ID A0A2I3SHL5_PANTR Unreviewed; 152 AA.
AC A0A2I3SHL5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Metalloproteinase inhibitor 1 {ECO:0000256|ARBA:ARBA00013524};
DE AltName: Full=Tissue inhibitor of metalloproteinases 1 {ECO:0000256|ARBA:ARBA00030100};
GN Name=TIMP1 {ECO:0000313|Ensembl:ENSPTRP00000076487.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000076487.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000076487.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000076487.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protease inhibitor I35 (TIMP) family.
CC {ECO:0000256|ARBA:ARBA00011027}.
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DR EMBL; AC201954; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3SHL5; -.
DR Ensembl; ENSPTRT00000080594.1; ENSPTRP00000076487.1; ENSPTRG00000044804.1.
DR GeneTree; ENSGT00940000161081; -.
DR Proteomes; UP000002277; Chromosome X.
DR Bgee; ENSPTRG00000044804; Expressed in fibroblast and 21 other cell types or tissues.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.370.10; Tissue inhibitor of metalloproteinase-1. Chain B, domain 1; 1.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR001820; TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR InterPro; IPR027465; TIMP_C.
DR PANTHER; PTHR11844; METALLOPROTEASE INHIBITOR; 1.
DR PANTHER; PTHR11844:SF20; METALLOPROTEINASE INHIBITOR 1; 1.
DR Pfam; PF00965; TIMP; 1.
DR SMART; SM00206; NTR; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50189; NTR; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601820-3};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Metalloenzyme inhibitor {ECO:0000256|ARBA:ARBA00023215};
KW Metalloprotease inhibitor {ECO:0000256|ARBA:ARBA00022608};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 1..92
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 95..142
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 100..105
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 113..134
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
SQ SEQUENCE 152 AA; 17152 MW; EB5137873CBF438A CRC64;
MTSGKNLEWE DYMYKGFQAL GDAADIRFVY TPAMESVCGY FHRSHNRSEE FLIAGKLQDG
LLHITTCSFV APWNSLSLAQ RRGFTKTYTV GCEECTVFPC LSIPCKLQSG THCLWTDQLL
QGSEKGFQSR HLACLPREPG LCTWQSLRSQ IA
//
