ID A0A2I3SYJ4_PANTR Unreviewed; 4933 AA.
AC A0A2I3SYJ4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSPTRP00000082050.1};
GN Name=RYR2 {ECO:0000313|Ensembl:ENSPTRP00000082050.1,
GN ECO:0000313|VGNC:VGNC:6990};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000082050.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000082050.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000082050.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671,
CC ChEBI:CHEBI:29108; Evidence={ECO:0000256|ARBA:ARBA00036634};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
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DR EMBL; AACZ04026659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04026660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04026661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPTRT00000095134.1; ENSPTRP00000082050.1; ENSPTRG00000002149.7.
DR VGNC; VGNC:6990; RYR2.
DR GeneTree; ENSGT00940000154906; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000002149; Expressed in heart and 15 other cell types or tissues.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 3.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF7; RYANODINE RECEPTOR 2; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 4.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50188; B302_SPRY; 3.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50919; MIR; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 4253..4272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4466..4486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4540..4559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4676..4697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4734..4755
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4810..4833
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 111..166
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 226..281
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 287..344
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 352..409
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 600..810
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1026..1223
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1338..1563
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 3996..4031
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1857..1892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2355..2380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4933 AA; 560225 MW; 1F7FA9AF83258321 CRC64;
MIWTVQSCHV SLIFPSLSPP LQDDEVVLQC TATIHKEQQK LCLAAEGFGN RLCFLESTSN
SKNVPPDLSI CTFVLEQSLS VRALQEMLAN TVEKSEGQVD VEKWTAQGGG HRTLLYGHAI
