ID A0A2I3SMU4_PANTR Unreviewed; 1113 AA.
AC A0A2I3SMU4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=MCF2L {ECO:0008006|Google:ProtNLM};
GN Name=MCF2L {ECO:0000313|Ensembl:ENSPTRP00000078359.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000078359.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000078359.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000078359.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AACZ04072779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04072780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04072781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04072782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC161613; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3SMU4; -.
DR PaxDb; 9598-ENSPTRP00000053323; -.
DR Ensembl; ENSPTRT00000077969.1; ENSPTRP00000078359.1; ENSPTRG00000006048.6.
DR GeneTree; ENSGT00940000157874; -.
DR Proteomes; UP000002277; Chromosome 13.
DR Bgee; ENSPTRG00000006048; Expressed in cerebellar cortex and 19 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01227; PH_Dbs; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd11857; SH3_DBS; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR035534; DBS_PH.
DR InterPro; IPR035532; DBS_SH3.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR22826:SF115; GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF00435; Spectrin; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..182
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 589..769
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 787..903
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1013..1074
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 516..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 927..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1074..1113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..953
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1113 AA; 125106 MW; 2F11CE15D35A8C97 CRC64;
MRFWLRTEEM ALEEMVQRLN AVSKHTDEIM HSTLVPLCAD QLKKRFAYLS RLSFQSRVGG
FRGQPASHLH TLTAASLPHC SLQDAGIGFI LVIDRRRDKW TSVKASVLRI AASFPANLQL
VLVLRPTGFF QRTLSDIAFK FNRDDFKMKV PVIMLSSVPD LHGYIDKSQL TEDLGGTLDY
CHSRWLCQRT AIESFALMVK QTAQMLQSFG TELAETELPN DVQSTSSVLC AHTEKKDKAK
EDLRLALKEG HSVLESLREL QAEGSEPSVN QDQLDNQATV QRLLTQLNET EAAFDEFWAK
HQQKLEQCLQ LRHFEQGFRE VKAILDAASQ KIATFTDIGN SLAHVEHLLR DLASFEEKSG
VAVERARALS LDGEQLIGNK HYAVDSIRPK CQELRHLCDQ FSAEIARRRG LLSKSLELHR
RLETSMKWCD EGIYLLASQP VDKCQSQDGA EAALQEIEKF LETGAENKIQ ELNAIYKEYE
SILNQDLMEH VRKVFQKQAS MEEVFHRRQA SLKKLAARQM RPVQPVAPRP EALAKSPCPS
PGIRRGSENS SSEGGALRRG PYRRAKSEMS ESRQGRGSAG EEEESLAILR RHVMSELLDT
ERAYVEELLC VLEGYAAEMD NPLMAHLLST GLHNKKDVLF GNMEEIYHFH NRIFLRELEN
YTDCPELVGR CFLERMEDFQ IYEKYCQNKP RSESLWRQCS DCPFFQECQR KLDHKLSLDS
YLLKPVQRIT KYQLLLKEML KYSRNCEGAE DLQEALSSIL GILKAVNDSM HLIAITGYDG
NLGDLGKLLM QGSFSVWTDH KRGHTKVKEL ARFKPMQRHL FLHEKAVLFC KKREENGEGY
EKAPSYSYKQ SLNMAAVGIT ENVKGDAKKF EIWYNAREEV YIVQAPTPEI KAAWVNEIRK
VLTSQLQACR GEAVFKRLFP VASAPGAFLP RSDPSRGNSR NIKKLEERKT DPLSLEGYVN
SAPLTKPPEK GKGWSKTSHS LEAPEDDGGW SSAEEQINSS DAEEDGGLGP KKLVPGKYTV
VADHEKGGPD ALLVRSGDVV ELVQEGDEGL WYVRDPTTGK EGWVPASSLS VQLGPSGSAQ
CLSSSESSPG SAVLSNSSSC SEGGQAPFSD LQG
//
