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Database: UniProt
Entry: A0A2I3SKL6_PANTR
LinkDB: A0A2I3SKL6_PANTR
Original site: A0A2I3SKL6_PANTR 
ID   A0A2I3SKL6_PANTR        Unreviewed;       716 AA.
AC   A0A2I3SKL6;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 8.
DE   SubName: Full=ADAM metallopeptidase domain 2 {ECO:0000313|Ensembl:ENSPTRP00000077561};
GN   Name=ADAM2 {ECO:0000313|Ensembl:ENSPTRP00000077561,
GN   ECO:0000313|VGNC:VGNC:11931};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000077561, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000077561, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000077561}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AACZ04065564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPTRT00000091453; ENSPTRP00000077561; ENSPTRG00000020185.
DR   VGNC; VGNC:11931; ADAM2.
DR   GeneTree; ENSGT00940000161961; -.
DR   Proteomes; UP000002277; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0007338; P:single fertilization; IEA:InterPro.
DR   CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR033958; ADAM2.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR034027; Reprolysin_adamalysin.
DR   PANTHER; PTHR11905:SF108; PTHR11905:SF108; 1.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   PRINTS; PR00289; DISINTEGRIN.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; SSF57552; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00068,
KW   ECO:0000256|SAAS:SAAS00877335};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAAS:SAAS01078504, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS01078486,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS01078482,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    716       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014167252.
FT   TRANSMEM    668    688       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      159    356       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN      365    454       Disintegrin. {ECO:0000259|PROSITE:
FT                                PS50214}.
FT   DOMAIN      593    626       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DISULFID    426    446       {ECO:0000256|PROSITE-ProRule:PRU00068}.
FT   DISULFID    616    625       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   716 AA;  80084 MW;  659875314DF9F9D8 CRC64;
     MWRVLFLLSG LGGLRMDSNF DSLPVQITVP EKIRSIIKEG IESQASYKIV IEGKPYTVNL
     MQKNFLPHNF RVYSYSGTGI MKPLDQDFQN FCHYQGYIEG YPKSVVMVST CTGLRGLLQF
     ENVSYGIKPL ESSVGFEHVI YQVKHKKADV SLYNEKDTES RDLSFKLQSV EYNHMGSDTT
     VVAQKIFQLI GLTNAIFVSF NITIILSSLE LWIDENKIAT TGEANELLHT FLRWKTSYLV
     LRPHDVAFLL VYREKSNYVG ATFQGKMCDA NYAGGVVLHP RIISLESLAV ILAQLLSLSM
     GITYDDINKC QCSGAVCIMN PEAIHFSGVK IFSNCSIEDF AHFISKQKSQ CLHNQPRLDP
     FFKKQAVCGN AKLEAGEECD CGTEQDCALI GETCCDIATC RFKAGSNCAE GPCCENCLFM
     SKGRMCRPSF EECDLPEYCN GSSASCPENH YVQTGHPCGL NQWICINGVC MSGDKQCTDT
     FGKEVEFGPS ECYSHLNSKT DVSGNCGISD SGYTQCEADN LQCGKLICKY VGKFLLQIPR
     ATIIYANISG HLCIAVEFAS DHADSQKMWI KDGTSCGSNK VCRNQRCVSS SYLGYDCTTD
     KCSNRGVCNN KKHCHCSASY LPPDCSVQSD LWPGGSIDSG NFPPVAIPAR LHERRYIENI
     YHSKPMRWPF FLFIPFFIIF CVLIAITVKV HFQRKKWRTE DYSSDEQPES ESEPKG
//
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