ID A0A2I3TKD1_PANTR Unreviewed; 717 AA.
AC A0A2I3TKD1; A0A2J8QRP2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase {ECO:0000313|Ensembl:ENSPTRP00000089687.1};
GN Name=GNE {ECO:0000313|Ensembl:ENSPTRP00000089687.1,
GN ECO:0000313|VGNC:VGNC:8890};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000089687.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000089687.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000089687.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04033385; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003312123.1; XM_003312075.3.
DR AlphaFoldDB; A0A2I3TKD1; -.
DR Ensembl; ENSPTRT00000108279.1; ENSPTRP00000089687.1; ENSPTRG00000020931.6.
DR VGNC; VGNC:8890; GNE.
DR GeneTree; ENSGT00390000017246; -.
DR OrthoDB; 5489121at2759; -.
DR Proteomes; UP000002277; Chromosome 9.
DR Bgee; ENSPTRG00000020931; Expressed in liver and 21 other cell types or tissues.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0006047; P:UDP-N-acetylglucosamine metabolic process; IEA:InterPro.
DR CDD; cd03786; GTB_UDP-GlcNAc_2-Epimerase; 1.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000600; ROK.
DR InterPro; IPR020004; UDP-GlcNAc_Epase.
DR InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR NCBIfam; TIGR03568; NeuC_NnaA; 1.
DR PANTHER; PTHR18964:SF149; BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE_N-ACETYLMANNOSAMINE KINASE; 1.
DR PANTHER; PTHR18964; ROK (REPRESSOR, ORF, KINASE) FAMILY; 1.
DR Pfam; PF02350; Epimerase_2; 1.
DR Pfam; PF00480; ROK; 1.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 35..370
FT /note="UDP-N-acetylglucosamine 2-epimerase"
FT /evidence="ECO:0000259|Pfam:PF02350"
FT ACT_SITE 512
FT /evidence="ECO:0000256|PIRSR:PIRSR620004-1"
FT BINDING 472
FT /ligand="an N-acyl-D-mannosamine"
FT /ligand_id="ChEBI:CHEBI:16062"
FT /evidence="ECO:0000256|PIRSR:PIRSR620004-2"
FT BINDING 484
FT /ligand="an N-acyl-D-mannosamine"
FT /ligand_id="ChEBI:CHEBI:16062"
FT /evidence="ECO:0000256|PIRSR:PIRSR620004-2"
FT BINDING 512
FT /ligand="an N-acyl-D-mannosamine"
FT /ligand_id="ChEBI:CHEBI:16062"
FT /evidence="ECO:0000256|PIRSR:PIRSR620004-2"
FT BINDING 561
FT /ligand="an N-acyl-D-mannosamine"
FT /ligand_id="ChEBI:CHEBI:16062"
FT /evidence="ECO:0000256|PIRSR:PIRSR620004-2"
FT BINDING 564
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="structural"
FT /evidence="ECO:0000256|PIRSR:PIRSR620004-3"
FT BINDING 564
FT /ligand="an N-acyl-D-mannosamine"
FT /ligand_id="ChEBI:CHEBI:16062"
FT /evidence="ECO:0000256|PIRSR:PIRSR620004-2"
FT BINDING 574
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="structural"
FT /evidence="ECO:0000256|PIRSR:PIRSR620004-3"
FT BINDING 576
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="structural"
FT /evidence="ECO:0000256|PIRSR:PIRSR620004-3"
FT BINDING 581
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="structural"
FT /evidence="ECO:0000256|PIRSR:PIRSR620004-3"
FT BINDING 583
FT /ligand="an N-acyl-D-mannosamine"
FT /ligand_id="ChEBI:CHEBI:16062"
FT /evidence="ECO:0000256|PIRSR:PIRSR620004-2"
SQ SEQUENCE 717 AA; 78579 MW; 6CCF484FC092DAF4 CRC64;
MPIGDCSVAA KPRKQLLCSL FQTTLGYRAC ASGWKPMVIR RGSHAFKDLI NTYRMIEQDD
FDINTRLHTI VRGEDEAAMV ESVGLALVKL PDVLNRLKPD IMIVHGDRFD ALALATSAAL
MNIRILHIEG GEVSGTIDDS IRHAITKLAH YHVCCTRSAE QHLISMCEDH DRILLAGCPS
YDKLLSAKNK DYMSIIRMWL GDDVKSKDYI VALQHPVTTD IKHSIKMFEL TLDALISFNK
RTLVLFPNID AGSKEMVRVM RKKGIEHHPN FRAVKHVPFD QFIQLVAHAG CMIGNSSCGV
REVGAFGTPV INLGTRQIGR ETGENVLHVR DADTQDKILQ ALHLQFGKQY PCSKIYGDGN
AVPRILKFLK SIDLQEPLQK KFCFPPVKEN ISQDIDHILE TLSALAVDLG GTNLRVAIVS
MKGEIVKKYT QFNPKTYEER INLILQMCVE AAAEAVKLNC RILGVGISTG GRVNPREGIV
LHSTKLIQEW NSVDLRTPLS DTLHLPVWVD NDGNCAALAE RKFGQGKGLE NFVTLITGTG
IGGGIIHQHE LIHGSSFCAA ELGHLVVSLD GPDCSCGSHG CIEAYASGMA LQREAKKLHD
EDLLLVEGMS VPKDEAVGAL HLIQAAKLGN AKAQSILRTA GTALGLGVVN ILHTMNPSLV
ILSGVLASHY IHIVKDVIRQ QALSSVQDVD VVVSDLVDPA LLGAASMVLD YTTRRIY
//
