ID A0A2I3SRJ6_PANTR Unreviewed; 497 AA.
AC A0A2I3SRJ6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Calcium voltage-gated channel auxiliary subunit beta 4 {ECO:0000313|Ensembl:ENSPTRP00000079157.1};
GN Name=CACNB4 {ECO:0000313|Ensembl:ENSPTRP00000079157.1,
GN ECO:0000313|VGNC:VGNC:116};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000079157.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000079157.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000079157.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the calcium channel beta subunit family.
CC {ECO:0000256|ARBA:ARBA00010836}.
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DR EMBL; AACZ04058395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04058396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3SRJ6; -.
DR Ensembl; ENSPTRT00000083369.1; ENSPTRP00000079157.1; ENSPTRG00000047916.1.
DR VGNC; VGNC:116; CACNB4.
DR GeneTree; ENSGT00950000182837; -.
DR OMA; AMMERAN; -.
DR Proteomes; UP000002277; Chromosome 2B.
DR Bgee; ENSPTRG00000047916; Expressed in temporal lobe and 17 other cell types or tissues.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR CDD; cd12043; SH3_CACNB4; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR046937; CAB1-4_N_A-dom.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR000584; VDCC_L_bsu.
DR PANTHER; PTHR11824; VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT; 1.
DR PANTHER; PTHR11824:SF7; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF12052; VGCC_beta4Aa_N; 1.
DR PRINTS; PR01626; LCACHANNELB.
DR SMART; SM00072; GuKc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 45..114
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..478
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 497 AA; 55993 MW; 153D82B695B44C1C CRC64;
MAGSADSYTS RPSDSDVSLE EDREAIRQER EQQAAIQLER AKSKPVAFAV KTNVSYCGAL
DEDVPVPSTA ISFDAKDFLH IKEKYNNDWW IGRLVKEGCE IGFIPSPLRL ENIRIQQEQK
RGRFHGGYVP IFSIESLVPF LYPRKSSGNS SSSLGEMVSG TFRATPTGML NLTLSRVSNH
LFQTEHIPPY DVVPSMRPVV LVGPSLKGYE VTDMMQKALF DFLKHRFDGR ISITRVTADI
SLAKRSVLNN PSKRAIIERS NTRSSLAEVQ SEIERIFELA RSLQLVVLDA DTINHPAQLI
KTSLAPIIVH VKVSSPKVLQ RLIKSRGKSQ SKHLNVQLVA ADKLAQCPPE MFDVILDENQ
LEDACEHLGE YLEAYWRATH TTSSTPMTPL LGRNLGSTAL SPYPTAISGL QSQRMRHSNH
STENSPIERR SLMTSDENYH NERARKSRNR LSSSSQHSRD HYPLVEEDYP DSYQDTYKPH
RNRGSPGGYS HDSRHRL
//
