ID A0A2I3TB12_PANTR Unreviewed; 691 AA.
AC A0A2I3TB12;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=TNF receptor associated protein 1 {ECO:0000313|Ensembl:ENSPTRP00000086059.1};
GN Name=TRAP1 {ECO:0000313|Ensembl:ENSPTRP00000086059.1,
GN ECO:0000313|VGNC:VGNC:9198};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000086059.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000086059.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000086059.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC {ECO:0000256|ARBA:ARBA00008239}.
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DR EMBL; AACZ04032131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04032132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04032133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3TB12; -.
DR Ensembl; ENSPTRT00000082357.1; ENSPTRP00000086059.1; ENSPTRG00000007708.4.
DR VGNC; VGNC:9198; TRAP1.
DR GeneTree; ENSGT01020000230401; -.
DR Proteomes; UP000002277; Chromosome 16.
DR Bgee; ENSPTRG00000007708; Expressed in hindlimb stylopod muscle and 21 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR CDD; cd16927; HATPase_Hsp90-like; 1.
DR Gene3D; 3.30.230.80; -; 1.
DR Gene3D; 3.40.50.11260; -; 1.
DR Gene3D; 1.20.120.790; Heat shock protein 90, C-terminal domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR HAMAP; MF_00505; HSP90; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR037196; HSP90_C.
DR InterPro; IPR001404; Hsp90_fam.
DR InterPro; IPR020575; Hsp90_N.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR PANTHER; PTHR11528:SF44; HEAT SHOCK PROTEIN 75 KDA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11528; HEAT SHOCK PROTEIN 90 FAMILY MEMBER; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF00183; HSP90; 1.
DR PIRSF; PIRSF002583; Hsp90; 1.
DR PRINTS; PR00775; HEATSHOCK90.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF110942; HSP90 C-terminal domain; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 93..246
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|SMART:SM00387"
SQ SEQUENCE 691 AA; 78708 MW; 29EA8675F8634873 CRC64;
WWQAPVVPAT REAEAGEWRE PGRQTEIVPL YSSLGDRARL CLKKKKSLKL INLSKLNFVG
CVCVSLLGST SKHEFQAETK KLLDIVARSL YSEKEVFIRE LISNASDALE KLRHKLVSDG
QALPEMEIHL QTNAEKGTIT IQDTGIGMTQ EELVSNLGTI ARSGSKAFLD ALQNQAEASS
KIIGQFGVGF YSAFMVADRV EVYSRSAAPG SPGYQWLSDG SGVFEIAEAS GVRTGTKIII
HLKSDCKEFS SEARVRDVVT KYSNFISFPL YLNGRRMNTL QAIWMMDPKD VGEWQHEEFY
RYVAQAHDKP RYILHYKTDA PLNIRSIFYV PDMVRPTALR VTLRELGSSV ALYSRKVLIQ
TKATDILPKW LRFIRGVVDS EDIPLNLSRE LLQESALIRK LRDVLQQRLI KYFIDQSKKD
AEKYAKFFED YGLFMREGIV TATEQEVKED IAKLLRYESS ALPSGQLTSL SEYASRMRAG
TRNIYYLCAP NRHLAEHSPY YEAMKKKDTE VLFCFEQFDE LTLLHLREFD KKKLISVETD
IVVDHYKEEK FEDRSPAAEC LSEKETEELL AWMRNVLGSR VTNVKVTLRL DTHPAMVTVL
EMGAARHFLR MQQLAKTQEE RAQLLQPTLE INPRHALIKK LNQLRASEPG LAQLLVDQIY
ENAMIAAGLV DDPRAMVGRL NELLVKALER H
//
