ID A0A2I3T5K3_PANTR Unreviewed; 456 AA.
AC A0A2I3T5K3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=glucose-6-phosphate dehydrogenase (NADP(+)) {ECO:0000256|ARBA:ARBA00013019};
DE EC=1.1.1.49 {ECO:0000256|ARBA:ARBA00013019};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000084510.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000084510.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-
CC lactone + H(+) + NADPH; Xref=Rhea:RHEA:15841, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:57955, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:61548; EC=1.1.1.49;
CC Evidence={ECO:0000256|ARBA:ARBA00001220};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15842;
CC Evidence={ECO:0000256|ARBA:ARBA00001220};
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC 1/3. {ECO:0000256|ARBA:ARBA00004937}.
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DR AlphaFoldDB; A0A2I3T5K3; -.
DR Ensembl; ENSPTRT00000082057.1; ENSPTRP00000084510.1; ENSPTRG00000042671.1.
DR GeneTree; ENSGT00530000063435; -.
DR InParanoid; A0A2I3T5K3; -.
DR UniPathway; UPA00115; -.
DR Proteomes; UP000002277; Unplaced.
DR Bgee; ENSPTRG00000042671; Expressed in bone marrow and 7 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006006; P:glucose metabolic process; IBA:GO_Central.
DR GO; GO:0009051; P:pentose-phosphate shunt, oxidative branch; IBA:GO_Central.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001282; G6P_DH.
DR InterPro; IPR022675; G6P_DH_C.
DR InterPro; IPR022674; G6P_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23429:SF0; GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE; 1.
DR PANTHER; PTHR23429; GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD; 1.
DR Pfam; PF02781; G6PD_C; 1.
DR Pfam; PF00479; G6PD_N; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Glucose metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 65..154
FT /note="Glucose-6-phosphate dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF00479"
FT DOMAIN 228..444
FT /note="Glucose-6-phosphate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02781"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 456 AA; 51657 MW; 7A076BCA063DC7F5 CRC64;
MGRRGSAPGN GRTLRGCERG GRRRRSADSV MAEQVALSRT QVCGILREEL FQGDAFHQSD
THIFIIMGAS VSISQAPILK ARKWLFRDGL LPENTFIVGY ARSRLTVADI RKQSEPFFKA
PQRRSSSCED FFRPQSYVAG QYDECSSYQP LTRPQNALHL GSQCQPTFTK SSCSQMYKAC
RCPPFPPARL AAKQRAFPCP EGLHILAATV IHCHPKHPRS PFSPLAFSQV KVLKCISEVQ
ANNVVLGQYV GNPDGEGEAT KGYLDDPTVP RGSTTATFAA VVLYVENERW DGVPFILRCG
KALNERKAEV RLQFHDVAGD IFHQQCKRNE LVIRVQPNEA VYTKMMTKKP GMFFNPEESE
LDLTYGNRYK DVKLPDAYER LILDVFCGSQ MHFVRSDELR EAWRIFTPLL HQIELEKPKP
IPYIYGSRGP TEADELMKRV GFQYEGTYKW VNPHKL
//
