ID A0A2I3T9R5_PANTR Unreviewed; 1807 AA.
AC A0A2I3T9R5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Kinesin family member 13B {ECO:0000313|Ensembl:ENSPTRP00000085995.1};
GN Name=KIF13B {ECO:0000313|Ensembl:ENSPTRP00000085995.1,
GN ECO:0000313|VGNC:VGNC:847};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000085995.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000085995.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000085995.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; AACZ04065629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04065630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04065631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04065632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04065633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPTRT00000083116.1; ENSPTRP00000085995.1; ENSPTRG00000023437.5.
DR VGNC; VGNC:847; KIF13B.
DR GeneTree; ENSGT00940000155500; -.
DR Proteomes; UP000002277; Chromosome 8.
DR Bgee; ENSPTRG00000023437; Expressed in spleen and 21 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22730; FHA_KIF13B; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF5; -; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF12473; DUF3694; 2.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM01052; CAP_GLY; 1.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 1..339
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 1702..1744
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 533..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1560..1630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1643..1679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1577..1605
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 89..96
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1807 AA; 200697 MW; 146F656068F86BE6 CRC64;
ETDLHTKCVV DVDANKVILN PVNTNLSKGD ARGQPKVRDL VFAYDHCFWS MDESVKEKYA
GQDIVFKCLG ENILQNAFDG YNACIFAYGQ TGSGKSYTMM GTADQPGLIP RLCSGLFERT
QKEENEEQSF KVEVSYMEIY NEKVRDLLDP KGSRQTLKVR EHSVLGPYVD GLSKLAVTSY
KDIESLMSEG NKSRTVAATN MNEESSRSHA VFKITLTHTL YDVKSGTSGE KVGKLSLVDL
AGSERATKTG AAGDRLKEGS NINKSLTTLG LVISALADQS AGKNKNKFVP YRDSVLTWLL
KDSLGGNSKT AMVATVSPAA DNYDETLSTL RYADRAKHIV NHAVVNEDPN ARIIRDLREE
VEKLREQLTQ AEAMKSPELK DRLEESEKLI QEMTVTWEEK LRKTEEIAQE RQKQLESLGI
SLQSSGIKVG DDKCFLVNLN ADPALNELLV YYLKEHTLIG SANSQDIQLC GMGILPEHCI
IDITSEGQVM LTPQKNTRTF VNGSSVSSPI QLHHGDRILW GNNHFFRLNL PKKKKKAERE
DEDQDHSMKN ENSSEQLDVD GDSSSEVSSE INFNYEYAQM EVTMKALGSN DPMQSILNSL
EQQHEEEKRS ALERQRLMYE HELEQLRRRL SPEKQNCRSM DRFSFHSPSA QQRLRQWAEE
REATLNNSLM RLREQIVKAN LLVREANYIA EELDKRTEYK VTLQIPASSL DANRKRGSLL
SEPAIQVRRK GKGKQIWSLE KLDNRLLDMR DLYQEWKECE EDNPVIRSYF KRADPFYDEQ
ENHSLIGVAN VFLESLFYDV KLQYAVPIIN QKGEVAGRLH VEVMRLSGDV GERIAGGDEV
AEVSFEKETQ ENKLVCMVKI LQATGLPQHL SHFVFCKYSF WDQQEPVIVA PEVDTSSSSV
SKEPHCMVVF DHCNEFSVNI TEDFIEHLSE GALAIEVYGH KINDPRKNPA LWDLGIIQAK
TRSLRDRWSE VTRKLEFWVQ ILEQNENGEY CPVEVISAKD VPTGGIFQLR QGQSRRVQVE
VKSVQESGTL PLMEECILSV GIGCVKVRPL RAPRTHETFH EEEEDMDSYQ DRDLERLRRK
WLNALTKRQE YLDQQLQKLV SKRDKTEDDA DREAQLLEMR LTLTEERNAV MVPSAGSGIP
GAPAEWTPVP GMETHIPVIF LDLNADDFSS QDNLDDPEAG GWDATLTGEE EEEFFELQIV
KQHDGEVKAE ASWDSAVHGC PQLSRGTPAD ERLFLIVRVT VQLSHPADMQ LVLRKRICVN
VHGRQGFAQS LLKKMSHRSS IPGCGVTFEI VSNIPEDAQG VEEREALARM AANVENPASA
DSEAYIEKYL RSVLAVENLL TLDRLRQEVA VKEQLTGKGK LSRRSISSPN VNRVSVWNQA
LCCGRWESQQ DVSQTTVSRG IAPAPALSVS PQNNHSPDPG LSNLAASYLN PVKSFVPQMP
KLLKSLFPVR DEKRGKRPSP LAHQPVPCIM VQSASPDIRV TRMEEVSLPC FPMGPDVLVQ
TMGAPALKIC DKPAKVPSPP PVIAVTAVTP APEAQDGPPS PLSEASSGYF SHSVSTATLS
DALGPGLDAA APPGSMPTAP EAEPEAPISH PPPPTAVPAE EPPGPQQLVS PGRERPDLKA
PAPGSPFRVR RVRASELRSF SRMLAGDPGC SPGAEGNAPA PGAGGQALAS DSEEADEVPE
WLREGEFVTV GAHKTGVVRY VGPADFQEGM WVGVELDLPS GKNDGSIGGK QYFRCNPGYG
LLVRPSRVRR ATGPVRRRST GLRLGAPEAR RSATLSGSAT NLASLTAALA KADRSHKNPE
NRKSWAS
//
