ID A0A2I3SL89_PANTR Unreviewed; 900 AA.
AC A0A2I3SL89;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 {ECO:0000256|ARBA:ARBA00016171};
DE AltName: Full=Membrane-associated guanylate kinase inverted 3 {ECO:0000256|ARBA:ARBA00033438};
GN Name=MAGI3 {ECO:0000313|Ensembl:ENSPTRP00000077264.1,
GN ECO:0000313|VGNC:VGNC:8069};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000077264.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000077264.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000077264.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR EMBL; AACZ04034344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04034345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04034346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04034347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04034348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04034349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC213067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3SL89; -.
DR Ensembl; ENSPTRT00000100883.1; ENSPTRP00000077264.1; ENSPTRG00000001121.7.
DR VGNC; VGNC:8069; MAGI3.
DR GeneTree; ENSGT00940000156496; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000001121; Expressed in lung and 21 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 4.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.42.10; -; 5.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR10316; MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR10316:SF10; MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 2.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 4.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 5.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 4.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..72
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 175..208
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 363..426
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 511..583
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 626..713
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 796..878
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 62..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..610
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 900 AA; 98786 MW; 93D7ECE0BAEA8D0E CRC64;
RHKPNREMGK DLNNHFTTEE IYMTSKCTTR APRDGEVPGV DYNFISVEQF KALEESGALL
ESGTYDGNFY GTPKPPAEPS PFQPDPVDQV LFDNEFDAES QRKRTTSVSK MERMDSSLPE
EEEDEDKEAI NGSGNAENRE RHSESSDWMK TVPSYNQTNS SMDFRNYMMR DETLEPLPKN
WEMAYTDTGM IYFIDHNTKT TTWLDPRLCK KAKAPEDCED GGRDSETYSI ILILLILSCD
VIVDINGNCV LGHTHADVVQ MFQLVPVNQY VNLTLCRGYP LPDDSEDPVV DIVAATPVIN
GQSLTKGETC MNPQDFKPGA MVLEQNGKSG HTLTGDGLNG PSDTSEQRIS MASSGSSQPE
LVTIPLIKGP KGFGFAIADS PTGQKVKMIL DSQWCQGLQK GDIIKEIYHQ NVQNLTHLQV
VEVLKQFPVG ADVPLLILRG GPPSPTKTAK MKTDKKENAG SLEAINEPIP QPMPFPPSII
RSGSPKLDPS EVYLKSKTLY EDKPPNTKDL DVFFEKQESG FGFRIYIGAI IPLGAAEKDG
RLRAADELMC IDGIPVKGKS HKQVLDLMTT AARNGHVLLT VRRKIFYGEK QPEDDSSQAF
ISTQNGSPRL NRAEVPARPA PQEPYDVVLQ RKENEGFGFV ILTSKNKPPP GVIPHKIGRV
IEGSPADRCG KLKVGDHISA VNGQSIVELS HDNIVQLIKD AGVTVTLTVI AEEEHHGPPS
GTNSARQSPA LQHRPMGQSQ ANHIPGDRSA LEGEIGKDVS TSYRHSWSDH KHLAQPDTAV
ISVVGSRHNQ SLGCYPVELE RGPRGFGFSL RGGKEYNMGL FILRLAEDGP AIKDGRIHVG
DQIVEINGEP TQGITHTRAI ELIQAGGNKV LLLLRPGTGL IPDHGLAPSG LCSYVKPEQH
//
