ID A0A2I3T6V4_PANTR Unreviewed; 1298 AA.
AC A0A2I3T6V4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Semaphorin 5B {ECO:0000313|Ensembl:ENSPTRP00000084980.1};
GN Name=SEMA5B {ECO:0000313|Ensembl:ENSPTRP00000084980.1,
GN ECO:0000313|VGNC:VGNC:7122};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000084980.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000084980.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000084980.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AACZ04048120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPTRT00000108808.1; ENSPTRP00000084980.1; ENSPTRG00000015301.5.
DR VGNC; VGNC:7122; SEMA5B.
DR GeneTree; ENSGT00940000156712; -.
DR Proteomes; UP000002277; Chromosome 3.
DR Bgee; ENSPTRG00000015301; Expressed in primary visual cortex and 8 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd11264; Sema_5B; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 6.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF39; SEMAPHORIN-5B; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF00090; TSP_1; 5.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SMART; SM00209; TSP1; 5.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR PROSITE; PS51004; SEMA; 1.
DR PROSITE; PS50092; TSP1; 5.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1181..1204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 250..700
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1298 AA; 140206 MW; D54FA529ABBE62CA CRC64;
MPAGEGASAH RAGHHTRQAR GGSRPSSRGM QGAPSRSSAR LEAGGCSARR GRSAPAPSSF
SLPLPSFSPF ACNSSPTAPS LLLLPRSPPP CCLRAPGREL VGARGLVPEP SSAEPGGSAA
RPAAAGSPSA AGAGPGRDCT GALRAGGRSC AAAPFPDRPP AHLVRSRRSA PPGSREPRGT
GHLHPPLGGF LPCLPPGART AEGPIMVLAG PLAVSLLLPS LTLLVSHLSS SQDVSSEPSS
EQQLCALSEH PTVAFEDLQP WVSNFTYPGA RDFSQLALDP SRNQLIVGAR NYLFRLSLAN
VSLLQATEWA SSEDTRRSCQ SKGKTEEECQ NYVRVLIVAG RKVFMCGTNA FSPMCTSRQV
GNLSRTVEKI NGVARCPYDP RHNSTAVISS QGELYAATVI DFSGRDPAIY RSLGSGPPLR
TAQYNSKWLN EPNFVAAYDI GLFAYFFLRE NAVEHDCGRT VYSRVARVCK NDVGGRFLLE
DTWTTFMKAR LNCSRPGEVP FYYNELQSAF HLPEQDLIYG VFTTNVNSIA ASAVCAFNLS
AISQAFNGPF RYQENPRAAW LPIANPIPNF QCGTLPETGP NENLTERSLQ DAQRLFLMSE
AVQPVTPEPC VTQDSVRFSH LVVDLVQAKD TLYHVLYIGT ESGTILKALS TASRSLHGCY
LEELHVLPPG RREPLRSLRI LHSARALFVG LSDGVLRVPL ERCAAYRSQG ACLGARDPYC
GWDGKQQRCS TLEDSSNMSL WTQNITACPV RNVTRDGGFG PWSPWQPCEH LDGDNSGSCL
CRARSCDSPR PRCGGLDCLG PAIHIANCSR NGAWTPWSSW ALCSTSCGIG FQVRQRSCSN
PAPRHGGRIC VGKSREERFC NENTPCPVPI FWASWGSWSK CSSNCGGGVQ SRRRACENGN
SCLGCGVEFK TCNPEGCPEV RRNTPWTPWL PVNVTQGGAR QEQRFRFTCR APLADPHGLQ
FGRRRTETRT CPADGSGSCD TDALVEDLLR SGSTSPHTVS GGWAAWGPWS SCSRDCELGF
RVRKRTCTNP EPRNGGLPCV GDAAEYQDCN PQACPVRGAW SCWTSWSPCS ASCGGGHYQR
TRSCTSPAPS PGEDICLGLH TEEALCATQA CPEGWSPWSE WSKCTDDGAQ SRSRHCEELL
PGPSACAGNS SQSRPCPYSE IPVILPASSM EEATGCAGFN LIHLVATGIS CFLGSGLLTL
AVYLSCQHCQ RQSQESTLVH PATPNHLHYK GGGTPKNEKY TPMEFKTLNK NNLIPDDRAN
FYPLQQTNVY TTTYYPSPLN KHSFRPEASP GQRCFPNS
//
