ID A0A2I3SRI6_PANTR Unreviewed; 547 AA.
AC A0A2I3SRI6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Homeobox and leucine zipper encoding {ECO:0000313|Ensembl:ENSPTRP00000079636.1};
GN Name=HOMEZ {ECO:0000313|Ensembl:ENSPTRP00000079636.1,
GN ECO:0000313|VGNC:VGNC:3406};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000079636.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000079636.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000079636.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
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DR EMBL; AACZ04059395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3SRI6; -.
DR Ensembl; ENSPTRT00000090695.1; ENSPTRP00000079636.1; ENSPTRG00000052103.1.
DR VGNC; VGNC:3406; HOMEZ.
DR GeneTree; ENSGT00950000182893; -.
DR Proteomes; UP000002277; Chromosome 14.
DR Bgee; ENSPTRG00000052103; Expressed in testis and 18 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd00086; homeodomain; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 3.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR024578; Homez_homeobox_dom.
DR PANTHER; PTHR15467:SF7; HOMEOBOX AND LEUCINE ZIPPER PROTEIN HOMEZ; 1.
DR PANTHER; PTHR15467; ZINC-FINGERS AND HOMEOBOXES RELATED; 1.
DR Pfam; PF11569; Homez; 1.
DR SMART; SM00389; HOX; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS50071; HOMEOBOX_2; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 69..108
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 353..413
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 71..109
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 355..414
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..464
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 60798 MW; 8D2497D8730D940D CRC64;
GGGGCSEPRS RHSISEGHKS ESTMPPNKEA SGLSSSPAGL ICLPPISEEL QLVWTQAAQT
SELDSNEHLL KTFSYFPYPS LADIALLCLR YGLQMEKVKT WFMAQRLRCG ISWSSEEIEE
TRARVVYRRD QLHFKSLLSF THHAGRPPEE VPPPPMPAPE QVGIGIGPPT LSKPTQTKGL
KVEPEESSQM PPLPQSHQKL KESLMTPGSG AFPHQSDFWQ HLQSSGLSKE QAGRGPSQSH
GIGTASWNHS TTVPQPQAWD KPPPIALIAS SCKEESASSV TPSSSSTSSS FQVLANGATA
ASKPLQPLGC VPQSVSPSEQ ALPPHLEPAW PQGLRHNSIP GRVGPTEYLS PDMQRQRKTK
RKTKEQLAIL KSFFLQCQWA RREDYQKLEQ ITGLPRPEII QWFGDTRYAL KHGQLKWFRD
NAVPGAPSFQ DPAIPTPPPS TRSLNERAET PPLPIPPPPP DIQPLERYWA AHQQLRETDI
PQLSQASRLS TQQVLDWFDS RLPQPAEVVV CLDEEEEEEE EELPEDDEEE EEEEEDDDDD
DDVIIQD
//
