ID A0A2I3SS26_PANTR Unreviewed; 747 AA.
AC A0A2I3SS26;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Cysteine--tRNA ligase, cytoplasmic {ECO:0000256|ARBA:ARBA00039362};
DE EC=6.1.1.16 {ECO:0000256|ARBA:ARBA00012832};
DE AltName: Full=Cysteinyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00031499};
GN Name=CARS1 {ECO:0000313|Ensembl:ENSPTRP00000079343.1,
GN ECO:0000313|VGNC:VGNC:11276};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000079343.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000079343.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000079343.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the ATP-dependent ligation of cysteine to
CC tRNA(Cys). {ECO:0000256|ARBA:ARBA00037196}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-
CC cysteinyl-tRNA(Cys); Xref=Rhea:RHEA:17773, Rhea:RHEA-COMP:9661,
CC Rhea:RHEA-COMP:9679, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:35235, ChEBI:CHEBI:78442, ChEBI:CHEBI:78517,
CC ChEBI:CHEBI:456215; EC=6.1.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00036537};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17774;
CC Evidence={ECO:0000256|ARBA:ARBA00036537};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR EMBL; AACZ04062768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3SS26; -.
DR Ensembl; ENSPTRT00000086288.1; ENSPTRP00000079343.1; ENSPTRG00000003188.6.
DR VGNC; VGNC:11276; CARS1.
DR GeneTree; ENSGT00390000006347; -.
DR Proteomes; UP000002277; Chromosome 11.
DR Bgee; ENSPTRG00000003188; Expressed in fibroblast and 21 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004817; F:cysteine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006423; P:cysteinyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00672; CysRS_core; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR HAMAP; MF_00041; Cys_tRNA_synth; 1.
DR InterPro; IPR015803; Cys-tRNA-ligase.
DR InterPro; IPR024909; Cys-tRNA/MSH_ligase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR032678; tRNA-synt_1_cat_dom.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR NCBIfam; TIGR00435; cysS; 1.
DR PANTHER; PTHR10890:SF3; CYSTEINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR10890; CYSTEINYL-TRNA SYNTHETASE; 1.
DR Pfam; PF01406; tRNA-synt_1e; 1.
DR PRINTS; PR00983; TRNASYNTHCYS.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 43..451
FT /note="tRNA synthetases class I catalytic"
FT /evidence="ECO:0000259|Pfam:PF01406"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..678
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 747 AA; 85452 MW; CD8A4FA8C1277886 CRC64;
LLDHSGQGKG RRVQPQWSPP AGTQPCRLHL YNSLTRNKEV FIPQDGKKVT WYCCGPTVYD
ASHMGHARSY ISFDILRRVL KDYFKFDVFY CMNITDIDDK IIKRARQNHL FEQYREKRPE
AAQLLEDVQA ALKPFSVKLN ETTDPDKKQM LERIQHAVQL ATEPLEKAVQ SRLTGEEVNS
CVEVLLEEAK DLLSDWLDST LGCDVTDNSI FSKLPKFWEG DFHRDMEALN VLPPDVLTRV
SEYVPEIVNF VQKIVDNGYG YVSNGSVYFD TAKFASSEKH SYGKLVPEAV GDQKALQEGE
GDLSISADRL SEKRSPNDFA LWKASKPGEP SWPCPWGKGR PGWHIECSAM AGTLLGASMD
IHGGGFDLRF PHHDNELAQS EAYFENDCWV RYFLHTGHLT IAGCKMSKSL KNFITIKDAL
KKHSARQLRL AFLMHSWKDT LDYSSNTMES ALQYEKFLNE FFLNVKDILR APVDITGQFE
KWGEEEAELN KNFYDKKTAI HKALCDNVDT RTVMEEMRAL VSQCNLYMAA RKAMRKRPNQ
ALLENIALYL THMLKIFGAV EEDSSLGFPV GGPGTSLSLE ATVMPYLQVL SEFREGVRKI
AREQKVPEIL QLSDALRDDI LPELGVRFED HEGLPTVVKL VDRNTLLKER EEKRRVEEEK
RKKKEEAARR KQEQEAAKLA KMKIPPSEMF LSETDKYSKF DENGLPTHDM EGKELSKGQA
KKLKKLFEAQ EKLYKEYLQM AQNGSFQ
//