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Database: UniProt
Entry: A0A2I3SYJ4_PANTR
LinkDB: A0A2I3SYJ4_PANTR
Original site: A0A2I3SYJ4_PANTR 
ID   A0A2I3SYJ4_PANTR        Unreviewed;      4933 AA.
AC   A0A2I3SYJ4;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 5.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSPTRP00000082050};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSPTRP00000082050,
GN   ECO:0000313|VGNC:VGNC:6990};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000082050, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000082050, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000082050}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AACZ04026659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04026660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04026661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPTRT00000095134; ENSPTRP00000082050; ENSPTRG00000002149.
DR   VGNC; VGNC:6990; RYR2.
DR   GeneTree; ENSGT00940000154906; -.
DR   Proteomes; UP000002277; Chromosome 1.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4253   4272       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4466   4486       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4540   4559       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4676   4697       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4734   4755       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4810   4833       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      111    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    218       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      226    281       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      287    344       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      352    409       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      600    810       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1026   1223       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1338   1563       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3996   4031       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      473    493       {ECO:0000256|SAM:Coils}.
FT   COILED     3057   3077       {ECO:0000256|SAM:Coils}.
FT   COILED     3322   3342       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4933 AA;  560225 MW;  1F7FA9AF83258321 CRC64;
     MIWTVQSCHV SLIFPSLSPP LQDDEVVLQC TATIHKEQQK LCLAAEGFGN RLCFLESTSN
     SKNVPPDLSI CTFVLEQSLS VRALQEMLAN TVEKSEGQVD VEKWTAQGGG HRTLLYGHAI
     LLRHSYSGMY LCCLSTSRSS TDKLAFDVGL QEDTTGEACW WTIHPASKQR SEGEKVRVGD
     DLILVSVSSE RYLHLSYGNG SLHVDAAFQQ TLWSVAPISS GSEAAQGYLI GGDVLRLLHG
     HMDECLTVPS GEHGEEQRRT VHYEGGAVSV HARSLWRLET LRVAWSGSHI RWGQPFRLRH
