ID A0A2I3SI49_PANTR Unreviewed; 1655 AA.
AC A0A2I3SI49;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Suppressor of glucose, autophagy associated 1 {ECO:0000313|Ensembl:ENSPTRP00000076575.1};
GN Name=MTCL2 {ECO:0000313|VGNC:VGNC:54156};
GN Synonyms=SOGA1 {ECO:0000313|Ensembl:ENSPTRP00000076575.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000076575.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000076575.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000076575.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04052781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPTRT00000087197.1; ENSPTRP00000076575.1; ENSPTRG00000013465.6.
DR VGNC; VGNC:54156; MTCL2.
DR GeneTree; ENSGT00950000182982; -.
DR Proteomes; UP000002277; Chromosome 20.
DR Bgee; ENSPTRG00000013465; Expressed in cerebellar cortex and 21 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0010506; P:regulation of autophagy; IEA:InterPro.
DR InterPro; IPR027882; DUF4482.
DR InterPro; IPR027881; SOGA.
DR PANTHER; PTHR15742:SF1; PROTEIN SOGA1; 1.
DR PANTHER; PTHR15742; UNCHARACTERIZED; 1.
DR Pfam; PF14818; DUF4482; 1.
DR Pfam; PF11365; SOGA; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 1065..1198
FT /note="DUF4482"
FT /evidence="ECO:0000259|Pfam:PF14818"
FT REGION 1..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1186..1215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1426..1450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1532..1557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1630..1655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 214..277
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 306..347
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 446..480
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 505..546
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 816..861
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1079..1113
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 99..113
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..173
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1199..1213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1655 AA; 183091 MW; CBF1776E2177F5B2 CRC64;
MEAPAAEPPV RGCGPQPAPA PERKKSHRAP SPARPKDVAG WSLAKGRRGP GPGSAVACSA
ASSARPDKKG RAVAPGARGA GVRVAGVRTG VRAKGRPRPG AGPRPPPPPP SLTDSSSEVS
DCASEEARLL GLELALSSDA ESAAGGPAGV RTGQPAQPAP SAQQPPRPPA SPDEPSVAAS
SVGSSRLPLS ASLAFSDLTE EMLDCGPSGL VRELEELRSE NDYLKDEIEE LRAEMLEMRD
VYMEEDVYQL QELRQQLDQA SKTCRILQYR LRKAERRSLR AAQTGQVDGE LIRGLEQDVK
VSKDISMRLH KELEVVEKKR ARLEEENEEL RQRLIETELA KQVLQTELER PREHSLKKRG
TRSLGKADKK TSVQEDSADL KCQLHFAKEE SALMCKKLTK LAKENDSMKE ELLKYRSLYG
DLDSALSAEE LADAPHSRET ELKVHLKLVE EEANLLSRRI VELEVENRGL RAEMDDMKDH
GGGCGGPEAR LAFSALGGGE CGESLAELRR HLQFVEEEAE LLRRSSAELE DQNKLLLNEL
AKFRSEHELD VALSEDSCSV LSEPSQEELA AAKLQIGELS GKVKKLQYEN RVLLSNLQRC
DLASCQSTRP MLETDAEAGD SAQCVPAPLG ETHESHEVRL CRAREAEVLP GLREQAALVS
KAIDVLVADA NGFTAGLRLC LDNECADFRL HEAPDNSEGP RDTKLIHAIL VRLSVLQQEL
NAFTRKADAV LGCSVKEQQE SFSSLPPLGS QGLSKEILLA KDLGSDFQPP DFRDLPEWEP
RIREAFRTGD LDSKPDPSRS FRPYRAEDND SYASEIKELQ LVLAEAHDSL RGLQEQLSQE
RQLRKEEADN FNQKMVQLKE DQQRALLRRE FELQSLSLQR RLEQKFWSQE KNMLVQESQQ
FKHNFLLLFM KLRWFLKRWR QGKVLPSEGD DFLEVNSMKE LYLLMEEEEI NAQHSDNKAC
TGDSWTQNTP NEYIKTLADM KVTLKELCWL LRDERRGLTE LQQQFAKAKA TWETERAELK
GHTSQMELKT GKGAGERAGP DWKAALQRER EEQQHLLAES YSAVMELTRQ LQISERNWSQ
EKLQLVERLQ GEKQQVEQQV KELQNRLSQV RSGLVSCSMP LVLWWPELTL PTRSEKIHDK
EAVSEVELGG NGLKRTKSVS SMSEFESLLD CSPYLAGGDA RGKKLPNNPA FGFVSSEPGD
PEKDTKEKPG LSSRDCNHLG ALACQDPPGR QMQRSYTAPD KTGIRVYYSP PVARRLGVPV
VHDKEGKIII EPGFLFTTAK PKESAEADGL AESSYGRWLC NFSRQRLDGG SAGSPSAAGP
GFPAALHDFE MSGNMSDDMK EITNCVRQAM RSGSLERKVK STSSQTVGLA SVGTQTIRTV
SVGLQTDPPR SSLHGKAWSP RSSSLVSVRS KQISSSLDKV HSRIERPCCS PKYGSPKLQR
RSVSKLDSSK DRSLWNLHQG KQNGSAWARS TTTRDSPVLR NINDGLSSLF SVVEHSGSTE
SVWKLGMSET RAKPEPPKYG IVQEFFRNVC GRAPSPTSSA GEEGTKKPEP LSPASYHQPE
GVARILNKKA AKLGSSEEVR LTMLPQVGKD GVLRDGDGAV VLPNEDAVCD CSTQSLTSCF
ARSSRSAIRH SPSKCRLHPS ESSWGGEERA LPPSE
//
