ID A0A2I3SX84_PANTR Unreviewed; 911 AA.
AC A0A2I3SX84;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN Name=UNC5C {ECO:0000313|Ensembl:ENSPTRP00000081598.1,
GN ECO:0000313|VGNC:VGNC:2063};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000081598.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000081598.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000081598.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR EMBL; AACZ04021276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04021277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04021278; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04021279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3SX84; -.
DR Ensembl; ENSPTRT00000088236.1; ENSPTRP00000081598.1; ENSPTRG00000016296.5.
DR VGNC; VGNC:2063; UNC5C.
DR GeneTree; ENSGT00950000182815; -.
DR Proteomes; UP000002277; Chromosome 4.
DR Bgee; ENSPTRG00000016296; Expressed in spleen and 16 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR CDD; cd08799; Death_UNC5C; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR042154; Death_UNC5C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF7; NETRIN RECEPTOR UNC5C; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT TRANSMEM 357..382
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 155..236
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 510..653
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
SQ SEQUENCE 911 AA; 101386 MW; 859BD88FEA239655 CRC64;
AELIYGLLQC VNHFPLSSCF SDDDFFHELP ETFPSDPPEP LPHFLIEPEE AYIVKNKPVN
LYCKASPATQ IYFKCNSEWV HQKDHIVDER VDETSGLIVR EVSIEISRQQ VEELFGPEDY
WCQCVAWSSA GTTKSRKAYV RIAYLRKTFE QEPLGKEVSL EQEVLLQCRP PEGIPVAEVE
WLKNEDIIDP VEDRNFYITI DHNLIIKQAR LSDTANYTCV AKNIVAKRKS TTATVIVYVN
GGWSTWTEWS VCNSRCGRGY QKRTRTCTNP APLNGGAFCE GQSVQKIACT TLCPVDGRWT
PWSKWSTCGT ECTHWRRREC TAPAPKNGGK DCDGLVLQSK NCTDGLCMQT APDSDDVALY
VGIVIAVIVC LAISVVVALF VYRKNHRDFE SDIIDSSALN GGFQPVNIKA ARQDLLAVPP
DLTSAAAMYR GPVYALHDVS DKIPMTNSPI LDPLPNLKIK VYNTSGAVTP QDDLSEFTSK
LSPQMTQSLL ENEALSLKNQ SLARQTDPSC TAFGSFNSLG GHLIVPNSGV SLLIPAGAIP
QGRVYEMYVT VHRKETMRPP MDDSQTLLTP VVSCGPPGAL LTRPVVLTMH HCADPNTEDW
KILLKNQAAQ GQWEDVVVVG EENFTTPCYI QLDAEACHIL TENLSTYALV GHSTTKAAAK
RLKLAIFGPL CCSSLEYSIR VYCLDDTQDA LKEILHLERQ MGGQLLEEPK ALHFKGSTHN
LRLSIHDIAH SLWKSKLLAK YQEIPFYHVW SGSQRNLHCT FTLERFSLNT VELVCKLCVR
QVEGEGQIFQ LNCTVSEEPT GIDLPLLDPA NTITTVTGPS AFSIPLPIRQ KLCSSLDAPQ
TRGHDWRMLA HKLNLDRYLN YFATKSSPTG VILDLWEAQN FPDGNLSMLA AVLEEMGRHE
TVVSLAAEGQ Y
//
