ID A0A2I3TET3_PANTR Unreviewed; 1600 AA.
AC A0A2I3TET3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=IQ motif containing GTPase activating protein 2 {ECO:0000313|Ensembl:ENSPTRP00000087767.1};
GN Name=IQGAP2 {ECO:0000313|Ensembl:ENSPTRP00000087767.1,
GN ECO:0000313|VGNC:VGNC:4048};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000087767.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000087767.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000087767.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04061838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04061839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04061840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPTRT00000099789.1; ENSPTRP00000087767.1; ENSPTRG00000017002.7.
DR VGNC; VGNC:4048; IQGAP2.
DR GeneTree; ENSGT00950000183076; -.
DR InParanoid; A0A2I3TET3; -.
DR Proteomes; UP000002277; Chromosome 5.
DR Bgee; ENSPTRG00000017002; Expressed in bone marrow and 20 other cell types or tissues.
DR GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0030175; C:filopodium; IEA:Ensembl.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0071933; F:Arp2/3 complex binding; IEA:Ensembl.
DR GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:Ensembl.
DR GO; GO:1903479; P:mitotic actomyosin contractile ring assembly actin filament organization; IBA:GO_Central.
DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0070493; P:thrombin-activated receptor signaling pathway; IEA:Ensembl.
DR CDD; cd05131; RasGAP_IQGAP2; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001202; WW_dom.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR PANTHER; PTHR14149:SF12; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP2; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 15..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 66..181
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 619..652
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 942..1175
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT COILED 190..217
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1436..1463
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1600 AA; 183297 MW; 66BC55D8511A7FEF CRC64;
MWLTPGAEPS LQPSASPWLV ISCLFFFSFF LFETESRSVA QAGVQWRDLC SLQAPPPGKL
PNWNHFNIFF NLFRWMEVCL VEELPPTTEL EEGLRNGVYL AKLAKFFAPK MVSEKKIYDV
EQTRYKKSGL HFRHTDNTVQ WLRAMESIGL PKIFYPETTD VYDRKNIPRM IYCIHALSLY
LFKLGIAPQI QDLLGKVDFT EEEISNMRKE LEKYGIQMPS FSKIGGILAN ELSVDEAALH
AAVIAINEAV EKGIAEQTVV TLRNPNAVLT LVDDNLAPEY QKELWDAKKK KEENARLKNS
CISEEERDAY EELLTQAEIQ GNINKVNRQA AVDHINAVIP EGDPENTLLA LKKQEAQLPA
VYPFAAAMYQ NELFNLQKQN TMNYLAHEEL LIAVEMLSAV ALLNQALESN DLVSVQNQLR
SPAIGLNNLD KAYVERYANT LLSVKLEVLS QGQDNLSWNE IQNCIDMVNA QIQEENDRVV
AVGYINEAID EGNPLRTLET LLLPTANISD VDPAHAQHYQ DVLYHAKSQK LRDSESVSKV
LWLDEIQQAV DEANVDEDRA KQWVTLVVDV NQCLEGKKSS DILSVLKSST SNANDIIPEC
ADKYYDALVK AKELKSERVS SDGSWLKLNL HEKYDYYYNI DSKESSWVTP ESCLYKESWL
TGKEIEDIIE EVTVGYIREN IWSASEELLL RFQATSSGPI LREEFEARKS FLHEQEENVV
KIQAFWKGYK QRKEYMHRRQ TFIDNTDSIV KIQSWFRMAT ARKSYLSRLQ YFRDHNNEIV
KIQSLLRANK ARDDYKTLVG SENPPLTVIR KFVYLLDQSD LDFQEELEVA RLREEVVTKI
RANQQLEKDL NLMDIKIGLL VKNRITLEDV ISHSKKLNKK KGGEMEILNN TDNQGIKSLS
KERRKTLETY QQLFYLLQTN PLYLAKLIFQ MPQNKSTKFM DTVIFTLYNY ASNQREEYLL
LKLFKTALEE EIKSKVDQVQ DIVTGNPTVI KMVVSFNRGA RGQNTLRQLL APVVKEIIDD
KSLIINTNPV EVYKAWVNQL ETQTGEASKL PYDVTTEQAL TYPEVKNKLE ASIENLRRVT
DKVLNSIISS LDLLPYGLRY IAKVLKNSIH EKFPDATEDE LLKIVGNLLY YRYMNPAIVA
PDGFDIIDMT AGGQINSDQR RNLGSVAKVL QHAASNKLFE GENEHLSSMN NYLSETYQEF
RKYFKEACNV PEPEEKFNMD KYTDLVTVSK PVIYISIEEI ISTHSLLLEH QDAIAPEKND
LLSELLGSLG EVPTVESFLG EGAVDPNDPN KANTLSQLSK TEISLVLTSK YDIEDGEAID
SRSLMIKTKK LIIDVIRNQP GNTLTEILET PATAQQEVDH ATDMVSRAMI DSRTPEEMKH
SQSMIEDAQL PLEQKKRKIQ RNLRTLEQTG HVSSENKYQD ILNEIAKDIR NQRIYRKLRK
AELAKLQQTL NALNKKAAFY EEQINYYDTY IKTCLDNLKR KNTRRSIKLD GKGEPKGAKR
AKPVKYTAAK LHEKGVLLDI DDLQTNQFKN VTFDIIATED VGIFDVRSKF LGVEMEKVQL
NIQDLLQMQY EGVAVMKMFD KVKVNVNLLI YLLNKKFYGK
//
