ID A0A2I3TBF1_PANTR Unreviewed; 279 AA.
AC A0A2I3TBF1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Trans-2,3-enoyl-CoA reductase {ECO:0000313|Ensembl:ENSPTRP00000086199.1};
GN Name=TECR {ECO:0000313|Ensembl:ENSPTRP00000086199.1,
GN ECO:0000313|VGNC:VGNC:1869};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000086199.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000086199.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000086199.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the steroid 5-alpha reductase family.
CC {ECO:0000256|ARBA:ARBA00007742}.
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DR EMBL; AACZ04031490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3TBF1; -.
DR Ensembl; ENSPTRT00000100885.1; ENSPTRP00000086199.1; ENSPTRG00000010595.6.
DR VGNC; VGNC:1869; TECR.
DR GeneTree; ENSGT00950000182886; -.
DR OMA; WAWKKEK; -.
DR Proteomes; UP000002277; Chromosome 19.
DR Bgee; ENSPTRG00000010595; Expressed in cerebellar cortex and 21 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 1.20.120.1630; -; 1.
DR InterPro; IPR001104; 3-oxo-5_a-steroid_4-DH_C.
DR InterPro; IPR039357; SRD5A/TECR.
DR InterPro; IPR049127; TECR-like_N.
DR PANTHER; PTHR10556; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; 1.
DR PANTHER; PTHR10556:SF31; VERY-LONG-CHAIN ENOYL-COA REDUCTASE; 1.
DR Pfam; PF02544; Steroid_dh; 1.
DR Pfam; PF21696; TECR_N; 1.
DR PROSITE; PS50244; S5A_REDUCTASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 56..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 168..254
FT /note="Steroid 5-alpha reductase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50244"
SQ SEQUENCE 279 AA; 32515 MW; 53EF88AD12FF7989 CRC64;
MSHRVEILDA KTREKLCFLD KVELGQGKSL KDEDVLQKLP VGTTATLYFR DLGAQISWVT
VFLTEYAGPL FIYLLFYFRV PFIYGHKYDF TSSRHTVVHL ACICHSFHYI KRLLETLFVH
RFSHGTMPLR NIFKNCTYYW GFAAWMAYYI NHPLYTPPTY GAQQVKLALA IFVICQLGNF
SIHMALRDLR PAGSKTRKIP YPTKNPFTWL FLLVSCPNYT YEVGSWIGFA IMTQCLPVAL
FSLVGFTQMT IWAKGKHRSY LKEFRDYPPL RMPIIPFLL
//
