ID A0A2I3T6Y4_PANTR Unreviewed; 1204 AA.
AC A0A2I3T6Y4; A0A2J8P1C6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Fibronectin type III domain containing 3B {ECO:0000313|EMBL:JAA09395.1, ECO:0000313|Ensembl:ENSPTRP00000085005.1};
GN Name=FNDC3B {ECO:0000313|EMBL:JAA09395.1,
GN ECO:0000313|Ensembl:ENSPTRP00000085005.1,
GN ECO:0000313|VGNC:VGNC:11973};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000085005.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000085005.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA09395.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA09395.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA40171.1}, Skin {ECO:0000313|EMBL:JAA32753.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA21983.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000085005.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FNDC3 family.
CC {ECO:0000256|ARBA:ARBA00038207}.
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DR EMBL; AACZ04067224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04067225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04067226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01001943; JAA09395.1; -; mRNA.
DR EMBL; GABC01001942; JAA09396.1; -; mRNA.
DR EMBL; GABF01000162; JAA21983.1; -; mRNA.
DR EMBL; GABF01000161; JAA21984.1; -; mRNA.
DR EMBL; GABF01000160; JAA21985.1; -; mRNA.
DR EMBL; GABF01000159; JAA21986.1; -; mRNA.
DR EMBL; GABF01000158; JAA21987.1; -; mRNA.
DR EMBL; GABF01000157; JAA21988.1; -; mRNA.
DR EMBL; GABD01000347; JAA32753.1; -; mRNA.
DR EMBL; GABD01000346; JAA32754.1; -; mRNA.
DR EMBL; GABD01000345; JAA32755.1; -; mRNA.
DR EMBL; GABE01004568; JAA40171.1; -; mRNA.
DR RefSeq; XP_001165324.1; XM_001165324.5.
DR RefSeq; XP_016797785.1; XM_016942296.1.
DR STRING; 9598.ENSPTRP00000085005; -.
DR PaxDb; 9598-ENSPTRP00000026892; -.
DR Ensembl; ENSPTRT00000110615.1; ENSPTRP00000085005.1; ENSPTRG00000015629.6.
DR GeneID; 460850; -.
DR KEGG; ptr:460850; -.
DR CTD; 64778; -.
DR VGNC; VGNC:11973; FNDC3B.
DR GeneTree; ENSGT00940000157005; -.
DR OrthoDB; 316463at2759; -.
DR TreeFam; TF316401; -.
DR Proteomes; UP000002277; Chromosome 3.
DR Bgee; ENSPTRG00000015629; Expressed in bone marrow and 22 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 9.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR24099; E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED; 1.
DR PANTHER; PTHR24099:SF11; FIBRONECTIN TYPE III DOMAIN-CONTAINING 3BA-RELATED; 1.
DR Pfam; PF00041; fn3; 8.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 9.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR PROSITE; PS50853; FN3; 9.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1179..1202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 278..377
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 381..473
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 477..570
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 574..669
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 673..765
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 766..859
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 871..957
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 958..1052
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1056..1153
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 185..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 567..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1204 AA; 132857 MW; AF70184FB7639668 CRC64;
MYVTMMMTDQ IPLELPPLLN GEVAMMPHLV NGDAAQQVIL VQVNPGETFT IRAEDGTLQC
IQGPAEVPMM SPNGSIPPIH VPPGYISQVI EDSTGVRRVV VTPQSPECYP PSYPSAMSPT
HHLPPYLTHH PHFIHNSHTA YYPPVTGPGD MPPQFFPQHH LPHTIYGEQE IIPFYGMSSY
ITREDQYSKP PHKKLKDRQI DRQNRLNSPP SSIYKSSCTT VYNGYGKGHS GGSGGGGSGG
GPGIKKTERR ARSSPKSNDS DLQEYELEVK RVQDILSGIE KPQVSNIQAR AVVLSWAPPV
GLSCGPHSGL SFPYSYEVAL SDKGRDGKYK IIYSGEELEC NLKDLRPATD YHVRVYAMYN
SVKGSCSEPV SFTTHSCAPE CPFPPKLAHR SKSSLTLQWK APIDNGSKIT NYLLEWDEGK
RNSGFRQCFF GSQKHCKLTK LCPAMGYTFR LAARNDIGTS GYSQEVVCYT LGNIPQMPSA
PRLVRAGITW VTLQWSKPEG CSPEEVITYT LEIQEDENDN LFHPKYTGED LTCTVKNLKR
STQYKFRLTA SNTEGKSCPS EVLVCTTSPD RPGPPTRPLV RGPVTSHGFS VKWDPPKDNG
GSEILKYLLE ITDGNSEANQ WEVAYSGSAT EYTFTHLKPG TLYKLRACCI STGGHSQCSE
SLPVRTLSIA PGQCRPPRVL GRPKHKEVHL EWDVPASESG CEVSEYSVEM TEPEDVASEV
YHGPELECTV GNLLPGTVYH FRVRALNDGG YGPYSDVSEI TTAAGPPGQC KAPCISCTPD
GCVLVGWESP DSSGADISEY RLEWGEDEES LELIYHGTDT RFEIRDLLPA AQYCCRLQAF
NQAGAGPYSE LVLCQTPASA PDPVSTLCVL EEEPLDAYPD SPSACLVLNW EEPCNNGSEI
LAYTIDLGDT SITVGNTTMH VMKDLLPETT YRIRIQAINE IGAGPFSQFI KAKTRPLPPL
PPRLECAAAG PQSLKLKWGD SNSKTHAADD MVYTLQLEDR NKRFISIYRG PSHTYKVQRL
TEFTCYSFRI QAASEAGEGP FSETYTFSTT KSVPPTIKAP RVTQLEGNSC EILWETVPSM
KGDPVNYILQ VLVGRESEYK QVYKGEEATF QISGLQTNTD YRFRVCACRR CLDTSQELSG
AFSPSAAFVL QRSEVMLTGD MGSLDDPKMK SMMPTDEQFA AIIVLGFATL SILFAFILQY
FLMK
//
