ID A0A2I3SVN7_PANTR Unreviewed; 959 AA.
AC A0A2I3SVN7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Signal peptide, CUB domain and EGF like domain containing 2 {ECO:0000313|Ensembl:ENSPTRP00000081054.1};
GN Name=SCUBE2 {ECO:0000313|Ensembl:ENSPTRP00000081054.1,
GN ECO:0000313|VGNC:VGNC:7676};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000081054.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000081054.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000081054.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AACZ04016612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3SVN7; -.
DR Ensembl; ENSPTRT00000078679.1; ENSPTRP00000081054.1; ENSPTRG00000003342.6.
DR VGNC; VGNC:7676; SCUBE2.
DR GeneTree; ENSGT00940000153185; -.
DR Proteomes; UP000002277; Chromosome 11.
DR Bgee; ENSPTRG00000003342; Expressed in colon and 20 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF3; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR Pfam; PF14670; FXa_inhibition; 4.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..959
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014134004"
FT DOMAIN 42..82
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 361..399
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 400..440
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 769..881
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 365..375
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 959 AA; 105500 MW; 64E85D21FAD502B4 CRC64;
MGVAGRNRPG AAWAVLLLLL PPLLLAGAVP PGRGRAAGPQ EDVDECAQGL DDCHADALCQ
NTPTSYKCSC KPGYQGEGRQ CEDIDECGNE LNGGCVHDCL NIPGNYRCTC FDGFMLAHDG
HNCLDVDECL ENNGGCQHTC VNVMGSYECC CKEGFFLSDN QHTCIHRSEE SLSCMNKDHG
CSHICKEAPR GSVACECRPG FELAKNQRDC ILTCNHGNGG CQHSCDDTAD GPECSCHPQY
KMHTDGRSCL EREDTVLEVT ESNTTSVVDG DKRVKRRLLM ETCAVNNGGC DRTCKDTSTG
VHCSCPVGFT LQLDGKTCKD IDECQTRNGG CDHFCKNTVG SFDCSCKKGF KLLTDEKSCQ
DVDECSLDRT CDHSCINHPG TFACACNRGY TLYGFTHCGD TNECSINNGG CQQVCVNTVG
SYECQCHPGY KLHWNKKDCV EVKGLLPTSV SPRVSLHCGK SGGGDRCFLR CHSGIHLSSG
LQGAYSVTCG SSSPLRNKQQ KSNDSAFGDV TTIRTSVTFK LNEGKCSLKN AELFPEGLRP
ALPEKHSSVK ESFRYVNLTC SSGKQVPGAP GRPSTPKEMF ITVEFELETN QKEVTASCDL
SCIVKRTEKR LRKAIRTLRK AVHREQFHLQ LSGMNLDVAK KPPRTSERQA ESCGVGQGHA
ENQCGLCQPG EYSADGFAPC QLCALGTFQP EAGRTSCFPC GGGLATKHQG ATSFQDCETR
GEYLLMVWLP PGTHSQMVSF SCPIPGWQQG CCGAQQAIGG QDRDDNRRCG GELGDFTGYI
ESPNYPGNYP ANTECTWTIN PPPKRRILIV VPEIFLPIED DCGDYLVMRK TSSSNSVTTY
ETCQTYERPI AFTSRSKKLW IQFKSNEGNS ARGFQVPYVT YDEDYQELIE DIVRDGRLYA
SENHQEILKD KKLIKALFDV LAHPQNYFKY TAQESREMFP RSFIRLLRSK VSRFLRPYK
//
