ID A0A2I3SHB9_PANTR Unreviewed; 347 AA.
AC A0A2I3SHB9;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Fibroblast growth factor receptor 1 {ECO:0000313|Ensembl:ENSPTRP00000076284.1};
GN Name=FGFR1 {ECO:0000313|Ensembl:ENSPTRP00000076284.1,
GN ECO:0000313|VGNC:VGNC:870};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000076284.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000076284.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000076284.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04065569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3SHB9; -.
DR Ensembl; ENSPTRT00000092496.1; ENSPTRP00000076284.1; ENSPTRG00000020176.7.
DR VGNC; VGNC:870; FGFR1.
DR GeneTree; ENSGT00940000155860; -.
DR Proteomes; UP000002277; Chromosome 8.
DR Bgee; ENSPTRG00000020176; Expressed in colon and 21 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd05857; IgI_2_FGFR; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR19890; FIBROBLAST GROWTH FACTOR RECEPTOR; 1.
DR PANTHER; PTHR19890:SF13; FIBROBLAST GROWTH FACTOR RECEPTOR; 1.
DR Pfam; PF07679; I-set; 2.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..347
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014192331"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 70..158
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 167..269
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 23..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..49
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 347 AA; 38860 MW; 0321345FA8D5C282 CRC64;
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ DALPSSEDDD DDDDDSSSEE KETDNTKPNR
MPVAPYWTSP EKMEKKLHAV PAAKTVKFKC PSSGTPNPTL RWLKNGKEFK PDHRIGGYKV
RYATWSIIMD SVVPSDKGNY TCIVENEYGS INHTYQLDVV ERSPHRPILQ AGLPANKTVA
LGSNVEFMCK VYSDPQPHIQ WLKHIEVNGS KIGPDNLPYV QILKTAGVNT TDKEMEVLHL
RNVSFEDAGE YTCLAGNSIG LSHHSAWLTV LEALEERPAV MTSPLYLEII IYCTGAFLIS
CMVGSVIVYK MKSGTKKSDF HSQMAVHKLA KSIPLRRQVT EICFKLV
//
