ID A0A2I3TJY2_PANTR Unreviewed; 604 AA.
AC A0A2I3TJY2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=procollagen galactosyltransferase {ECO:0000256|ARBA:ARBA00038926};
DE EC=2.4.1.50 {ECO:0000256|ARBA:ARBA00038926};
GN Name=COLGALT1 {ECO:0000313|Ensembl:ENSPTRP00000089531.1,
GN ECO:0000313|VGNC:VGNC:14840};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000089531.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000089531.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000089531.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose =
CC (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) +
CC UDP; Xref=Rhea:RHEA:12637, Rhea:RHEA-COMP:12752, Rhea:RHEA-
CC COMP:12753, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914,
CC ChEBI:CHEBI:133442, ChEBI:CHEBI:133443; EC=2.4.1.50;
CC Evidence={ECO:0000256|ARBA:ARBA00036299};
CC -!- SIMILARITY: Belongs to the glycosyltransferase 25 family.
CC {ECO:0000256|ARBA:ARBA00006721}.
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DR EMBL; AACZ04031531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04031532; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3TJY2; -.
DR Ensembl; ENSPTRT00000105217.1; ENSPTRP00000089531.1; ENSPTRG00000010680.6.
DR VGNC; VGNC:14840; COLGALT1.
DR GeneTree; ENSGT01030000234558; -.
DR Proteomes; UP000002277; Chromosome 19.
DR Bgee; ENSPTRG00000010680; Expressed in fibroblast and 21 other cell types or tissues.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd06532; Glyco_transf_25; 1.
DR InterPro; IPR002654; Glyco_trans_25.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR10730:SF28; PROCOLLAGEN GALACTOSYLTRANSFERASE 1; 1.
DR PANTHER; PTHR10730; PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER; 1.
DR Pfam; PF01755; Glyco_transf_25; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..36
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 37..604
FT /note="procollagen galactosyltransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014198039"
FT REGION 570..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..584
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 604 AA; 69107 MW; AB8F751D48C4F30A CRC64;
MAAAPRAGRR RGQSLLALLL LLLAPLPPGA PPGADAYFPE ERWSPESPLQ APRVLIALLA
RNAAHALPTT LGALERLRHP RERTALWVAT DHNMDNTSTV LREWLVAVKS LYHSVEWRPA
EEPRSLPDPQ GTGLSHADAL WGVLQFVDAD NLILNPDTLS LLIAENKTVV APMLDSRAAY
SNFWCGMTSQ GYYKRTPAYI PIRKRDRRGC FAVPMVHSTF LIDLRKAASR NLAFYPPHPD
YTWSFDDIIV FAFSCKQAEV QMYVCNKEEY GFLPVPLRAH STLQDEAESF MHVQLEVMVK
HPPAEPSRFI SAPTKTPDKM GFDEVFMINL RRRQDRRERM LRALQAQEIE CRLVEAVDGK
AMNTSQVEAL GIQMLPGYRD PYHGRPLTKG ELGCFLSHYN IWKEVVDRGL QKSLVFEDDL
RFEIFFKRRL MNLMRDVERE GLDWDLIYVG RKRMQVEHPE KAVPRVRNLV EADYSYWTLA
YVISLQGARK LLAAEPLSKM LPVDEFLPVM FDKHPVSEYK AHFSLRNLHA FSVEPLLIYP
THYTGDDGYV SDTETSVVWN NEHVKTDWDR AKSQKMREQQ ALSREAKNSD VLQSPLDSAA
RDEL
//