LLRHSYSGMY LCCLSTSRSS TDKLAFDVGL QEDTTGEACW WTIHPASKQR SEGEKVRVGD
DLILVSVSSE RYLHLSYGNG SLHVDAAFQQ TLWSVAPISS GSEAAQGYLI GGDVLRLLHG
HMDECLTVPS GEHGEEQRRT VHYEGGAVSV HARSLWRLET LRVAWSGSHI RWGQPFRLRH
VTTGKYLSLM EDKNLLLMDK EKADVKSTAF TFRSSKEKLD VGVRKEVDGM GTSEIKYGDS
VCYIQHVDTG LWLTYQSVDV KSVRMGSIQR KAIMHHEGHM DDGISLSRSQ HEESRTARVI
RSTVFLFNRF IRGLDALSKK AKASTVDLPI ESVSLSLQDL IGYFHPPDEH LEHEDKQNRL
RALKNRQNLF QEEGMINLVL ECIDRLHVYS SAAHFADVAG REAGESWKSI LNSLYELLAA
LIRGNRKNCA QFSGSLDWLI SRLERLEASS GILEVLHCVL VESPEALNII KEGHIKSIIS
LLDKHGRNHK VLDVLCSLCV CHGVAVRSNQ HLICDNLLPG RDLLLQTRLV NHVSSMRPNI
FLGVSEGSAQ YKKWYYELMV DHTEPFVTAE ATHLRVGWAS TEGYSPYPGG GEEWGGNGVG
DDLFSYGFDG LHLWSGCIAR TVSSPNQHLL RTDDVISCCL DLSAPSISFR INGQPVQGMF
ENFNIDGLFF PVVSFSAGIK VRFLLGGRHG EFKFLPPPGY APCYEAVLPK EKLKVEHSRE
YKQERTYTRD LLGPTVSLTQ AAFTPIPVDT SQIVLPPHLE RIREKLAENI HELWVMNKIE
LGWQYGPVRD DNKRQHPCLV EFCKLPEQER NYNLQMSLET LKTLLALGCH VGISDEHAED
KVKKMKLPKN YQLTSGYKPA PMDLSFIKLT PSQEAMVDKL AENAHNVWAR DRIRQGWTYG
IQQDVKNRRN PRLVPYTLLD DRTKKSNKDS LREAVRTLLG YGYNLEAPDQ DHAARAEVCS
GTGERFRIFR AEKTYAVKAG RWYFEFETVT AGDMRVGWSR PGCQPDQELG SDERAFAFDG
FKAQRWHQGN EHYGRSWQAG DVVGCMVDMN EHTMMFTLNG EILLDDSGSE LAFKDFDVGD
GFIPVCSLGV AQVGRMNFGK DVSTLKYFTI CGLQEGYEPF AVNTNRDITM WLSKRLPQFL
QVPSNHEHIE VTRIDGTIDS SPCLKVTQKS FGSQNSNTDI MFYRLSMPIE CAEVFSKTVA
GGLPGAGLFG PKNDLEDYDA DSDFEVLMKT AHGHLVPDRV DKDKEATKPE FNNHKDYAQE
KPSRLKQRFL LRRTKPDYST SHSARLTEDV LADDRDDYDF LMQTSTYYYS VRIFPGQEPA
NVWVGWITSD FHQYDTGFDL DRVRTVTVTL GDEKGKVHES IKRSNCYMVC AGESMSPGQG
RNNNGLEIGC VVDAASGLLT FIANGKELST YYQVEPSTKL FPAVFAQATS PNVFQFELGR
IKNVMPLSAG LFKSEHKNPV PQCPPRLHVQ FLSHVLWSRM PNQFLKVDVS RISERQGWLV
QCLDPLQFMS LHIPEENRSV DILELTEQEE LLKFHYHTLR LYSAVCALGN HRVAHALCSH
VDEPQLLYAI ENKYMPGLLR AGYYDLLIDI HLSSYATARL MMNNEYIVPM TEETKSITLF
PDENKKHGLP GIGLSTSLRP RMQFSSPSFV SISNECYQYS PEFPLDILKS KTIQMLTEAV
KEGSLHARDP VGGTTEFLFV PLIKLFYTLL IMGIFHNEDL KHILQLIEPS VFKEAATPEE
ESDTLEKELS VDDAKLQGAG EEEAKGGKRP KEGLLQMKLP EPVKLQMCLL LQYLCDCQVR
HRIEAIVAFS DDFVAKLQDN QRFRYNEVMQ ALNMSAALTA RKTKEFRSPP QEQINMLLNF
KDDKSECPCP EEIRDQLLDF HEDLMTHCGI ELDEDGSLDG NSDLTIRGRL LSLVEKVTYL
KKKQAEKPVE SDSKKSSTLQ QLISETMVRW AQESVIEDPE LVRAMFVLLH RQYDGIGGLV
RALPKTYTIN GVSVEDTINL LASLGQIRSL LSVRMGKEEE KLMIRGLGDI MNNKVFYQHP
NLMRALGMHE TVMEVMVNVL GGGESKEITF PKMVANCCRF LCYFCRISRQ NQKAMFDHLS
YLLENSSVGL ASPAMRGSTP LDVAAASVMD NNELALALRE PDLEKVVRYL AGCGLQSCQM
LVSKGYPDIG WNPVEGERYL DFLRFAVFCN GESVEENANV VVRLLIRRPE CFGPALRGEG
GNGLLAAMEE AIKIAEDPSR DGPSPNSGSS KTLDTEEEED DTIHMGNAIM TFYSALIDLL
GRCAPEMHLI HAGKGEAIRI RSILRSLIPL GDLVGVISIA FQMPTIAKDG NVVEPDMSAG
FCPDHKAAMV LFLDRVYGIE VQDFLLHLLE VGFLPDLRAA ASLDTAALSA TDMALALNRY
