ID A0A2I3SPE9_PANTR Unreviewed; 384 AA.
AC A0A2I3SPE9;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Thyrotropin releasing hormone degrading enzyme {ECO:0000313|Ensembl:ENSPTRP00000078904.1};
GN Name=TRHDE {ECO:0000313|Ensembl:ENSPTRP00000078904.1,
GN ECO:0000313|VGNC:VGNC:8586};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000078904.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000078904.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000078904.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M1 family.
CC {ECO:0000256|ARBA:ARBA00010136}.
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DR EMBL; AACZ04071996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04071997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04071998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04071999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04072000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04072001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3SPE9; -.
DR Ensembl; ENSPTRT00000083774.1; ENSPTRP00000078904.1; ENSPTRG00000005230.6.
DR VGNC; VGNC:8586; TRHDE.
DR GeneTree; ENSGT00940000155878; -.
DR Proteomes; UP000002277; Chromosome 12.
DR Bgee; ENSPTRG00000005230; Expressed in temporal lobe and 13 other cell types or tissues.
DR Gene3D; 1.25.50.20; -; 1.
DR Gene3D; 2.60.40.1910; -; 1.
DR InterPro; IPR024571; ERAP1-like_C_dom.
DR PANTHER; PTHR11533; PROTEASE M1 ZINC METALLOPROTEASE; 1.
DR PANTHER; PTHR11533:SF40; THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME; 1.
DR Pfam; PF11838; ERAP1_C; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 91..363
FT /note="ERAP1-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11838"
SQ SEQUENCE 384 AA; 44565 MW; 5240D0FFA859037E CRC64;
MDQWTLQMGY PVITILGNTT AENRIIITQQ HFIYDISAKT KALKLQNNSY LWQIPLTIVV
GNRSHVSSEA IIWVSNKSEH HRITYLDKGS WLLGNINQTG YFRVNYDLRN WRLLIDQLIR
NHEVLSVSNR AGLIDDAFSL ARAGYLPQNI PLEIIRYLSE EKDFLPWHAA SRALYPLDKL
LDRMENYNIF NEYILKQVAT TYIKLGWPKN NFNGSLVQAS YQHEELRREV IMLACSFGNK
HCHQQASTLI SDWISSNRNR IPLNVRDIVY CTGVSLLDED VWEFIWMKFH STTAVSEKKI
LLEALTCSDD RNLLNRLLNL SLNSEVVLDQ DAIDVIIHVA RNPHGRDLAW KFFRDKWKIL
NTSCSKIYSQ DILFHGENSL ASIL
//
