ID A0A2I3SNL8_PANTR Unreviewed; 1244 AA.
AC A0A2I3SNL8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Par-3 family cell polarity regulator {ECO:0000313|Ensembl:ENSPTRP00000078518.1};
GN Name=PARD3 {ECO:0000313|Ensembl:ENSPTRP00000078518.1,
GN ECO:0000313|VGNC:VGNC:7854};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000078518.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000078518.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000078518.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}.
CC -!- SIMILARITY: Belongs to the PAR3 family.
CC {ECO:0000256|ARBA:ARBA00005358}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04070686; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04070687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC183544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001144818.3; XM_001144818.4.
DR AlphaFoldDB; A0A2I3SNL8; -.
DR Ensembl; ENSPTRT00000076426.1; ENSPTRP00000078518.1; ENSPTRG00000002415.7.
DR GeneID; 450398; -.
DR CTD; 56288; -.
DR VGNC; VGNC:7854; PARD3.
DR GeneTree; ENSGT00950000183214; -.
DR OrthoDB; 5405986at2759; -.
DR Proteomes; UP000002277; Chromosome 10.
DR Bgee; ENSPTRG00000002415; Expressed in colon and 22 other cell types or tissues.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 3.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR16484:SF10; PARTITIONING DEFECTIVE 3 HOMOLOG; 1.
DR PANTHER; PTHR16484; PARTITIONING DEFECTIVE 3 RELATED; 1.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR Pfam; PF00595; PDZ; 3.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR PROSITE; PS50106; PDZ; 3.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 227..303
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 417..502
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 533..608
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 81..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 766..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 857..948
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 999..1244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..943
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1037..1066
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1091
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1103..1155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1173..1188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1244 AA; 138329 MW; 963150892C149389 CRC64;
MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD
LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ
ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL
KQNTAGSPKT CDRKDEDGTE EDNSRVEPVG HADTGLEHIP NFSLDDMVKL VEVPNDGGPL
GIHVVPFSAR GGRTLGLLVK RLEKGGKAEH ENLFHENDCI VRINDGDLRN RRFEQAQHMF
RQAMRTPIIW FHVVPAANKE QYEQLSQSEK NNYYSSRFSP DSQYIDNRSV NSAGLHTVQR
ASRLNHPPEQ IDSHSRLPHS AHPSGKPPSA PASAPQNVFS TTVSSGYNTK KIGKRLNIQL
KKGTEGLGFS ITSRDVTIGG SAPIYVKNIL PRGAAIQDGR LKAGDRLIEV NGVDLVGKSQ
EEVVSLLRST KMEGTVSLLV FRQEDAFHPR ELKPEDEDIV LTPDGTREFL TFEVPLNDSG
SAGLGVSVKG NRSKENHADL GIFVKSIING GAASKDGRLR VNDQLIAVNG ESLLGKTNQD
AMETLRRSMS TEGNKRGMIQ LIVARRISKC NELKSPGSPP GPELPIETAL DDRERRISHS
LYSGIEGLDE SPSRNAALSR IMGKYQLSPT VNMPQDDTVI IEDDRLPVLP PHLSDQSSSS
SHDDVGFVTA DAGTWAKAAI SDSADCSLSP DVDPVLAFQR EGFGRQSMSE KRTKQFSDAS
QLDFVKTRKS KSMDLGSSPS RDVGPSLGLK KSSSLESLQT AVAEVTLNGD IPFHRPRPRI
IRGRGCNESF RAAIDKSYDK PAVDDDDEGM ETLEEDTEES SRSGRESVST ASDQPSHSLE
RQMNGNQEKG DKTDRKKDKT GKEKKKDRDK EKDKMKAKKG MLKGLGDMFR IQAKTREFRE
RQARERDYAE IQDFHRTFGC DDELMYGGVS SYEGSMALNA RPQSPREGHM MDALYAQVKK
PRNSKPSPVD SNRSTPSNHD RIQRLRQEFQ QAKQDEDVED RRRTYSFEQP WPNARPATQS
GRHSVSVEVQ MQRQRQEERE SSQQAQRQYS SLPRQSRKNA SSVSQDSWEQ NYSPGEGFQS
AKENPRYSSY QGSRNGYLGG HGFNARVMLE TQELLRQEQR RKEQQMKKQP PSEGPSNYDS
YKKVQDPSYA PPKGPFRQDV PPSPSQVARL NRLQTPEKGR PFYS
//
