ID A0A2I3TAB7_PANTR Unreviewed; 774 AA.
AC A0A2I3TAB7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase {ECO:0000313|Ensembl:ENSPTRP00000085809.1};
GN Name=H6PD {ECO:0000313|Ensembl:ENSPTRP00000085809.1,
GN ECO:0000313|VGNC:VGNC:9873};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000085809.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000085809.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000085809.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway.
CC {ECO:0000256|ARBA:ARBA00004959}.
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DR EMBL; AC193211; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3TAB7; -.
DR Ensembl; ENSPTRT00000082102.1; ENSPTRP00000085809.1; ENSPTRG00000000113.6.
DR VGNC; VGNC:9873; H6PD.
DR GeneTree; ENSGT00530000063435; -.
DR UniPathway; UPA00115; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000000113; Expressed in liver and 21 other cell types or tissues.
DR GO; GO:0017057; F:6-phosphogluconolactonase activity; IEA:InterPro.
DR GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR CDD; cd01400; 6PGL; 1.
DR Gene3D; 3.40.50.1360; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR InterPro; IPR001282; G6P_DH.
DR InterPro; IPR019796; G6P_DH_AS.
DR InterPro; IPR022675; G6P_DH_C.
DR InterPro; IPR022674; G6P_DH_NAD-bd.
DR InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR NCBIfam; TIGR01198; pgl; 1.
DR PANTHER; PTHR23429:SF7; GDH_6PGL ENDOPLASMIC BIFUNCTIONAL PROTEIN; 1.
DR PANTHER; PTHR23429; GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD; 1.
DR Pfam; PF02781; G6PD_C; 1.
DR Pfam; PF00479; G6PD_N; 1.
DR Pfam; PF01182; Glucosamine_iso; 1.
DR PRINTS; PR00079; G6PDHDRGNASE.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
DR PROSITE; PS00069; G6P_DEHYDROGENASE; 1.
PE 4: Predicted;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Glucose metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..774
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014142219"
FT DOMAIN 29..210
FT /note="Glucose-6-phosphate dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF00479"
FT DOMAIN 232..490
FT /note="Glucose-6-phosphate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02781"
FT DOMAIN 543..765
FT /note="Glucosamine/galactosamine-6-phosphate isomerase"
FT /evidence="ECO:0000259|Pfam:PF01182"
FT BINDING 208
FT /ligand="substrate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10005"
SQ SEQUENCE 774 AA; 86770 MW; 85D2DDC6DE24CF31 CRC64;
MWNMLIVAMC LAFLGCLQAQ ELQGHVSIIL LGATGDLAKK YLWQGLFQLY LDEAGRGHSF
SFHGAALTAP RQGQELMAKA LESLSCPKDM APSHCAEHKD QFLQLSQYRQ LKTAEDYQAL
NKDIEAQLQH TGLREAGRIF YFSVPPFAYE DIARNINSSC RPGPGAWLRV VLEKPFGHDH
FSARQLATEL GTFFQEEEMY RVDHYLGKQV SINPSNKAAR SLWTPMVSLK VGRTGFYEEY
GVIRDVLQNH LTEVLTLVAM ELPHNVSSAE AVLRHKLQVF QALRGLQRGS AIVGQYQSYS
EQVRRELQKP DSFHSLTPTF AAVLVHIDNL RWEGVPFILM SGKALDERVG YARILFKNQA
CCVQSEKHWA AAQSQCLPRQ LVFHIGHGDL GSPAVLVSRN LFRPSLPSSW KEMEGPPGLR
LFGSPLSDYY AYSPVQERDA HSVLLSHIFH GRKDFFITTE NLLASWDFWT PLLESLAHKA
PRLYPGGAEN GRLLDFEFSS GRLFFSQQQP EQLVPGPGPA PMPSDFQVLR AKYRESPLVS
AWSEELISKL ANDIEATAVR AVRRFGQFHL ALSGGSSPVA LFQQLATAHY GFPWAHTHLW
LVDERCVPLS DPESNFQGLQ AHLLQHVRIP YYNIHPMPVH LQQRLCAEED QGAQIYAREI
SALVANSSFD LVLLGMGADG HTASLFPQSP TGLDGEQLVV LTTSPSQPHR RMSLSLPLIN
RAKKVAVLVM GRMKREITTL VSRVGHEPKK WPISGVLPHS GQLVWYMDYD AFLG
//
