ID A0A2I3TBI0_PANTR Unreviewed; 859 AA.
AC A0A2I3TBI0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Ral guanine nucleotide dissociation stimulator {ECO:0000313|Ensembl:ENSPTRP00000086579.1};
GN Name=RALGDS {ECO:0000313|Ensembl:ENSPTRP00000086579.1,
GN ECO:0000313|VGNC:VGNC:9195};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000086579.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000086579.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000086579.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04069155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04069156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3TBI0; -.
DR Ensembl; ENSPTRT00000094713.1; ENSPTRP00000086579.1; ENSPTRG00000021509.5.
DR VGNC; VGNC:9195; RALGDS.
DR GeneTree; ENSGT00940000153181; -.
DR Proteomes; UP000002277; Chromosome 9.
DR Bgee; ENSPTRG00000021509; Expressed in cerebellar cortex and 21 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd17209; RA_RalGDS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR015758; RalGDS_RA.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF35; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 57..194
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 331..593
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 743..830
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 225..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 611..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 673..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..251
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..309
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 859 AA; 94672 MW; 22C10E63B3ACDAA8 CRC64;
WGIDCASSTQ EIGEELINGV IYSISLRKVQ LHHGGNKGQR WLGYENESAL NLYETCKVRT
VKAGTLEKLV EHLVPAFQGS DLSYVTIFLC TYRAFTTTQQ VLDLLFKRYG RCDALTASSR
YGCILPYSDE DGGPQDQLKN AISSILGTWL DQYSEDFCQP PDFPCLKQLV AYVQLNMPGS
DLERRAHLLL AQLEHSEPIE AEPEALSPVP ALKPTPELEL ALTPARAPSP VPAPAPEPEP
APTPAPGSEL EVAPAPTPEL QQAPEPAVGL ESAPAPAPEL EPAPEQDPAP SQTLELEPAP
APVPSLQPSW PSPVVAENGL SEEKPHLLVF PPDLVAEQFT LMDAELFKKV VPYHCLGSIW
SQRDKKGKEH LAPTIRATVT QFNSVANCVI TTCLGNRSTK APDRARVVEH WIEVARECRI
LKNFSSLYAI LSALQSNSIH RLKKTWEDVS RDSFRIFQKL SEIFSDENNY SLSRELLIKE
GTSKFATLEM NPKRAQKRPK ETGIIQGTVP YLGTFLTDLV MLDTAMKDYL YGRLINFEKR
RKEFEVIAQI KLLQSACNNY SITPDEQFGA WFRAVERLSE TESYNLSCEL EPPSESASNT
LRTKKNTAIV KRWSDRQAPS TELSTSGSSH SKSCDQLRCG PYLSSGDIAD ALSVHSAGSS
SSDVEEINIS FVPESPDGQE KKFWESASQS SPETSGISSA SSSTSSSSAS TTPVAATRTH
KRSVSGLCNS SSALPLYNQQ VGDCCIIRVS LDVDNGNMYK SILVTSQDKA PAVIRKAMDK
HNLEEEEPED YELLQILSDD RKLKIPENAN VFYAMNSTAN YDFVLKKRTF TKGVKVKHGA
SSTLPRMKQK GLKIAKGIF
//
