ID A0A2I3TIG7_PANTR Unreviewed; 2158 AA.
AC A0A2I3TIG7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRQ {ECO:0000313|Ensembl:ENSPTRP00000089019.1,
GN ECO:0000313|VGNC:VGNC:8506};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000089019.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000089019.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000089019.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR EMBL; AACZ04071913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04071914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04071915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPTRT00000102511.1; ENSPTRP00000089019.1; ENSPTRG00000039205.2.
DR VGNC; VGNC:8506; PTPRQ.
DR GeneTree; ENSGT00940000159215; -.
DR InParanoid; A0A2I3TIG7; -.
DR OMA; KRTMAGN; -.
DR Proteomes; UP000002277; Chromosome 12.
DR Bgee; ENSPTRG00000039205; Expressed in lung and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0032421; C:stereocilium bundle; IEA:Ensembl.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IEA:Ensembl.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
DR GO; GO:0060116; P:vestibular receptor cell morphogenesis; IEA:Ensembl.
DR CDD; cd00063; FN3; 16.
DR CDD; cd14616; R-PTPc-Q; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 16.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF1; PHOSPHATIDYLINOSITOL PHOSPHATASE PTPRQ; 1.
DR Pfam; PF00041; fn3; 14.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 16.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 9.
DR PROSITE; PS50853; FN3; 14.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1774..1796
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..99
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 176..264
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 436..531
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 536..625
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 630..720
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 725..814
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 819..919
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 924..1016
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1018..1108
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1113..1206
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1210..1296
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1300..1404
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1409..1507
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1512..1613
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1862..2118
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 2038..2109
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 2158 AA; 241806 MW; 9EC1486B6E9EA606 CRC64;
MKKVPIKPEQ PEKLRAFNIS THSFSLHWSL PSGHVERYQV DLVPDSGFVT IRDLGGGEYQ
VDVSNVVPGT RYDITISSIS TTYSSPVTRI VTTNATKPGP PVFLAGERVG SAGILLSWNT
PPNPNGRIIS YIVKYKEVCP WMQTVYTQVR AKPDSLEVLL TNLNPGTTYE IKPEGPPQNC
VTGNITGKSF SILWDPPTIV TGKFSYRVEL YGPSGRILDN STKELKFAFT NLTPFTMYDV
YIAAETSAGT GPKSNISVFT PPDVPGAVFD LQLAEVESTQ VRITWKKPRQ PNGIINQYRV
KVLVPETGII LENTLLTGNN EYINDPMAPE IVNIVEPMVG LYEGSAEMSS DLHSLATFIY
NSHPDKNFPA RNRAEDQTSP VVTTRNQYIT DIAAEQLSYV IRRLVPFTEH MIGVSAFTIM
GEGPPTVLSV RTHQQVPSSI KIINYKNISS SSILLYWDPP EYPNGKITHY TIYAMELDTN
RAFQITTIDN SFLITGLKKY AKYKMRVAAS THVGESSLSE ENDIFVRTSE DEPESSPQDV
EVIDVTADEI RLKWSPPEKP NGIIIAYEVL YKNIDTLYMK NTSTTDIILR NLRPHTLYNI
SVRSYTRFGH GNQVSSLLSV RTSETVPDSA PENITYKNIS SGEIELSFLP PSSPNGIIQK
YTIYLKRSNG NEERTINTTS LTQNIKGLKK YTQYIIEVSA STLKGEGVRS APISILTEED
APDSPPQDFS VKQLSGVTVK LSWQPPLEPN GIILYYTVYV WNRSSLKTIN VTETSLALSD
LDYNVEYTAY VTASTRFGDG KTRSNIISFQ TPEGAPSDPP KDVYYANLSS SSIILFWTPP
SKPNGIIQYY SVYYRNTSGT FMQNFTLHEV TNDFDSMTVS TIIDKLTIFS YYTFWLTAST
SVGNGNKSSD IIEVYTDQDI PEGLVGNLTY ESISSTAINV SWVPPAQPNG LVFYYVSLIL
QQTPRHVRPP LVTYERSIYF DNLEKYTDYI LKITPSTEKG FSDTYTAQLY IKTEEDVPET
SPIINTFKNL SSTSVLLSWD PPVKPNGAII SYDLTLQGPN ENYSFITSDN YIILEELSPF
TLYSFFAAAR TRKGLGPSSI LFFYTDESVP LAPPQNLTLI NCTSDFVWLK WSPSPLPGGI
VKVYSFKIHE HETDTIYYKN ISGFKTEAKL VGLEPVSTYS IRVSAFTKVG NGNQFSNVVK
FTTQESVPDV VQNMQCMATS WQSVLVKWDP PKKANGIITQ YMITVERNST KVSPQDHMYT
FIKLLANTSY VFKVRASTSA GEGDESTCHV STLPETVPSV PTNIAFSDVQ STSATLTWIR
PDTILGYFQN YKITTQLRAQ KCKEWESEEC VEYQKIQYLY EAHLTEETVY GLKKFRWYRF
QVAASTNAGY GNASNWISTQ TLPGPPDGPP ENVHVVATSP FSISISWSEP AVITGPTCYL
IDVKSVDNDE FNISFIKSNE ENKTIEIKDL EIFTRYSVVI TAFTGNISAA YVEGKSSAEM
IVTTLESAPK DPPNNMTFQK IPDEVTKFQL TFLPPSQPNG NIQVYQALVY REDDPTAVQI
HNLSIIQKTN TFVIAVLEGL KGGHTYNISV YAVNSAGAGP KVPMRITMDI KAPARPKTKP
TPIYDATGKL LVTSTTITIR MPICYYSDDH GPIKNVQVLV TETGAQHDGN VTKWYDAYFN
KARPYFTNEG FPNPPCTEEK TKFSGNEEIY IIGADNACMI PGNEDKICNG PLKPKKQYLF
KFRATNIMGQ FTDSDYSDPV KTLGEGLSER TVEIILSVTL CILSIILLGT AIFAFARIRQ
KQKEGGTYSP QDAEIIDTKL KLDQLITVAD LELKDERLTR PISKKSFLQH VEELCTNNNL
KFQEEFSELP KFLQDLSSTD ADLPWNRAKN RFPNIKPYNN NRVKLIADAS VPGSDYINAS
YISGYLCPNE FIATQGPLPG TVGDFWRMVW ETRAKTLVML TQCFEKGRIR CHQYWPEDNK
PVTVFGDIVI TKLMEDVQID WTIRDLKIER HGDCMTVRQC NFTAWPEHGV PENSAPLIHF
VKLVRASRAH DTTPMIVHCS AGVGRTGVFI ALDHLTQHIN DHDFVDIYGL VAELRSERMC
MVQNLAQYIF LHQCILDLLS NKGSNQPICF VNYSALQKMD SLDAMEGDVE LEWEETTM
//
