ID A0A2I3SW02_PANTR Unreviewed; 1187 AA.
AC A0A2I3SW02;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=IQ motif and Sec7 domain ArfGEF 3 {ECO:0000313|Ensembl:ENSPTRP00000081156.1};
GN Name=IQSEC3 {ECO:0000313|Ensembl:ENSPTRP00000081156.1,
GN ECO:0000313|VGNC:VGNC:13154};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000081156.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000081156.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000081156.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BRAG family.
CC {ECO:0000256|ARBA:ARBA00006248}.
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DR EMBL; AACZ04028104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04028105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04028106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04028107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04028108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016778158.1; XM_016922669.1.
DR AlphaFoldDB; A0A2I3SW02; -.
DR PaxDb; 9598-ENSPTRP00000025257; -.
DR Ensembl; ENSPTRT00000097741.1; ENSPTRP00000081156.1; ENSPTRG00000004503.5.
DR GeneID; 749108; -.
DR KEGG; ptr:749108; -.
DR CTD; 440073; -.
DR VGNC; VGNC:13154; IQSEC3.
DR GeneTree; ENSGT00940000155908; -.
DR InParanoid; A0A2I3SW02; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000002277; Chromosome 12.
DR Bgee; ENSPTRG00000004503; Expressed in dorsolateral prefrontal cortex and 13 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd14686; bZIP; 1.
DR CDD; cd13318; PH_IQSEC; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF318; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 649..842
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 62..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1095
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1126..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 22..56
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 64..78
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..588
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1026
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1042
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1044..1059
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1094
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1166
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1187 AA; 128196 MW; 38A4ED7528A8DCFF CRC64;
MESLLENPVR AVLYLKELTA IVQNQQSLIH TQRERIDELE RRLDELSAEN RSLWEHQQLL
QAQPPPGLVP PSSAPLPAAP ATAPAAAARA QEPLQDQGQR SAAAPHPAPD QPPLQHHGQL
LEQPQRGPGS RAHTPQSPHK HLGTQGAVTD KEKERPPSCC AAAGALLQHK SPSALGKGVL
SRRPENETVL HQFCCPAADA EQKPACSDLA SQSDGSCTQA GGGMEDSVVA AAAVAAGRPS
AHAPKAQAQE LQEEEERPGA GAASPRAGPQ HKASPGRQQP ALATALCSHA PAASDYELSL
DLKNKQIEML EHKYGGHLVS RRAACTIQTA FRQYQLSKNF EKIRNSLLES RLPRRISLRK
VRSPTAESLA AEKALMEGYG LLGLPLVRSP SLPPTFAGTL TELEDSFTEQ VQSLAKSIDD
ALSTWSLKTM CSLQESGAYQ LHQALQAAAG PPGLEAEGRE PESAGPGPGD DAAETPGLPP
AHSGTLMMAF RDVTVQIANQ NISVSSSTAL SVANCLGAQT VQAPAEPAAG KAEQGETSGR
EAPEAPAVGR EDASAEDSCA AAGASGAADE ATAPKTEEEE EEEETAEVGR GAEAEAGDVE
QLSSSSTSTK SAKSGSEASA SASKDALQAM ILSLPRYHCE NPASCKSPTL STDTLRKRLY
RIGLNLFNIN PDKGIQFLIS RGFIPDTPIG VAHFLLQRKG LSRQMIGEFL GNSKKQFNRD
VLDCVVDEMD FSSMELDEAL RKFQAHIRVQ GEAQKVERLI EAFSQRYCMC NPEVVQQFHN
PDTIFILAFA IILLNTDMYS PNIKPDRKMM LEDFIRNLRG VDDGADIPRE LVVGIYERIQ
QKELKSNEDH VTYVTKVEKS IVGMKTVLSV PHRRLVCCSR LFEVTDVNKL QKQAAHQREV
FLFNDLLVIL KLCPKKKGSS TYTFCKSVGL LGMQFQLFEN EYYSHGITLV TPLSGSEKKQ
VLHFCALGSD EMQKFVEDLK ESIAEVTELE QIRIEWELEK QQGTKTLSFK PCGAQGDPQS
KQGSPTAKRE AALRERPAES TVEVSIHNRL QTSQHNSGPG AERGAPVPPP DLQPSPPRQQ
TPPLPPPPPT PPGTLVQCQQ IVKVIVLDKP CLARMEPLLS QALSCYTSSS SDSCGSTPLR
GPGSPVKVTH QPPLPPPPPP YNHPHQFCPP GSLLHGRRYS SGSRSLV
//