ID A0A2I3TIR6_PANTR Unreviewed; 1183 AA.
AC A0A2I3TIR6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=PTPRF interacting protein alpha 4 {ECO:0000313|Ensembl:ENSPTRP00000089118.1};
GN Name=PPFIA4 {ECO:0000313|Ensembl:ENSPTRP00000089118.1,
GN ECO:0000313|VGNC:VGNC:57600};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000089118.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000089118.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000089118.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the liprin family. Liprin-alpha subfamily.
CC {ECO:0000256|ARBA:ARBA00007026}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04071416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3TIR6; -.
DR Ensembl; ENSPTRT00000091781.1; ENSPTRP00000089118.1; ENSPTRG00000050591.1.
DR VGNC; VGNC:57600; PPFIA4.
DR GeneTree; ENSGT01050000244900; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000050591; Expressed in cerebellar cortex and 15 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR CDD; cd09562; SAM_liprin-alpha1_2_3_4_repeat1; 1.
DR CDD; cd09565; SAM_liprin-alpha1_2_3_4_repeat2; 1.
DR CDD; cd09568; SAM_liprin-alpha1_2_3_4_repeat3; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 3.
DR InterPro; IPR029515; Liprin.
DR InterPro; IPR037620; Liprin-alpha_SAM_rpt_1.
DR InterPro; IPR037621; Liprin-alpha_SAM_rpt_2.
DR InterPro; IPR037622; Liprin-alpha_SAM_rpt_3.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12587; LAR INTERACTING PROTEIN LIP -RELATED PROTEIN; 1.
DR PANTHER; PTHR12587:SF5; LIPRIN-ALPHA-4; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 3.
DR SUPFAM; SSF47769; SAM/Pointed domain; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 827..893
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 949..1006
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 1030..1099
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 636..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 30..121
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 165..192
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 228..416
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 449..497
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 636..653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..694
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 723..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1183 AA; 134092 MW; C3ACED51E45325E2 CRC64;
MCEVMPTINE GDPLGPPHGA DADANFEQLM VNMLDEREKL LESLRESQET LAATQSRLQD
ALHERDQLQR HLNSALPQEF ATLTRELSMC REQLLEREEE ISELKAERNN TRLLLEHLEC
LVSRHERSLR MTVVKRQAQS PSGVSSEVEV LKALKSLFEH HKALDEKVRE RLRAALERVT
TLEEQLAGAH QQVSALQQGA GVRDGAAEEE GTVELGPKRL WKEDTGRVEE LQELLEKQNF
ELSQARERLV TLTTTVTELE EDLGTARRDL IKSEELSSKH QRDLREALAQ KEDMEERITT
LEKRYLAAQR EATSIHDLND KLENELANKE SLHRQCEEKA RHLQELLEVA EQKLQQTMRK
AETLPEVEAE LAQRIAALTK AEERHGNIEE HLRQLEGQLE EKNQELARTA VQVRQREKMN
EDHNKRLSDT VDRLLSESNE RLQLHLKERM AALEEKNTLI QELESSQRQI EEQHHHKGRL
SEEIEKLRQE VDQLKGRGGP FVDGVHSRSH MGSAADVRFS LGTTTHAPPG VHRRYSALRE
ESAKLPLPLT VTLTSPTWMR MSQGVCCNLE YHSSGTLCGS SGPLAQMIQE EKESTELRAE
EIETRVTSGS MEALNLKQLR KRGSIPTSLT ALSLASASPP LSGRSTPKLT SRSAAQDLDR
MGVMTLPSDL RKHRRKLLSP VSREENREDK ATIKCETSPP SSPRTLRLEK LGHPALSQEE
GKSALEDQGS NPSSSNSSQD SLHKGAKRKG IKSSIGRLFG KKEKGRLIQL SRDGATGHVL
LTDSEFSMQE PMVPAKLGTQ AEKDRRLKKK HQLLEDARRK GMPFAQWDGP TVVSWLELWV
GMPAWYVAAC RANVKSGAIM SALSDTEIQR EIGISNALHR LKLRLAIQEM VSLTSPSAPP
TSRTSSGNVW VTHEEMETLE TSTKTDSEEG SWAQTLAYGD MNHEWIGNEW LPSLGLPQYR
SYFMECLVDA RMLDHLTKKD LRVHLKMVDS FHRTSLQYGI MCLKRLNYDR KELEKRREES
QHEIKDVLVW TNDQVVHWVQ SIGLRDYAGN LHESGVHGAL LALDENFDHN TLALILQIPT
QNTQARQVME REFNNLLALG TDRKLDDGDD KVFRRAPSWR KRFRPREHHG RGGMLSASAE
TLPAGFRVST LGTLQPPPAP PKKIMPEAHS HYLYGHMLSA FRD
//