     VTTGKYLSLM EDKNLLLMDK EKADVKSTAF TFRSSKEKLD VGVRKEVDGM GTSEIKYGDS
     VCYIQHVDTG LWLTYQSVDV KSVRMGSIQR KAIMHHEGHM DDGISLSRSQ HEESRTARVI
     RSTVFLFNRF IRGLDALSKK AKASTVDLPI ESVSLSLQDL IGYFHPPDEH LEHEDKQNRL
     RALKNRQNLF QEEGMINLVL ECIDRLHVYS SAAHFADVAG REAGESWKSI LNSLYELLAA
     LIRGNRKNCA QFSGSLDWLI SRLERLEASS GILEVLHCVL VESPEALNII KEGHIKSIIS
     LLDKHGRNHK VLDVLCSLCV CHGVAVRSNQ HLICDNLLPG RDLLLQTRLV NHVSSMRPNI
     FLGVSEGSAQ YKKWYYELMV DHTEPFVTAE ATHLRVGWAS TEGYSPYPGG GEEWGGNGVG
     DDLFSYGFDG LHLWSGCIAR TVSSPNQHLL RTDDVISCCL DLSAPSISFR INGQPVQGMF
     ENFNIDGLFF PVVSFSAGIK VRFLLGGRHG EFKFLPPPGY APCYEAVLPK EKLKVEHSRE
     YKQERTYTRD LLGPTVSLTQ AAFTPIPVDT SQIVLPPHLE RIREKLAENI HELWVMNKIE
     LGWQYGPVRD DNKRQHPCLV EFCKLPEQER NYNLQMSLET LKTLLALGCH VGISDEHAED
     KVKKMKLPKN YQLTSGYKPA PMDLSFIKLT PSQEAMVDKL AENAHNVWAR DRIRQGWTYG
     IQQDVKNRRN PRLVPYTLLD DRTKKSNKDS LREAVRTLLG YGYNLEAPDQ DHAARAEVCS
     GTGERFRIFR AEKTYAVKAG RWYFEFETVT AGDMRVGWSR PGCQPDQELG SDERAFAFDG
     FKAQRWHQGN EHYGRSWQAG DVVGCMVDMN EHTMMFTLNG EILLDDSGSE LAFKDFDVGD
     GFIPVCSLGV AQVGRMNFGK DVSTLKYFTI CGLQEGYEPF AVNTNRDITM WLSKRLPQFL
     QVPSNHEHIE VTRIDGTIDS SPCLKVTQKS FGSQNSNTDI MFYRLSMPIE CAEVFSKTVA
     GGLPGAGLFG PKNDLEDYDA DSDFEVLMKT AHGHLVPDRV DKDKEATKPE FNNHKDYAQE
     KPSRLKQRFL LRRTKPDYST SHSARLTEDV LADDRDDYDF LMQTSTYYYS VRIFPGQEPA
     NVWVGWITSD FHQYDTGFDL DRVRTVTVTL GDEKGKVHES IKRSNCYMVC AGESMSPGQG
     RNNNGLEIGC VVDAASGLLT FIANGKELST YYQVEPSTKL FPAVFAQATS PNVFQFELGR
     IKNVMPLSAG LFKSEHKNPV PQCPPRLHVQ FLSHVLWSRM PNQFLKVDVS RISERQGWLV
     QCLDPLQFMS LHIPEENRSV DILELTEQEE LLKFHYHTLR LYSAVCALGN HRVAHALCSH
     VDEPQLLYAI ENKYMPGLLR AGYYDLLIDI HLSSYATARL MMNNEYIVPM TEETKSITLF
     PDENKKHGLP GIGLSTSLRP RMQFSSPSFV SISNECYQYS PEFPLDILKS KTIQMLTEAV
     KEGSLHARDP VGGTTEFLFV PLIKLFYTLL IMGIFHNEDL KHILQLIEPS VFKEAATPEE
     ESDTLEKELS VDDAKLQGAG EEEAKGGKRP KEGLLQMKLP EPVKLQMCLL LQYLCDCQVR
     HRIEAIVAFS DDFVAKLQDN QRFRYNEVMQ ALNMSAALTA RKTKEFRSPP QEQINMLLNF
     KDDKSECPCP EEIRDQLLDF HEDLMTHCGI ELDEDGSLDG NSDLTIRGRL LSLVEKVTYL
     KKKQAEKPVE SDSKKSSTLQ QLISETMVRW AQESVIEDPE LVRAMFVLLH RQYDGIGGLV
     RALPKTYTIN GVSVEDTINL LASLGQIRSL LSVRMGKEEE KLMIRGLGDI MNNKVFYQHP
     NLMRALGMHE TVMEVMVNVL GGGESKEITF PKMVANCCRF LCYFCRISRQ NQKAMFDHLS
     YLLENSSVGL ASPAMRGSTP LDVAAASVMD NNELALALRE PDLEKVVRYL AGCGLQSCQM
     LVSKGYPDIG WNPVEGERYL DFLRFAVFCN GESVEENANV VVRLLIRRPE CFGPALRGEG
     GNGLLAAMEE AIKIAEDPSR DGPSPNSGSS KTLDTEEEED DTIHMGNAIM TFYSALIDLL
     GRCAPEMHLI HAGKGEAIRI RSILRSLIPL GDLVGVISIA FQMPTIAKDG NVVEPDMSAG
     FCPDHKAAMV LFLDRVYGIE VQDFLLHLLE VGFLPDLRAA ASLDTAALSA TDMALALNRY
     LCTAVLPLLT RCAPLFAGTE HHASLIDSLL HTVYRLSKGC SLTKAQRDSI EVCLLSICGQ
     LRPSMMQHLL RRLVFDVPLL NEHAKMPLKL LTNHYERCWK YYCLPGGWGN FGAASEEELH
