ID A0A2I3T4H4_PANTR Unreviewed; 61 AA.
AC A0A2I3T4H4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Metallothionein {ECO:0000256|RuleBase:RU000621};
GN Name=MT1HL1 {ECO:0000313|Ensembl:ENSPTRP00000084133.1,
GN ECO:0000313|VGNC:VGNC:84251};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000084133.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000084133.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000084133.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Metallothioneins have a high content of cysteine residues
CC that bind various heavy metals; these proteins are transcriptionally
CC regulated by both heavy metals and glucocorticoids.
CC {ECO:0000256|ARBA:ARBA00002597}.
CC -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 1 family.
CC {ECO:0000256|ARBA:ARBA00007283, ECO:0000256|RuleBase:RU000621}.
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DR EMBL; AACZ04026658; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3T4H4; -.
DR Ensembl; ENSPTRT00000083526.1; ENSPTRP00000084133.1; ENSPTRG00000043308.1.
DR VGNC; VGNC:84251; MT1HL1.
DR GeneTree; ENSGT00950000182967; -.
DR InParanoid; A0A2I3T4H4; -.
DR OMA; ASEKCRC; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000043308; Expressed in liver.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IBA:GO_Central.
DR GO; GO:0071276; P:cellular response to cadmium ion; IBA:GO_Central.
DR GO; GO:0071280; P:cellular response to copper ion; IBA:GO_Central.
DR GO; GO:0071294; P:cellular response to zinc ion; IBA:GO_Central.
DR GO; GO:0010273; P:detoxification of copper ion; IBA:GO_Central.
DR GO; GO:0006882; P:intracellular zinc ion homeostasis; IBA:GO_Central.
DR Gene3D; 4.10.10.10; Metallothionein Isoform II; 1.
DR InterPro; IPR017854; Metalthion_dom_sf.
DR InterPro; IPR023587; Metalthion_dom_sf_vert.
DR InterPro; IPR000006; Metalthion_vert.
DR PANTHER; PTHR23299; METALLOTHIONEIN; 1.
DR PANTHER; PTHR23299:SF63; METALLOTHIONEIN 1H-LIKE PROTEIN 1-RELATED; 1.
DR Pfam; PF00131; Metallothio; 1.
DR PRINTS; PR00860; MTVERTEBRATE.
DR SUPFAM; SSF57868; Metallothionein; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000621};
KW Metal-thiolate cluster {ECO:0000256|ARBA:ARBA00022851,
KW ECO:0000256|RuleBase:RU000621};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
SQ SEQUENCE 61 AA; 6053 MW; E60AAD769AC0B9A1 CRC64;
MDPNCSCAAG GSYACAGSCK CKKCKCISCK KSCCSCCPLG CAKCAQGCIC KGASEKCSCC
A
//
