ID A0A2I3T3G9_PANTR Unreviewed; 795 AA.
AC A0A2I3T3G9;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Short transient receptor potential channel 1 {ECO:0000256|ARBA:ARBA00013302};
GN Name=TRPC1 {ECO:0000313|Ensembl:ENSPTRP00000083420.1,
GN ECO:0000313|VGNC:VGNC:8016};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000083420.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000083420.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000083420.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Thought to form a receptor-activated non-selective calcium
CC permeant cation channel. Probably is operated by a phosphatidylinositol
CC second messenger system activated by receptor tyrosine kinases or G-
CC protein coupled receptors. Seems to be also activated by intracellular
CC calcium store depletion. {ECO:0000256|ARBA:ARBA00003698}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. STrpC
CC subfamily. TRPC1 sub-subfamily. {ECO:0000256|ARBA:ARBA00009944}.
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DR EMBL; AACZ04048237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3T3G9; -.
DR Ensembl; ENSPTRT00000089953.1; ENSPTRP00000083420.1; ENSPTRG00000015485.6.
DR VGNC; VGNC:8016; TRPC1.
DR GeneTree; ENSGT01060000248594; -.
DR InParanoid; A0A2I3T3G9; -.
DR OMA; SRPTIVX; -.
DR Proteomes; UP000002277; Chromosome 3.
DR Bgee; ENSPTRG00000015485; Expressed in temporal lobe and 20 other cell types or tissues.
DR GO; GO:0034703; C:cation channel complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0042438; P:melanin biosynthetic process; IEA:Ensembl.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR005457; TRPC1_channel.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117:SF56; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR PRINTS; PR01642; TRPCHANNEL1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 589..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 622..644
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 195..257
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 795 AA; 91335 MW; 0F0A20D4AF935977 CRC64;
AAMMAALYPS TDLSGASSSS LPSSPSSSSP NEVMALKDVR EVKEENTLNE KLFLLACDKG
DYYMVKKILE ENSSGDLNIN CVDVLGRNAV TITIENENLD ILQLLLDYGC QSADALLVAI
DSEVVGAVDI LLNHRPKRSS RPTIVKLMER IQNPEYSTTM DVAPVILAAH HNNYEILTML
LKQDVSLPKP HAVGCECTLC SAKNKKDSLR HSRFRLDIYR CLASPALIML TEEDPILRAF
ELSADLKELS LVEVEFRNDY EELARQCKMF AKDLLAQARN SRELEVILNH TSSDEPLDKR
GLLEERMNLS RLKLAIKYNQ KEFVSQSNCQ QFLNTVWFGQ MSGYRRKPTC KKIMTVLTVG
IFWPVLSLCY LIAPKSQFGR IIHTPFMKFI IHGASYFTFL LLLNLYSLVY NEDKKNTMGP
ALERIDYLLI LWIIGMIWSD IKRLWYEGLE DFLEESRNQL SFVMNSLYLA TFALKVVAHN
KFHDFADRKD WDAFHPTLVA EGLFAFANVL SYLRLFFMYT TSSILGPLQI SMGQMLQDFG
KFLGMFLLVL FSFTIGLTQL YDKGYTSKEQ KDCVGIFCEQ QSNDTFHSFI GTCFALFWYI
FSLAHVAIFV TRFSYGEELQ SFVGAVIVGT YNVVVVIVLT KLLVAMLHKS FQLIANHEDK
EWKFARAKLW LSYFDDKCTL PPPFNIIPSP KTICYMISSL SKWICSHTSK GKVKRQNSLK
EWRNLKQKRD ENYQKVMCCL VHRYLTSMRQ KMQSTDQATV ENLNELRQDL SKFRNEIRDL
LGFRTSKYAM FYPRN
//
