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Database: UniProt
Entry: A0A2I3STP4_PANTR
LinkDB: A0A2I3STP4_PANTR
Original site: A0A2I3STP4_PANTR 
ID   A0A2I3STP4_PANTR        Unreviewed;      2658 AA.
AC   A0A2I3STP4;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 4.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 3 {ECO:0000313|Ensembl:ENSPTRP00000080394};
GN   Name=ITPR3 {ECO:0000313|Ensembl:ENSPTRP00000080394,
GN   ECO:0000313|VGNC:VGNC:7896};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000080394, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000080394, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000080394}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
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DR   EMBL; AACZ04022819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPTRT00000077550; ENSPTRP00000080394; ENSPTRG00000018054.
DR   VGNC; VGNC:7896; ITPR3.
DR   GeneTree; ENSGT00940000157078; -.
DR   Proteomes; UP000002277; Chromosome 6.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2188   2213       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2225   2243       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2255   2275       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2311   2336       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2356   2378       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2485   2508       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      170    220       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      228    284       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      291    368       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      374    430       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       90    110       {ECO:0000256|SAM:Coils}.
FT   COILED     2616   2643       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2658 AA;  302898 MW;  6F5BD7F1AFBDEF46 CRC64;
     MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC
     PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS
     VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQSCPFL RRVVVGDKVI
     LNPVNAGQPL HASNYELSDN AGCKEVNSVN CNTSWKINLF MQFRDHLEEV LKGGDVVRLF
     HAEQEKFLTC DEYKGKLQVF LRTTLRQSAT SATSSNALWE VEVVHHDPCR GGAGHWNGLY
     RFKHLATGNY LAAEENPSYK GDTSDPKAAG MGAQGRAGRR NAGEKIKYRL VAVPHGNDIA
     SLFELDPTTL QKTDSFVPRN SYVRLRHLCT NTWIQSTNVP IDIEEERPIR LMLGTCPTKE
     DKEAFAIVSV PVSEIRDLDF ANDASFMLAS AVEKLNEGFI SQNDRRFVIQ LLEDLVFFVS
     DVPNNGQNVL DIMVSKPNRE RQKLMREQNI LKQIFGILKA PFREKGGEGP LVRLEELSDQ
     KNAPYQHMFR LCYRVLRHSQ EDYRKNQEHI AKQFGMMQSQ IGYDILAEDT ITALLHNNRK
     LLEKHITKTE VETFVSLVRK NREPRFLDYL SDLCVSNHIA IPVTQELICK CVLDPKNSDI
     LIRTELRPVK EMAQSHEYLS IEYSEEEVWL TWTDKNNEHH EKSVRQLAQE ARAGNAHDEN
     VLSYYRYQLK LFARMCLDRQ YLAIDEISQQ LGVDLIFLCM ADEMLPFDLR ASFCHLMLHV
     HVDRDPQELV TPVKFARLWT EIPTAITIKD YDSNLNASRD DKKNKFANTM EFVEDYLNNV
     VSEAVPFANE EKNKLTFEVV SLAHNLIYFG FYSFSELLRL TRTLLGIIDC AYEDPGGENV
     RRSIQGVGHM MSTMVLSRKQ SVFSAPSLSA GASAAEPLDR SKFEENEDIV VMETKLKILE
     ILQFILNVRL DYRISYLLSV FKKEFVEVFP MQDSGADGTA PAFDSTTANM NLDRIGEQAE
     AMFGVGKTSS MLEVDDEGGR MFLRVLIHLT MHDYAPLVSG ALQLLFKHFS QRQEAMHTFK
     QVQLLISAQD VENYKVIKSE LDRLRTMVEK SELWVDKKGS GKGEEVEAGA TKDKKERPTD
     EEGFLHPPGE KSSENYQIVK GILERLNKMC GVGEQMRKKQ QRLLKNMDAH KVMLDLLQIP
     YDKGDAKMME ILRYTHQFLQ KFCAGNPGNQ ALLHKHLHLF LTPGLLEAET MQHIFLNNYQ
     LCSEISEPVL QHFVHLLATH GRHVQYLDFL HTVIKAEGKY VKKCQDMIMT ELTNAGDDVV
     VFYNDKASLA HLLDMMKAAR DGVEDHSPLM YHISLVDLLA ACAEGKNVYT EIKCTSLLPL
     EDVVSVVTHE DCITEVKMAY VNFVNHCYVD TEVEMKEIYT SNHIWTLFEN FTLDMARVCS
     KREKRMADPT LEKYVLSVVL DTINAFFSSP FSENSTSLQT HQTIVVQLLQ STTRLLECPW
     LQQQHKGSVE ACIRTLAMVA KGRAILLPLD LDAHISSMLS SGASCAAAAQ RNASSYKATT
     RAFPRVTPTA NQWDYKNIIE KLQDIITALE ERLKPLVQAE LSVLVDVLHW PELLFLEGSE
     AYQRCESGGF LSKLIQHTKD LMESEEKLCI KVLRTLQQML LKKTKYGDRG NQLRKMLLQN
     YLQNRKSTSR GDLPDPIGTG LDPDWSAIAA TQCRLDKEGA TKLVCDLITS TKNEKIFQES
     IGLAIHLLDG GNTEIQKSFH NLMMSDKKSE RFFKVLHDRM KRAQQETKST VAVNMNDLGS
     QPHEDREPVD PTTKGRVASF SIPGSSSHYS LGPSLRRGHE VSERVQSSEM GTSVLIMQPI
     LRFLQLLCEN HNRDLQNFLR CQNNKTNYNL VCETLQFLDI MCGSTTGGLG LLGLYINEDN
     VGLVIQTLET LTEYCQGPCH ENQTCIVTHE SNGIDIITAL ILNDISPLCK YRMDLVLQLK
     DNASKLLLAL MESRHDSENA ERILISLRPQ ELVDVIKKAY LQEEERENSE VSPREVGHNI
     YILALQLSRH NKQLQHLLKP VKRIQEEEAE SISSMLSLNN KQLSQMLKSS VPAQEDEEDP
     LAYYENHTSQ IEIVRQDRSM EQIVFPVPGI CQFLTEETKH RLFTTTEQDE QGSKVSDFFD
     QSSFLHNEME WQRKLRSMPL IYWFSRRMTL WGSISFNLAV FINIIIAFFY PYMEGASTGV
     LDSPLISLLF WILICFSIAA LFTKRYSIRP LIVALILRSI YYLGIGPTLN ILGALNLTNK
     IVFVVSFVGN RGTFIRGYKA MVMDMEFLYH VGYILTSVLG LFAHELFYSI LLFDLIYREE
     TLFNVIKSVT RNGRSILLTA LLALILVYLF SIVGFLFLKD DFILEVDRLP NNHSTASPLG
     MPHGAAAFVD TCSGDKMDCV SGVSVPEVLE EDRELDSTER ACDTLLMCIV TVMNHGLRNG
     GGVGDILRKP SKDESLFPAR VVYDLLFFFI VIIIVLNLIF GVIIDTFADL RSEKQKKEEI
     LKTTCFICGL ERDKFDNKTV SFEEHIKLEH NMWNYLYFIV LVRVKNKTDY TGPESYVAQM
     IKNKNLDWFP RMRAMSLVSN EGEGEQNEIR ILQDKLNSTM KLVSHLTAQL NELKEQMTEQ
     RKRRQRLGFV DVQNCISR
//
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