ID A0A2I3T0C5_PANTR Unreviewed; 324 AA.
AC A0A2I3T0C5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Nucleoredoxin {ECO:0000256|ARBA:ARBA00026178};
DE EC=1.8.1.8 {ECO:0000256|ARBA:ARBA00012612};
GN Name=NXN {ECO:0000313|Ensembl:ENSPTRP00000082642.1,
GN ECO:0000313|VGNC:VGNC:12578};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000082642.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000082642.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000082642.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) +
CC NADH; Xref=Rhea:RHEA:18749, Rhea:RHEA-COMP:10593, Rhea:RHEA-
CC COMP:10594, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.8.1.8;
CC Evidence={ECO:0000256|ARBA:ARBA00000696};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) +
CC NADPH; Xref=Rhea:RHEA:18753, Rhea:RHEA-COMP:10593, Rhea:RHEA-
CC COMP:10594, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.8;
CC Evidence={ECO:0000256|ARBA:ARBA00001346};
CC -!- SIMILARITY: Belongs to the nucleoredoxin family.
CC {ECO:0000256|ARBA:ARBA00025782}.
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DR EMBL; AACZ04062745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04062746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04062747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04062748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04062749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04062750; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04062751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04062752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3T0C5; -.
DR Ensembl; ENSPTRT00000095023.1; ENSPTRP00000082642.1; ENSPTRG00000008513.6.
DR VGNC; VGNC:12578; NXN.
DR GeneTree; ENSGT00940000161894; -.
DR Proteomes; UP000002277; Chromosome 17.
DR Bgee; ENSPTRG00000008513; Expressed in colon and 20 other cell types or tissues.
DR GO; GO:0004791; F:thioredoxin-disulfide reductase (NADP) activity; IEA:InterPro.
DR CDD; cd03071; PDI_b'_NRX; 1.
DR CDD; cd03009; TryX_like_TryX_NRX; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 3.
DR InterPro; IPR041861; NRX_PDI_b.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR InterPro; IPR045870; TryX_NRX_thioredoxin_dom.
DR PANTHER; PTHR46472; NUCLEOREDOXIN; 1.
DR PANTHER; PTHR46472:SF1; NUCLEOREDOXIN; 1.
DR Pfam; PF13848; Thioredoxin_6; 1.
DR Pfam; PF13905; Thioredoxin_8; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 2.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 56..210
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
SQ SEQUENCE 324 AA; 36729 MW; 21624402A5665C90 CRC64;
IFIFVIFRDL KLWNKYRISN IPSLIFLDAT TGKVVCRNGL LVIRDDPEGL EFPWGPKPFR
EVIAGPLLRN NGQSLESSSL EGSHVGVYFS AHWCPPCRSL TRVLVESYRK IKEAGQNFEI
IFVSADRSEE SFKQYFSEMP WLAVPYTDEA RRSRLNRLYG IQGIPTLIML DPQGEVITRQ
GRVEVLNDED CREFPWHPKP VLELSDSNAA QLNEGPCLVL FVDSEDDGES EAAKQLIQPI
AEKIIAKYKA KEEEAPLLFF VAGEDDMTDS LRDYTNLPEA APLLTILDMS ARAKYVMDVE
EITPAIVEAF VNDFLAEKLK PEPI
//
