ID A0A2I3TIR5_PANTR Unreviewed; 1477 AA.
AC A0A2I3TIR5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Adhesion G protein-coupled receptor L1 {ECO:0000313|Ensembl:ENSPTRP00000089146.1};
GN Name=ADGRL1 {ECO:0000313|Ensembl:ENSPTRP00000089146.1,
GN ECO:0000313|VGNC:VGNC:6609};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000089146.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000089146.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000089146.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AACZ04031471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPTRT00000080887.1; ENSPTRP00000089146.1; ENSPTRG00000010588.6.
DR VGNC; VGNC:6609; ADGRL1.
DR GeneTree; ENSGT00940000159684; -.
DR InParanoid; A0A2I3TIR5; -.
DR Proteomes; UP000002277; Chromosome 19.
DR Bgee; ENSPTRG00000010588; Expressed in dorsolateral prefrontal cortex and 19 other cell types or tissues.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0042734; C:presynaptic membrane; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0016524; F:latrotoxin receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR CDD; cd16007; 7tmB2_Latrophilin-1; 1.
DR CDD; cd22844; Gal_Rha_Lectin_LPHN1; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR003924; GPCR_2_latrophilin.
DR InterPro; IPR003334; GPCR_2_latrophilin_rcpt_C.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR031234; Latrophilin-1_TM.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR InterPro; IPR003112; Olfac-like_dom.
DR PANTHER; PTHR12011:SF62; ADHESION G PROTEIN-COUPLED RECEPTOR L1; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF02140; Gal_Lectin; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF02354; Latrophilin; 1.
DR Pfam; PF02191; OLF; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01444; LATROPHILIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00284; OLF; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51132; OLF; 1.
DR PROSITE; PS50228; SUEL_LECTIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00446};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 850..877
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 889..906
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 921..945
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 957..976
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 996..1019
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1040..1063
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1069..1092
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..119
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DOMAIN 131..390
FT /note="Olfactomedin-like"
FT /evidence="ECO:0000259|PROSITE:PS51132"
FT DOMAIN 469..528
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 852..1093
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 392..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1153..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1251..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1297..1331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1363..1432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1454..1477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1304..1318
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1363..1381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1407..1427
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 132..314
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00446"
SQ SEQUENCE 1477 AA; 162882 MW; 553D01EDBD680999 CRC64;
TTGVLTPSPT LPAGLSRAGL PFGLMRRELA CEGYPIELRC PGSDVIMVEN ANYGRTDDKI
CDADPFQMEN VQCYLPDAFK IMSQRCNNRT QCVVVAGSDA FPDPCPGTYK YLEVQYDCVP
YKVEQKGKLF VCPGTLQKVL EPTSTHESEH QSGAWCKDPL QAGDRIYVMP WIPYRTDTLT
EYASWEDYVA ARHTTTYRLP NRVDGTGFVV YDGAVFYNKE RTRNIVKYDL RTRIKSGETV
INTANYHDTS PYRWGGKTDI DLAVDENGLW VIYATEGNNG RLVVSQLNPY TLRFEGTWET
GYDKRSASNA FMVCGVLYVL RSVYVDDDSE AAGNRVDYAF NTNANREEPV SLTFPNPYQF
ISSVDYNPRD NQLYVWNNYF VVRYSLEFGP PDPSAGPATS PPLSTTTTAR PTPLTSTASP
AATTPLRRAP LTTHPVGAIN QLGPDLPPAT APVPSTRRPP APNLHVSPEL FCEPREVRRV
QWPATQQGML VERPCPKGTR GIASFQCLPA LGLWNPRGPD LSNCTSPWVN QVAQKIKSGE
NAANIASELA RHTRGSIYAG DVSSSVKLME QLLDILDAQL QALRPIERES AGKNYNKMHK
RERTCKDYIK AVVETVDNLL RPEALESWKD MNATEQVHTA TMLLDVLEEG AFLLADNVRE
PARFLAAKEN VVLEVTVLNT EGQVQELVFP QEEYPRKNSI QLSAKTIKQN SRNGVVKVVF
ILYNNLGLFL STENATVKLA GEAGPGGPGG ASLVVNSQVI AASINKESSR VFLMDPVIFT
VAHLEDKNHF NANCSFWNYS ERSMLGYWST QGCRLVESNK THTTCACSHL TNFAVLMAHR
EIYQGRINEL LLSVITWVGI VISLVCLAIC ISTFCFLRGL QTDRNTIHKN LCINLFLAEL
LFLVGIDKTQ YEIACPIFAG LLHYFFLAAF SWLCLEGVHL YLLLVEVFES EYSRTKYYYL
GGYCFPALVV GIAAAIDYRS YGTEKACWLR VDNYFIWSFI GPVSFVIVVN LVFLMVTLHK
MIRSSSVLKP DSSRLDNIKS WALGAIALLF LLGLTWAFGL LFINKESVVM AYLFTTFNAF
QGVFIFVFHC ALQKKVHKEY SKCLRHSYCC IRSPPGGTHG SLKTSAMRSN TRYYTGTQPE
RWGVAWPRRQ RVGGPRIPSH LGNRRSPPSW RVTSTVRRHP SASGFSTMGN HLLTNPVLQP
RGGTSPYNTL IAESVGFNPS SPPVFNSPGE KHPLGGREAC GMDTLPLNGN FNNSYSLRSG
DFPPGDGGPE PPRGRNLADA AAFEKMIISE LVHNNLRGSS SAAKGPPPPE PPVPPVPGGG
GEEEAGGPGG ADRAEIELLY KALEEPLLLP RAQSVLYQSD LDESESCTAE DGATSRPLSS
PPGRDSLYAS GANLRDSPSY PDSSPEGPSE ALPPPPPAPP GPPEIYYTSR PPALVARNPL
QGYYQVRRPS HEGYLAAPGL EGPGPDGDGQ MQLVTSL
//
