ID A0A2I3T0P3_PANTR Unreviewed; 610 AA.
AC A0A2I3T0P3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Formin-binding protein 1-like {ECO:0000256|ARBA:ARBA00019975};
DE AltName: Full=Transducer of Cdc42-dependent actin assembly protein 1 {ECO:0000256|ARBA:ARBA00032854};
GN Name=FNBP1L {ECO:0000313|Ensembl:ENSPTRP00000082423.1,
GN ECO:0000313|VGNC:VGNC:6826};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000082423.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000082423.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000082423.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Cytoplasmic vesicle
CC {ECO:0000256|ARBA:ARBA00004541}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
CC -!- SIMILARITY: Belongs to the FNBP1 family.
CC {ECO:0000256|ARBA:ARBA00009426}.
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DR EMBL; AACZ04027474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04027475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04027476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3T0P3; -.
DR Ensembl; ENSPTRT00000098268.1; ENSPTRP00000082423.1; ENSPTRG00000000970.6.
DR VGNC; VGNC:6826; FNBP1L.
DR GeneTree; ENSGT00950000183047; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000000970; Expressed in lung and 20 other cell types or tissues.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07675; F-BAR_FNBP1L; 1.
DR CDD; cd11628; HR1_CIP4_FNBP1L; 1.
DR CDD; cd12072; SH3_FNBP1L; 1.
DR Gene3D; 6.10.140.470; -; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR035494; FNBP1L_F-BAR.
DR InterPro; IPR035493; FNBP1L_SH3.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR PANTHER; PTHR15735:SF14; FORMIN-BINDING PROTEIN 1-LIKE; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51860; REM_1; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..266
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 398..475
FT /note="REM-1"
FT /evidence="ECO:0000259|PROSITE:PS51860"
FT DOMAIN 539..600
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 477..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 133..177
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 405..439
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 477..494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 610 AA; 70718 MW; AF56B7543C653861 CRC64;
KIWRLNLEDK EDQFDSLDKH TQWGIDFLER YAKFVKERIE IEQNYAKQLR NLVKKYCPKR
SSKDEEPRFT SCVAFFNILN ELNDYAGQRE VVAEEMAHRV YGELMRYAHD LKTERKMHLQ
EGRKAQQYLD MCWKQMDNSK KKFERECREA EKAQQSYERL DNDTNATKAD VEKAKQQLNL
RTHMADENKN EYAAQLQNFN GEQHKHFYVV IPQIYKQLQE MDERRTIKLS ECYRGFADSE
RKVIPIISKC LEGMILAAKS VDERRDSQMV VDSFKSGFEP PGDFPFEDYS QHIYRTISDG
TISASKQESG KMDAKTTVGK AKGKLWLFGK KPKPQSPPLT PTSLFTSSTP NGSQFLTFSI
EPVHYCMNEI KTGKPRIPSF RSLKRGVSLI MALEDFSHLP PEQRRKKLQQ RIDELNRELQ
KESDQKDALN KMKDVYEKNP QMGDPGSLQP KLAETMNNID RLRMEIHKNE AWLSEVEGKT
GGRGDRRHSS DINHLVTQGR ESPEGSYTDD ANQEVRGPPQ QHGHHNEFDD EFEDDDPLPA
IGHCKAIYPF DGHNEGTLAM KEGEVLYIIE EDKGDGWTRA RRQNGEEGYV PTSYIDVTLE
KNSKGAVTYI
//