LCTAVLPLLT RCAPLFAGTE HHASLIDSLL HTVYRLSKGC SLTKAQRDSI EVCLLSICGQ
LRPSMMQHLL RRLVFDVPLL NEHAKMPLKL LTNHYERCWK YYCLPGGWGN FGAASEEELH
LSRKLFWGIF DALSQKKYEQ ELFKLALPCL SAVAGALPPD YMESNYVSMM EKQSSMDSEG
NFNPQPVDTS NITIPEKLEY FINKYAEHSH DKWSMDKLAN GWIYGEIYSD SSKVQPLMKP
YKLLSEKEKE IYRWPIKESL KTMLAWGWRI ERTREGDSMA LYNRTRRISQ TSQVSVDAAH
GYSPRAIDMS NVTLSRDLHA MAEMMAENYH NIWAKKKKME LESKGGGNHP LLVPYDTLTA
KEKAKDREKA QDILKFLQIN GYAVSRGFKD LELDTPSIEK RFAYSFLQQL IRYVDEAHQY
ILEFDGGSRG KGEHFPYEQE IKFFAKVVLP LIDQYFKNHR LYFLSAASRP LCSGGHASNK
EKEMNIEKFS GQFIQHFVSS LGNDATSIVN CLHILGQTLD ARTVMKTGLE SVKSALRAFL
DNAAEDLEKT MENLKQGQFT HTRNQPKGVT QIINYTTVAL LPMLSSLFEH IGQHQFGEDL
ILEDVQVSCY RILTSLYALG TSKSIYVERQ RSALGECLAA FAGAFPIAFL ETHLDKHNIY
SIYNTKSSRE RAALSLPTNV EDVCPNIPSL EKLMEEIVEL AESGIRYTQM PHVMEVILPM
LCSYMSRWWE HGPENNPERA EMCCTALNSE HMNTLLGNIL KIIYNNLGID EGAWMKRLAV
FSQPIINKVK PQLLKTHFLP LMEKLKKKAA TVVSEEDHLK AEARGDMSEA ELLILDEFTT
LKYLYPFLII LIYQINTYLC KNLQVLLVLT EISFATSQNF KREEQNFVVQ NEINNMSFLI
TDTKSKMSKA AVSDQERKKM KRKGDRYSMQ TSLIVAALKR LLPIGLNICA PGDQELIALA
KNRFSLKDTE DEVRDIIRSN IHLQGKLEDP AIRWQMALYK DLPNRTDDTS DPEKTVERVL
DIANVLFHLE QKSKRVGRRH YCLGSTVEHP QRSKKAVWHK LLSKQRKRAV VACFRMAPLY
NLPRHRAVNL FLQGYEKSWI ETEEHYFEDK LIEDLAKPGA EPPEEDEGTK RVDPLHQLIL
LFSRTALTEK CCHDEEDDDG EEEVKSFEEK EMEKQKLLYQ QARLHDRGAA EMVLQTISAS
KGETGPMVAA TLKLGIAILN GGNSTVQQKM LDYLKEKKDV GFFQSLAGLM QSCSVLDLNA
FERQNKAEGL GMVTEEGSGE KVLQDDEFTC DLFRFLQLLC EGHNSDFQNY LRTQTGNNTT
VNIIISTVDY LLRVQESISD FYWYYSGKDV IDEQGQRNFS KAIQVAKQVF NTLTEYIQGP
CTGNQQSLAH SRLWDAVVGF LHVFAHMQMK LSQDSSQIEL LKELMDLQKD MVVMLLSMLE
GNVVNGTIGK QMVDMLVESS NNVEMILKFF DMFLKLKDLT SSDTFKEYDP DGKGVISKRD
FHKAMESHKH YTQSETEFLL SCAETDENET LDYEEFVKRF HEPAKDIGFN VAVLLTNLSE
HMPNDTRLQT FLELAESVLN YFQPFLGRIE IMGSAKRIER VYFEISESSR TQWEKPQVKE
SKRQFIFDVV NEGGEKEKME LFVNFCEDTI FEMQLAAQIS ESDLNGRSAN KEESEKERPE
EQGPRMAFFS ILTVKSALFA LRYNILTLMR MLSLKSLKKQ MKKVKKMTVK DMVTAFFSSY
WSIFMTLLHF VASVFRGFSR IICSLLLGGS LVEGAKKIKV AELLANMPDP TQDEVRGDGE
EGERKPLEAA LPSEDLTDLK ELTEESDLLS DIFGLDLKRE GGQYKLIPHN PNAGLSDLMS
NPVPMPEVQE KFQFFSFWRA YVLFVCFHRG EDGEKEEKAK EDKGKQKLRQ LHTHRYGEPE
VPESAFWKKI IAYQQKLLNY FARNFYNMRM LALFVAFAIN FILLFYKVST SSVVEGKELP
TRSSSENAKV TSLDSSSHRI IAVHYVLEES SGYMEPTLRI LAILHTVISF FCIIGYYCLK
VPLVIFKREK EVARKLEFDG LYITEQPSED DIKGQWDRLV INTQSFPNNY WDKFVKRKVM
DKYGEFYGRD RISELLGMDK AALDFSDARE KKKPKKDSSL SAVLNSIDVK YQMWKLGVVF
TDNSFLYLAW YMTMSVLGHY NNFFFAAHLL DIAMGFKTLR TILSSVTHNG KQLVLTVGLL
AVVVYLYTVV AFNFFRKFYN KSEDGDTPDM KCDDMLTCYM FHMYVGVRAG GGIGDEIEDP
AGDEYEIYRI IFDITFFFFV IVILLAIIQG LIIDAFGELR DQQEQVKEDM ETKCFICGIG
NDYFDTVPHG FETHTLQEHN LANYLFFLMY LINKDETEHT GQESYVWKMY QERCWEFFPA
GDCFRKQYED QLN
//
