ID A0A2I3TJ03_PANTR Unreviewed; 651 AA.
AC A0A2I3TJ03;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Proprotein convertase subtilisin/kexin type 6 {ECO:0000313|Ensembl:ENSPTRP00000088860.1};
GN Name=PCSK6 {ECO:0000313|Ensembl:ENSPTRP00000088860.1,
GN ECO:0000313|VGNC:VGNC:7527};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000088860.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000088860.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000088860.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240, ECO:0000256|RuleBase:RU003355}.
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DR EMBL; AACZ04059919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04059920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3TJ03; -.
DR Ensembl; ENSPTRT00000099608.1; ENSPTRP00000088860.1; ENSPTRG00000007514.6.
DR VGNC; VGNC:7527; PCSK6.
DR GeneTree; ENSGT00940000159506; -.
DR OMA; EYARNAY; -.
DR Proteomes; UP000002277; Chromosome 15.
DR Bgee; ENSPTRG00000007514; Expressed in spleen and 21 other cell types or tissues.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR PANTHER; PTHR42884:SF8; PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 6; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 494..651
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT ACT_SITE 204
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 245
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 419
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 651 AA; 71961 MW; D9733131692B8F37 CRC64;
SRRPARAAPG LRAAPLRTNL AGGVRSGVSV GAGGAGGPGF RPLAPRPWRW LLLLALPAAC
SAPPPRPVYT NHWAVQVLGG PAEADRVAAA HGYLNLGQIG NLEDYYHFYH SKTFKRSTLS
SRGPHTFLRM DPQVKWLQQQ EVKRRVKRQV RSDPQALYFN DPIWSNMWYL HCGDKNSHCR
SEMNVQAAWK RGYTGKNVVV TILDDGIERN HPDLAPNYDS YASYDVNGND YDPSPRYDAS
NENKHGTRCA GEVAASANNS YCIVGIAYNA KIGGIRMLDG DVTDVVEAKS LGIRPNYIDI
YSASWGPDDD GKTVDGPGRL AKQAFEYGIK KGRQGLGSIF VWASGNGGRE GDYCSCDGYT
NSIYTISVSS ATENGYKPWY LEECASTLAT TYSSGAFYER KIVTTDLRQR CTDGHTGTSV
SAPMVAGIIA LALEANSQLT WRDVQHLLVK TSRPAHLKAS DWKVNGAGHK VSHFYGFGLV
DAEALVVEAK KWTAVPSQHM CVAASDKRPR SIPLVQVLRT TALTSACAEH SDQRVVYLEH
VVVRTSISHP RRGDLQIYLV SPSGTKSQLL AKRLLDLSNE GFTNWEFMTV HCWGEKAEGQ
WTLEIQDLPS QVRNPEKQGD LETPVANQLT TEEREPGLKH VFRWQIEQEL W
//
