; ENSPTRG00000006249; Expressed in Brodmann (1909) area 10 and 15 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19732; bHLH-PAS_NPAS3_PASD6; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR013655; PAS_fold_3.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR PANTHER; PTHR23043:SF30; NEURONAL PAS DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08447; PAS_3; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 21..74
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 140..204
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 321..376
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 644..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..528
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..599
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 919 AA; 99209 MW; 4DC5B8BDD4014981 CRC64;
MAPTKPSFQQ DPSRRERLQA LRKEKSRDAA RSRRGKENFE FYELAKLLPL PAAITSQLDK
ASIIRLTISY LKMRDFANQG DPPWNLRMEG PPPNTSVKGI QMWKSELCMR KTPCEVIGAQ
RRRSPSALAI EVFEAHLGSH ILQSLDGFVF ALNQEGKFLY ISETVSIYLG LSQVELTGSS
VFDYVHPGDH VEMAEQLGMK LPPGRGLLSQ GTAEDGASSA SSSSQSETPE PVESTSPSLL
TTDNTLERSF FIRMKSTLTK RGVHIKSSGY KVIHITGRLR LRVSLSHGRT VPSQIMGLVV
VAHALPPPTI NEVRIDCHMF VTRVNMDLNI IYCENRISDY MDLTPVDIVG KRCYHFIHAE
DVEGIRHSHL DLLNKGQCVT KYYRWMQKNG GYIWIQSSAT IAINAKNANE KNIIWVNYLL
SNPEYKDTPM DIAQLPHLPE KTSESSETSD SESDSKDTSG ITEDNENSKS DEKGNQSENS
EDPEPDRKKS GNACDNDMNC NDDGHSSSNP DSRDSDDSFE HSDFENPKAG EDGFGALGPM
QIKVERYVES ESDLRLQNCE SLTSDSAKDS DSAGEAGAQA SSKHQKRKKR RKRQKGGSAS
RRRLSSASSP GGLDAGLVEP PRLLSSPNSA SVLKIKTEIS EPINFDNDSS IWNYPPNREI
SRNESPYSMT KPPSSEHFPS PQGGGGGGGG GGGGLHVAIP DSVLTPPGAD GAAARKTQFG
ASATAALAPV ASDPLSPPLS ASPRDKHPGN GGGGGGGGAG GGGPSGSNSL LYTGDLEALQ
RLQAGNVVLP LVHRVTGTLA ATSTAAQRVY TTGTIRYAPA EVTLAMQSNL LPNAHAVNFV
DVNSPGFGLD PKTPMEMLYH HVHRLNMSGP FGGAVSAASL TQMPAGNVFT TAEGLFSTLP
FPVYSNGIHA AQTLERKED
//
