ID A0A2I3T4Y7_PANTR Unreviewed; 867 AA.
AC A0A2I3T4Y7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=dynamin GTPase {ECO:0000256|ARBA:ARBA00011980};
DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
GN Name=DNM1 {ECO:0000313|Ensembl:ENSPTRP00000084297.1,
GN ECO:0000313|VGNC:VGNC:4677};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000084297.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000084297.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000084297.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC192633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC195639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPTRT00000090326.1; ENSPTRP00000087142.1; ENSPTRG00000051673.1.
DR Ensembl; ENSPTRT00000104295.1; ENSPTRP00000084297.1; ENSPTRG00000021418.6.
DR VGNC; VGNC:4677; DNM1.
DR GeneTree; ENSGT00940000155214; -.
DR Proteomes; UP000002277; Chromosome 9.
DR Bgee; ENSPTRG00000021418; Expressed in dorsolateral prefrontal cortex and 16 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0031623; P:receptor internalization; IBA:GO_Central.
DR GO; GO:0048488; P:synaptic vesicle endocytosis; IBA:GO_Central.
DR CDD; cd08771; DLP_1; 1.
DR CDD; cd01256; PH_dynamin; 1.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF32; DYNAMIN-1; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00302; GED; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 28..291
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 512..618
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 652..743
FT /note="GED"
FT /evidence="ECO:0000259|PROSITE:PS51388"
FT REGION 760..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 760..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..833
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 867 AA; 97549 MW; 0BC61742066C7F11 CRC64;
MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN FVDENPQVGF
QTLMPTALPL PASGAEYAEF LHCKGKKFTD FEEVRLEIEA ETDRVTGTNK GISPVPINLR
VYSPHVLNLT LVDLPGMTKV PVGDQPPDIE FQIRDMLMQF VTKENCLILA VSPANSDLAN
SDALKVAKEV DPQGQRTIGV ITKLDLMDEG TDARDVLENK LLPLRRGYIG VVNRSQKDID
GKKDITAALA AERKFFLSHP SYRHLADRMG TPYLQKVLNQ QLTNHIRDTL PGLRNKLQSQ
LLSIEKEVEE YKNFRPDDPA RKTKALLQMV QQFAVDFEKR IEGSGDQIDT YELSGGARIN
RIFHERFPFE LVKMEFDEKE LRREISYAIK NIHGIRTGLF TPDMAFETIV KKQVKKIREP
CLKCVDMVIS ELISTVRQCT KKLQQYPRLR EEMERIVTTH IREREGRTKE QVMLLIDIEL
AYMNTNHEDF IGFANAQQRS NQMNKKKTSG NQVIRKGWLT INNIGIMKGG SKEYWFVLTA
ENLSWYKDDE EKEKKYMLSV DNLKLRDVEK GFMSSKHIFA LFNTEQRNVY KDYRQLELAC
ETQEEVDSWK ASFLRAGVYP ERVGVSGRAS ETEENGSDSF MHSMDPQLER QVETIRNLVD
SYMAIVNKTV RDLMPKTIMH LMINNTKEFI FSELLANLYS CGDQNTLMEE SAEQAQRRDE
MLRMYHALKE ALSIIGDINT TTVSTPMPPP VDDSWLQVQS VPAGRRSPTS SPTPQRRAPA
VPPARPGSRG PAPGPPPAGS ALGGAPPVPS RPGASPDPFG PPPQVPSRPN RAPPGPGGSW
NRLRAQAGRH GCSLEPSERA ESSWFMV
//
