ID A0A2I3SMJ1_PANTR Unreviewed; 360 AA.
AC A0A2I3SMJ1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=EI24 autophagy associated transmembrane protein {ECO:0000313|Ensembl:ENSPTRP00000077721.1};
GN Name=EI24 {ECO:0000313|Ensembl:ENSPTRP00000077721.1,
GN ECO:0000313|VGNC:VGNC:8162};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000077721.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000077721.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000077721.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the EI24 family.
CC {ECO:0000256|ARBA:ARBA00010970}.
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DR EMBL; AACZ04006711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3SMJ1; -.
DR Ensembl; ENSPTRT00000077270.1; ENSPTRP00000077721.1; ENSPTRG00000004444.6.
DR VGNC; VGNC:8162; EI24.
DR GeneTree; ENSGT00390000018633; -.
DR InParanoid; A0A2I3SMJ1; -.
DR Proteomes; UP000002277; Chromosome 11.
DR Bgee; ENSPTRG00000004444; Expressed in liver and 21 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0061676; F:importin-alpha family protein binding; IEA:Ensembl.
DR GO; GO:0016236; P:macroautophagy; IBA:GO_Central.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR PANTHER; PTHR21389:SF0; ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG; 1.
DR PANTHER; PTHR21389; P53 INDUCED PROTEIN; 1.
DR Pfam; PF07264; EI24; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 95..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 339..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 360 AA; 41449 MW; FBDEE992F1A699A2 CRC64;
MADSVKTFLQ DLAREFISRP FFFLLKEPSR KSFRGIKDSI WGICTISKLD ARIQQKREEQ
RRRRASSVLA QRRAQSIERK QESEPRIVSR IFQCCAWNGG VFWFSLLLFY RVFIPVLQSV
TARIIGDPSL HGDVWSWLEF FLTSIFSALW VLPLFVLSKV VNAIWFQDIA DLAFEVSGRK
PHPFPSVSKI IADMLFNLLL QALFLIQGMF VSLFPIHLVG QLVSLLHMSL LYSLYCFEYR
WFNKGIEMHQ RLSNIERNWP YYFGFGLPLA FLTAMQSSYI ISGCLFSILF PLFIISANEA
KTPGKAYLFQ LRLFSLVVFL SNRLFHKTVY LQSALSSSTS AEKFPSPHPS PAKLKAAAGH
//
