ID   A0A2I3T6J7_PANTR        Unreviewed;       697 AA.
AC   A0A2I3T6J7;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Programmed cell death 6 {ECO:0000313|Ensembl:ENSPTRP00000084817.1};
GN   Name=PDCD6 {ECO:0000313|Ensembl:ENSPTRP00000084817.1,
GN   ECO:0000313|VGNC:VGNC:4123};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000084817.1, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000084817.1, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000084817.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AACZ04068238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC191766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016808364.1; XM_016952875.1.
DR   AlphaFoldDB; A0A2I3T6J7; -.
DR   Ensembl; ENSPTRT00000109793.1; ENSPTRP00000084817.1; ENSPTRG00000028788.4.
DR   GeneID; 461687; -.
DR   CTD; 57491; -.
DR   VGNC; VGNC:4123; PDCD6.
DR   GeneTree; ENSGT00940000154486; -.
DR   OrthoDB; 5360131at2759; -.
DR   Proteomes; UP000002277; Chromosome 5.
DR   Bgee; ENSPTRG00000028788; Expressed in cerebellar cortex and 21 other cell types or tissues.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0006805; P:xenobiotic metabolic process; IEA:InterPro.
DR   CDD; cd11435; bHLH-PAS_AhRR; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR039091; AHR/AHRR.
DR   InterPro; IPR039092; AHRR_bHLH.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   PANTHER; PTHR10649; ARYL HYDROCARBON RECEPTOR; 1.
DR   PANTHER; PTHR10649:SF3; ARYL HYDROCARBON RECEPTOR REPRESSOR; 1.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF00989; PAS; 1.
DR   SMART; SM00353; HLH; 1.
DR   SMART; SM00091; PAS; 1.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT   DOMAIN          24..77
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          113..178
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          362..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          445..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        367..381
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   697 AA;  76038 MW;  4AF3F20A9F5B7977 CRC64;
     MIPPGECTYA GRKRRRPLQK QRPAVGAEKS NPSKRHRDRL NAELDHLASL LPFPPEIISK
     LDKLSVLRLS VSYLRVKSFF QVVQEQSSRQ PAAGAPSPGD SCPLAGSAVL EGRLLLESLN
     GFALVVSAEG TIFYASATIV DYLGFHQTDV MHQNIYDYIH VDDRQDFCRQ LHWAMDPPQV
     VFGQPPPLET GDDAILGRLL RAQEWGTGTP TEYSAFLTRC FICRVRCLLD STSGFLTMQF
     QGKLKFLFGQ KRKAPSGAML PPRLSLFCIA APVLLPSAAE MKMRSALLRA KPRADTAATT
     DAKVKATTSL CESELHGKPN YSAGRSSRES GVLVLREQTD ADRWAQVPAR APCLCLRGGP
     DLVLDPKGGS GDREEEQHRM LSRASGVTGR RETPGPTKPL PWTVGKHSED GARPRLQPSK
     NDPRSLRPMP RGSCLPYPCV QGTFRNSPIS HPPSPSPSAY SSRTSRPVRE VGEDQVHPPL
     CHFPQGSLQH QLPQPGAQRF ATRGYPMEDV KLQGVPMPPG DLCGPTLLLD VSIKMEKDSG
     CEDAADGCVP SQVWLGASDR SHPATFPTRM HLKTEPDSRQ QVYISHLGHG VRGAQPHGRA
     TAGRSRELTP FHPAHCACLE TTHGLPQSEP PHQLCARGRG EQSCTCRDAE AAPVVKREPL
     DSPQWATHSQ GVVPGMFPKS ALATLVPPQA SGCTFLP
//