ID A0A2I3T9M4_PANTR Unreviewed; 1229 AA.
AC A0A2I3T9M4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Adenosine deaminase RNA specific {ECO:0000313|Ensembl:ENSPTRP00000085936.1};
GN Name=ADAR {ECO:0000313|Ensembl:ENSPTRP00000085936.1,
GN ECO:0000313|VGNC:VGNC:27};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000085936.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000085936.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000085936.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04025341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3T9M4; -.
DR PaxDb; 9598-ENSPTRP00000043065; -.
DR Ensembl; ENSPTRT00000104637.1; ENSPTRP00000085936.1; ENSPTRG00000022833.4.
DR VGNC; VGNC:27; ADAR.
DR GeneTree; ENSGT00940000157243; -.
DR InParanoid; A0A2I3T9M4; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000022833; Expressed in spleen and 21 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0044530; C:supraspliceosomal complex; IEA:Ensembl.
DR GO; GO:0003726; F:double-stranded RNA adenosine deaminase activity; IBA:GO_Central.
DR GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0008251; F:tRNA-specific adenosine deaminase activity; IBA:GO_Central.
DR GO; GO:0006382; P:adenosine to inosine editing; IBA:GO_Central.
DR GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR GO; GO:0060216; P:definitive hemopoiesis; IEA:Ensembl.
DR GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0061484; P:hematopoietic stem cell homeostasis; IEA:Ensembl.
DR GO; GO:0097284; P:hepatocyte apoptotic process; IEA:Ensembl.
DR GO; GO:1903944; P:negative regulation of hepatocyte apoptotic process; IEA:Ensembl.
DR GO; GO:1900369; P:negative regulation of post-transcriptional gene silencing by regulatory ncRNA; IEA:Ensembl.
DR GO; GO:0060339; P:negative regulation of type I interferon-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0045070; P:positive regulation of viral genome replication; IEA:Ensembl.
DR GO; GO:0031054; P:pre-miRNA processing; IEA:Ensembl.
DR GO; GO:0035455; P:response to interferon-alpha; IEA:Ensembl.
DR GO; GO:0070922; P:RISC complex assembly; IEA:Ensembl.
DR GO; GO:0006396; P:RNA processing; IBA:GO_Central.
DR GO; GO:0002566; P:somatic diversification of immune receptors via somatic mutation; IEA:Ensembl.
DR CDD; cd19913; DSRM_DRADA_rpt1; 1.
DR CDD; cd19914; DSRM_DRADA_rpt2; 1.
DR CDD; cd19915; DSRM_DRADA_rpt3; 1.
DR Gene3D; 3.30.160.20; -; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR002466; A_deamin.
DR InterPro; IPR044456; ADAR1_DSRM_1.
DR InterPro; IPR044457; ADAR1_DSRM_3.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR042371; Z_dom.
DR PANTHER; PTHR10910:SF107; DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE; 1.
DR PANTHER; PTHR10910; EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN; 1.
DR Pfam; PF02137; A_deamin; 1.
DR Pfam; PF00035; dsrm; 3.
DR Pfam; PF02295; z-alpha; 2.
DR SMART; SM00552; ADEAMc; 1.
DR SMART; SM00358; DSRM; 3.
DR SMART; SM00550; Zalpha; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 3.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR PROSITE; PS50137; DS_RBD; 3.
DR PROSITE; PS50139; Z_BINDING; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}.
FT DOMAIN 136..202
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 296..360
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 506..574
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 617..685
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 729..797
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 889..1224
FT /note="A to I editase"
FT /evidence="ECO:0000259|PROSITE:PS50141"
FT REGION 211..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..600
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1229 AA; 136378 MW; FD2A15B37BF9970A CRC64;
MRPRLSRKGY SLNGYYTHPF QGYEHRQLRY QQPGPGSSPS SFLLKQIEFL KGQLPEAPVI
GKQTPSLPPS LPGLRPRFPV LLASSTRGRQ VDIRGVPRGV HLGSQGLQRG FQHPSPRGRS
LPQRGVDCLS SHFQELSIYQ DQEQRILKFL EELGEGKATT AHDLSGKLGT PKKEINRVLY
SLAKKGKLQK EAGTPPLWKI AVSTQAWNQH SGVVRPDGHS QGAPNSDPSL EPEDRNSTSV
SEDLLEPFIA VSAQAWNEHS GVVRPDGHSQ GSPNSDPGLE PEDSNSTSAL EDPLEFLDMA
EIKEKICDYL FNVSDSSALN LAKNIGLTKA RDINAVLIDM ERQGDVYRQG TTPPIWHLTD
KKRERMQIKR NTNSVPETAP AAIPETKRNA EFLTCNIPTS NASNNMVTTE KVENGQEPVI
KLENRQEARP EPVRLKPPVH YNGPSKAGYV DFENGQWATD DIPDDLNSIR AAPGEFRAIM
EMPSFYSHGL PRCSPYKKLT ECQLKNPISG LLEYAQFASQ TCEFNMIEQS GPPHEPRFKF
QVVINGREFP PAEAGSKKVA KQDAAMKAMT ILLEEAKAKD SGKSEESSHY STEKESEKTA
ESQTPTPSAT SFFSGKSPVT TLLECMHKLG NSCEFRLLSK EGPAHEPKFQ YCVAVGAQTF
PSVSAPSKKV AKQMAAEEAM KALHGEATNS MASDNQPEGM ISESLDNLES MMPNKVRKIG
ELVRYLNTNP VGGLLEYARS HGFAAEFKLV DQSGPPHEPK FVYQAKVGGR WFPAVCAHSK
KQGKQEAADA ALRVLIGENE KAERMGFTEV TPVTGASLRR TMLLLSRSPE AQPKTLPLTG
STFHDQIAML SHRCFNTLTN SFQPSLLGRK ILAAIIMKKD SEDMGVVVSL GTGNRCVKGD
SLSLKGETVN DCHAEIISRR GFIRFLYSEL MKYNSQTAKD SIFEPAKGGE KLQIKKTVSF
HLYISTAPCG DGALFDKSCS DRAMESTESR HYPVFENPKQ GKLRTKVENG EGTIPVESSD
IVPTWDGIRL GERLRTMSCS DKILRWNVLG LQGALLTHFL QPIYLKSVTL GYLFSQGHLT
RAICCRVTRD GSAFEDGLRH PFIVNHPKVG RVSVYDSKRQ SGKTKETSVN WCLADGYDLE
ILDGTRGTVD GPRNELSRVS KKNIFLLFKK LCSFRYRRDL LRLSYGEAKK AARDYETAKN
YFKKGLKDMG YGNWISKPQE EKNFYLCPV
//
