ID A0A2I3SGG6_PANTR Unreviewed; 616 AA.
AC A0A2I3SGG6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Formin like 1 {ECO:0000313|Ensembl:ENSPTRP00000075978.1};
GN Name=FMNL1 {ECO:0000313|Ensembl:ENSPTRP00000075978.1,
GN ECO:0000313|VGNC:VGNC:9283};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000075978.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000075978.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000075978.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family.
CC {ECO:0000256|ARBA:ARBA00023449}.
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DR EMBL; AACZ04061668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC185985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3SGG6; -.
DR Ensembl; ENSPTRT00000099316.1; ENSPTRP00000075978.1; ENSPTRG00000009300.6.
DR VGNC; VGNC:9283; FMNL1.
DR GeneTree; ENSGT00940000156292; -.
DR Proteomes; UP000002277; Chromosome 17.
DR Bgee; ENSPTRG00000009300; Expressed in lymph node and 19 other cell types or tissues.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR GO; GO:0022604; P:regulation of cell morphogenesis; IEA:InterPro.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR043592; FMNL_animal.
DR InterPro; IPR014768; GBD/FH3_dom.
DR PANTHER; PTHR45857; FORMIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR45857:SF2; FORMIN-LIKE PROTEIN 1; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00022707};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 1..172
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 277..616
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 148..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..262
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 616 AA; 68844 MW; 93BCC348A7377A97 CRC64;
GQLQGPQHRF EKLMEYFRNE DSNIDFMVAC MQFINIVVHS VENMNFRVFL QYEFTHLGLD
LYLERLRLTE SDKLQVQIQA YLDNIFDVGA LLEDTETKNA VLEHMEELQE QVALLTERLR
DAENESMAKI AELEKQLSQA RKELETLRER FSESTAMGAS RRPPEPEKAP PAAPTRPSAL
ELKVEELEEK GLIRILRGPG DAVSIEILPV AVATPSGGYA PTPGVPTDLP PPPPPPPPPP
PPGTDGPVPP PPPPPPPGGP PDALGRRDSE LGPGVKAKKP IQTKFRMPLL NWVALKPSQI
TGTVFTELND EKVLQELDMS DFEEQFKTKS QGPSLDLSAL KSKAAQKAPS KATLIEANRA
KNLAITLRKG NLGAERICQA IEAYDLQALG LDFLELLMRF LPTEYERSLI TRFEREQRPM
EELSEEDRFM LCFSRIPRLP ERMTTLTFLG NFPDTAQLLM PQLNAIIAAS MSIKSSDKLR
QILEIVLAFG NYMNSSKRGA AYGFRLQSLD ALLEMKSTDR KQTLLHYLVK VIAEKYPQLT
GFHSDLHFLD KAGSVSLDSV LADVRSLQRG LELTQREFVR QDDCMVLKEF LRANSPTMDK
LLADSKTAQA VPTGGL
//
