ID   A0A2I3T7M5_PANTR        Unreviewed;      1145 AA.
AC   A0A2I3T7M5;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=SKI2 subunit of superkiller complex {ECO:0000313|Ensembl:ENSPTRP00000084883.1};
GN   Name=SKIC2 {ECO:0000313|Ensembl:ENSPTRP00000084883.1,
GN   ECO:0000313|VGNC:VGNC:52098};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000084883.1, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000084883.1, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000084883.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AACZ04022804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2I3T7M5; -.
DR   Ensembl; ENSPTRT00000110928.1; ENSPTRP00000084883.1; ENSPTRG00000017997.5.
DR   VGNC; VGNC:52098; SKIC2.
DR   GeneTree; ENSGT00940000158255; -.
DR   OMA; CGSDITR; -.
DR   Proteomes; UP000002277; Chromosome 6.
DR   Bgee; ENSPTRG00000017997; Expressed in primary visual cortex and 21 other cell types or tissues.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR   CDD; cd18027; DEXHc_SKIV2L; 1.
DR   CDD; cd18795; SF2_C_Ski2; 1.
DR   Gene3D; 1.10.3380.30; -; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR048392; MTR4-like_stalk.
DR   InterPro; IPR025696; MTR4_beta-barrel.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016438; SKI2-like.
DR   InterPro; IPR012961; Ski2/MTR4_C.
DR   PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR   PANTHER; PTHR12131:SF8; HELICASE SKI2W; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF08148; DSHCT; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF21408; MTR4-like_stalk; 1.
DR   Pfam; PF13234; MTR4_beta-barrel; 1.
DR   PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01142; DSHCT; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT   DOMAIN          218..374
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          484..654
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          119..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1145 AA;  126986 MW;  CA63BB6A303F6F55 CRC64;
     MASLLVPQIC SKKQNSCFCH PQPGCLCMVW STQPENGRGR RIPGLFWLSW EPQSHPTYRP
     KDTQPQARYW EAEEEIDFEK DLLTIPPGFK KGMDFAPKDC PTPAPGLLSL SCLLEPLDLG
     GGDEDENEAV GQPGGPRGDA VSASPCSAPL ARASSLEDLV LKEASTAVST PEAPEPPSQE
     QWAIPVDATS PVGDFYRLIP QPAFQWAFEP DVFQKQAILH LERHDSVFVA AHTSAGKTVV
     AEYAIALAQK HMTRTIYTSP IKALSNQKFR DFRNTFGDVG LLTGDVQLHP EASCLIMTTE
     ILRSMLYSGS DVIRDLEWVI FDEVHYINDA ERGVVWEEVL IMLPDHVSII LLSATVPNAL
     EFADWIGRLK RRQIYVISTV TRPVPLEHYL FTGNSSKTQG ELFLLLDSRG AFHTKGYYAA
     VEAKKERMSK HAQTFGAKQP THQGGPAQDR GVYLSLLASL RTRAQLPVVV FTFSRGRCDE
     QASGLTSLDL TTSSEKSEIH LFLQRCLARL RGSDRQLPQV LHMSELLNRG LGVHHSGILP
     ILKEIVEMLF SRGLVKVLFA TETFAMGVNM PARTVVFDSM RKHDGSTFRD LLPGEYVQMA
     GRAGRRGLDP TGTVILLCKG RVPEMADLHR MMMGKPSQLQ SQFRLTYTMI LNLLRVDALR
     VEDMMKRSFS EFPSRKDSKA HEQALAELTK KLGALEEPDM TGQLVDLPEY YSWGEELTET
     QHMIQRRIME SVNGLKSLSA GRVVVVKNQE HHNALGVILQ VSSNSTSRVF TTLVLCDKPL
     SQDPQDRGPA TAEVAYPDDL VGFKLFLPEG PCDHTVVKLQ PGDMAAITTK VLRVNGEKIL
     EDFSKRQQPK FKKDPPLAAV TTAVQELLRL AQAHPAGPPT LDPVNDLQLK DMSVVEGGLR
     ARKLEELIQG AQCVHSPRFP AQYLKLRERM QIQKEMERLR FLLSDQSLLL LPEYHQRVEV
     LRTLGYVDEA GTVKLAGRVA CAMSSHELLL TELMFDNALS TLRPEEIAAL LSGLVCQSPG
     DAGDQLPNTL KQGIERVRAV AKRIGEVQVA CGLNQTVEEF VGELNFGLVE VVYEWARGMP
     FSELAGLSGT PEGLVVRCIQ RLAEMCRSLR GAARLVGEPV LGAKMETAAT LLRRDIVFAA
     SLYTQ
//