     LSRKLFWGIF DALSQKKYEQ ELFKLALPCL SAVAGALPPD YMESNYVSMM EKQSSMDSEG
     NFNPQPVDTS NITIPEKLEY FINKYAEHSH DKWSMDKLAN GWIYGEIYSD SSKVQPLMKP
     YKLLSEKEKE IYRWPIKESL KTMLAWGWRI ERTREGDSMA LYNRTRRISQ TSQVSVDAAH
     GYSPRAIDMS NVTLSRDLHA MAEMMAENYH NIWAKKKKME LESKGGGNHP LLVPYDTLTA
     KEKAKDREKA QDILKFLQIN GYAVSRGFKD LELDTPSIEK RFAYSFLQQL IRYVDEAHQY
     ILEFDGGSRG KGEHFPYEQE IKFFAKVVLP LIDQYFKNHR LYFLSAASRP LCSGGHASNK
     EKEMNIEKFS GQFIQHFVSS LGNDATSIVN CLHILGQTLD ARTVMKTGLE SVKSALRAFL
     DNAAEDLEKT MENLKQGQFT HTRNQPKGVT QIINYTTVAL LPMLSSLFEH IGQHQFGEDL
     ILEDVQVSCY RILTSLYALG TSKSIYVERQ RSALGECLAA FAGAFPIAFL ETHLDKHNIY
     SIYNTKSSRE RAALSLPTNV EDVCPNIPSL EKLMEEIVEL AESGIRYTQM PHVMEVILPM
     LCSYMSRWWE HGPENNPERA EMCCTALNSE HMNTLLGNIL KIIYNNLGID EGAWMKRLAV
     FSQPIINKVK PQLLKTHFLP LMEKLKKKAA TVVSEEDHLK AEARGDMSEA ELLILDEFTT
     LKYLYPFLII LIYQINTYLC KNLQVLLVLT EISFATSQNF KREEQNFVVQ NEINNMSFLI
     TDTKSKMSKA AVSDQERKKM KRKGDRYSMQ TSLIVAALKR LLPIGLNICA PGDQELIALA
     KNRFSLKDTE DEVRDIIRSN IHLQGKLEDP AIRWQMALYK DLPNRTDDTS DPEKTVERVL
     DIANVLFHLE QKSKRVGRRH YCLGSTVEHP QRSKKAVWHK LLSKQRKRAV VACFRMAPLY
     NLPRHRAVNL FLQGYEKSWI ETEEHYFEDK LIEDLAKPGA EPPEEDEGTK RVDPLHQLIL
     LFSRTALTEK CCHDEEDDDG EEEVKSFEEK EMEKQKLLYQ QARLHDRGAA EMVLQTISAS
     KGETGPMVAA TLKLGIAILN GGNSTVQQKM LDYLKEKKDV GFFQSLAGLM QSCSVLDLNA
     FERQNKAEGL GMVTEEGSGE KVLQDDEFTC DLFRFLQLLC EGHNSDFQNY LRTQTGNNTT
     VNIIISTVDY LLRVQESISD FYWYYSGKDV IDEQGQRNFS KAIQVAKQVF NTLTEYIQGP
     CTGNQQSLAH SRLWDAVVGF LHVFAHMQMK LSQDSSQIEL LKELMDLQKD MVVMLLSMLE
     GNVVNGTIGK QMVDMLVESS NNVEMILKFF DMFLKLKDLT SSDTFKEYDP DGKGVISKRD
     FHKAMESHKH YTQSETEFLL SCAETDENET LDYEEFVKRF HEPAKDIGFN VAVLLTNLSE
     HMPNDTRLQT FLELAESVLN YFQPFLGRIE IMGSAKRIER VYFEISESSR TQWEKPQVKE
     SKRQFIFDVV NEGGEKEKME LFVNFCEDTI FEMQLAAQIS ESDLNGRSAN KEESEKERPE
     EQGPRMAFFS ILTVKSALFA LRYNILTLMR MLSLKSLKKQ MKKVKKMTVK DMVTAFFSSY
     WSIFMTLLHF VASVFRGFSR IICSLLLGGS LVEGAKKIKV AELLANMPDP TQDEVRGDGE
     EGERKPLEAA LPSEDLTDLK ELTEESDLLS DIFGLDLKRE GGQYKLIPHN PNAGLSDLMS
     NPVPMPEVQE KFQFFSFWRA YVLFVCFHRG EDGEKEEKAK EDKGKQKLRQ LHTHRYGEPE
     VPESAFWKKI IAYQQKLLNY FARNFYNMRM LALFVAFAIN FILLFYKVST SSVVEGKELP
     TRSSSENAKV TSLDSSSHRI IAVHYVLEES SGYMEPTLRI LAILHTVISF FCIIGYYCLK
     VPLVIFKREK EVARKLEFDG LYITEQPSED DIKGQWDRLV INTQSFPNNY WDKFVKRKVM
     DKYGEFYGRD RISELLGMDK AALDFSDARE KKKPKKDSSL SAVLNSIDVK YQMWKLGVVF
     TDNSFLYLAW YMTMSVLGHY NNFFFAAHLL DIAMGFKTLR TILSSVTHNG KQLVLTVGLL
     AVVVYLYTVV AFNFFRKFYN KSEDGDTPDM KCDDMLTCYM FHMYVGVRAG GGIGDEIEDP
     AGDEYEIYRI IFDITFFFFV IVILLAIIQG LIIDAFGELR DQQEQVKEDM ETKCFICGIG
     NDYFDTVPHG FETHTLQEHN LANYLFFLMY LINKDETEHT GQESYVWKMY QERCWEFFPA
     GDCFRKQYED QLN
//
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