ID A0A2I3SNY0_PANTR Unreviewed; 670 AA.
AC A0A2I3SNY0; A0A2J8MNX4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Rho GTPase activating protein 28 {ECO:0000313|Ensembl:ENSPTRP00000078675.1};
GN Name=ARHGAP28 {ECO:0000313|Ensembl:ENSPTRP00000078675.1,
GN ECO:0000313|VGNC:VGNC:14783};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000078675.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000078675.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000078675.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04065229; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3SNY0; -.
DR Ensembl; ENSPTRT00000083222.1; ENSPTRP00000078675.1; ENSPTRG00000009847.7.
DR VGNC; VGNC:14783; ARHGAP28.
DR GeneTree; ENSGT00940000158929; -.
DR Proteomes; UP000002277; Chromosome 18.
DR Bgee; ENSPTRG00000009847; Expressed in testis and 15 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04391; RhoGAP_ARHGAP18; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF5; RHO GTPASE-ACTIVATING PROTEIN 28; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 328..525
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 670 AA; 75707 MW; A680107FAD5046F6 CRC64;
MLSNESLHPP AFSRSNSEAS VDSASMEDFW REIESIKDSS MGGQEEPPPA EVTPVDEGEL
EAEWLQDVGL STLISGDEEE DGKALLSTLT RTQAAAVEKR YNTYTQTMRK KNKQSIRDVR
DIFGVSESPP RDTCGNHTNQ LDGTKEEREL PRVIKTSGSM PDDASLNSTT LSDASQDKEG
SFAVPRSDSV AILETIPVVP VHSNGSPEPG QPVQNAISDD DFLEKNIPPE AEELSFEVSY
SEMVTEALKR NKLKKSEIKK EDYVLTKFNV QKTRFGLTEA GDLSAEDMKK IRHLSLIELT
AFFDAFGIQL KRNKTEKVKG RDNGIFGVPL TVLLDSDRKK DAGVKVPLVL QKFFEKVEES
GLESEGIFRL SGCTAKVKQY REELDAKFNA DKFKWDKMCH REAAVMLKAF FRELPTSLFP
VEYIPAFISL MERGPHVKVQ FQALHLMVMA LPDANRDAAQ ALMTFFNKVI ANESKNRMSL
WNISTVMAPN LFFSRSKHSD YEELLLANTA AHIIRLMLKY QKILWKVPSF LITQVRRMNE
ATMLLKKQLP SVRKLLRRKT LERETASPKT SKVLQKSPSA RRMSDVPEGV IRVHAPLLSK
VSMAIQLNNQ TKAKDILAKF QYENRILHWQ RAALSFLNGK WVKKEREEST EANRSPKHVF
LFTIGLDIST
//
