ID   A0A2I3SMI6_PANTR        Unreviewed;       278 AA.
AC   A0A2I3SMI6;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Type I cytokine receptor cytokine-binding domain-containing protein {ECO:0000259|Pfam:PF09240};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000078222.1, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000078222.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 5
CC       subfamily. {ECO:0000256|ARBA:ARBA00008159}.
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DR   AlphaFoldDB; A0A2I3SMI6; -.
DR   Ensembl; ENSPTRT00000108204.1; ENSPTRP00000078222.1; ENSPTRG00000046054.1.
DR   GeneTree; ENSGT00940000163802; -.
DR   InParanoid; A0A2I3SMI6; -.
DR   Proteomes; UP000002277; Unplaced.
DR   Bgee; ENSPTRG00000046054; Expressed in cerebellar cortex and 17 other cell types or tissues.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR   GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR   GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003532; Short_hematopoietin_rcpt_2_CS.
DR   InterPro; IPR015321; TypeI_recpt_CBD.
DR   Pfam; PF09240; IL6Ra-bind; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
DR   PROSITE; PS01356; HEMATOPO_REC_S_F2; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..278
FT                   /note="Type I cytokine receptor cytokine-binding domain-
FT                   containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014125741"
FT   TRANSMEM        204..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          41..137
FT                   /note="Type I cytokine receptor cytokine-binding"
FT                   /evidence="ECO:0000259|Pfam:PF09240"
SQ   SEQUENCE   278 AA;  31281 MW;  FD3AF9B7BDA721C0 CRC64;
     MHVKCALSCA ALVCTNIRVS CTWVYIVLHA VCGKTRAGAE NLTCWIHDVD FLSCSWAVGP
     AAPADVQYDL YLNVANRRQQ YECLHYKTDA QGTRIGCRFD DISRLSSGSQ SCHILVRGRS
     AAFGIPCTDK FVVFSQIGDS YSIAHWYGKM RSGILRLFYL YFHEPHTCPI LLFFSTQVRD
     RTPCRTPPAL GEWCDQEEGA NTRAWQTSLL IALGTLLALV CVFLICRRYL LIQRLYPPHP
     SHDKTRSADS FQIRQSVCCA KAGLEECLVT EVQVVQKT
//