ID A0A2I3TMA2_PANTR Unreviewed; 550 AA.
AC A0A2I3TMA2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=AT-rich interactive domain-containing protein 3 {ECO:0000256|RuleBase:RU369100};
DE Short=ARID domain-containing protein {ECO:0000256|RuleBase:RU369100};
GN Name=ARID3B {ECO:0000313|Ensembl:ENSPTRP00000090367.1,
GN ECO:0000313|VGNC:VGNC:11777};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000090367.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000090367.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000090367.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transcription factor. {ECO:0000256|RuleBase:RU369100}.
CC -!- SUBUNIT: Heterodimer with ARID3A. Interacts with unphosphorylated RB1.
CC {ECO:0000256|RuleBase:RU369100}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369100}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04060363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3TMA2; -.
DR Ensembl; ENSPTRT00000107088.1; ENSPTRP00000090367.1; ENSPTRG00000007277.6.
DR VGNC; VGNC:11777; ARID3B.
DR GeneTree; ENSGT00940000156052; -.
DR Proteomes; UP000002277; Chromosome 15.
DR Bgee; ENSPTRG00000007277; Expressed in testis and 21 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.150.60; ARID DNA-binding domain; 1.
DR InterPro; IPR045147; ARI3A/B/C.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR InterPro; IPR023334; REKLES_domain.
DR PANTHER; PTHR15348:SF3; AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 3B; 1.
DR PANTHER; PTHR15348; AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN ARID DOMAIN- CONTAINING PROTEIN DEAD RINGER PROTEIN B-CELL REGULATOR OF IGH TRANSCRIPTION BRIGHT; 1.
DR Pfam; PF01388; ARID; 1.
DR SMART; SM01014; ARID; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SUPFAM; SSF46774; ARID-like; 1.
DR PROSITE; PS51011; ARID; 1.
DR PROSITE; PS51486; REKLES; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU369100};
KW Nucleus {ECO:0000256|RuleBase:RU369100};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transcription {ECO:0000256|RuleBase:RU369100};
KW Transcription regulation {ECO:0000256|RuleBase:RU369100}.
FT DOMAIN 206..298
FT /note="ARID"
FT /evidence="ECO:0000259|PROSITE:PS51011"
FT DOMAIN 408..506
FT /note="REKLES"
FT /evidence="ECO:0000259|PROSITE:PS51486"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..109
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 550 AA; 59088 MW; 4A38A076E9614051 CRC64;
PEPLCQQQQQ QQQQQKQPHL APLQMDAREK QGQQMREAQF LYAQKLVTQP TLLSATAGRP
SGSTPLGPLA RVPPTAAVAQ VFERGNMNSE PEEEDGGLED EDGDDEVAEV AEKETQAASK
YFHVQKVAHQ DPRVAPMSNL LPAPGLPPHG QQAKEDHTKD ASKASPSVST AGQPNWNLDE
QLKQNGGLAW SDDADGGRGR EISRDFAKPD DDPAVSFSHW TTTGTPINRI PIMAKQILDL
YMLYKLVTEK GGLVEIINKK IWREITKGLN LPTSITSAAF TLRTQYMKYL YAYECEKKAL
SSPAELQAAI DGNRREGRRP SYSSSLFGYS PAAATAAAGA PALLSPPKIR FPILGLGSSS
GTNTSSPRIS PATTLRKGDG APVTTVPVPN RLAVPVTLAS QQAGTRTAAL EQLRERLESG
EPAEKKASRL SEEEQRLVQQ AFQRNFFSMA RQLPMKIRIN GRAEDRAEAS AAALNLTTSS
IGSINMSVDI DGTTYAGVLF AQKPVVHLIT GSAPQSLGSS ASSSSSSHCS PSPTSSRGTP
SAEPSTSWSL
//
