ID A0A2I3T5N9_PANTR Unreviewed; 123 AA.
AC A0A2I3T5N9;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Ras-related protein Rab {ECO:0000256|RuleBase:RU367128};
GN Name=RAB38 {ECO:0000313|Ensembl:ENSPTRP00000084559.1,
GN ECO:0000313|VGNC:VGNC:7662};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000084559.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000084559.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000084559.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: The small GTPases Rab are key regulators in vesicle
CC trafficking. {ECO:0000256|RuleBase:RU367128}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU367128}; Lipid-
CC anchor {ECO:0000256|RuleBase:RU367128}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000256|ARBA:ARBA00006270, ECO:0000256|RuleBase:RU367128}.
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DR EMBL; AACZ04016359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3T5N9; -.
DR Ensembl; ENSPTRT00000107801.1; ENSPTRP00000084559.1; ENSPTRG00000004151.4.
DR VGNC; VGNC:7662; RAB38.
DR GeneTree; ENSGT00940000157301; -.
DR Proteomes; UP000002277; Chromosome 11.
DR Bgee; ENSPTRG00000004151; Expressed in fibroblast and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:UniProtKB-UniRule.
DR GO; GO:0031982; C:vesicle; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd04107; Rab32_Rab38; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR030697; Rab29/Rab38/Rab32.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR24073; DRAB5-RELATED; 1.
DR PANTHER; PTHR24073:SF839; RAS-RELATED PROTEIN RAB-38; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|RuleBase:RU367128};
KW Lipoprotein {ECO:0000256|RuleBase:RU367128};
KW Membrane {ECO:0000256|RuleBase:RU367128};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU367128};
KW Prenylation {ECO:0000256|RuleBase:RU367128};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
SQ SEQUENCE 123 AA; 14296 MW; 14F35EC3F5A7D9E6 CRC64;
MQAPHKEHLY KLLVIGDLGV GKTSIIKRYV HQNFSSHYRA TIGVDFALKV LHWDPETVVR
LQLWDIAGQE RFGNMTRVYY REAMGAFIVF DVTRPATFEA VAKWKNDLDS KLSLPNEIHH
HKH
//
