ID A0A2I3TQR9_PANTR Unreviewed; 748 AA.
AC A0A2I3TQR9; A0A2J8QHX1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Rho GTPase activating protein 33 {ECO:0000313|Ensembl:ENSPTRP00000091552.1};
GN Name=ARHGAP33 {ECO:0000313|Ensembl:ENSPTRP00000091552.1,
GN ECO:0000313|VGNC:VGNC:11222};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000091552.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000091552.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000091552.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PX domain-containing GAP family.
CC {ECO:0000256|ARBA:ARBA00008795}.
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DR EMBL; AACZ04019751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3TQR9; -.
DR SMR; A0A2I3TQR9; -.
DR Ensembl; ENSPTRT00000098159.1; ENSPTRP00000091552.1; ENSPTRG00000010866.6.
DR VGNC; VGNC:11222; ARHGAP33.
DR GeneTree; ENSGT00940000155110; -.
DR Proteomes; UP000002277; Chromosome 19.
DR Bgee; ENSPTRG00000010866; Expressed in superior frontal gyrus and 16 other cell types or tissues.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07299; PX_TCGAP; 1.
DR CDD; cd04384; RhoGAP_CdGAP; 1.
DR CDD; cd11835; SH3_ARHGAP32_33; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15729; CDC42 GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15729:SF11; RHO GTPASE-ACTIVATING PROTEIN 33; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 186..248
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 315..510
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..714
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 748 AA; 81473 MW; 3ADF5B3A34267061 CRC64;
MVARSTDSLD GPGEGSVQPL PTAGGPSVKG KPGKRLSAPR GPFPRLADCA HFHYENVDFG
HIQLLLSPDR EGPSLSGENE LVFGVQVTCQ GRSWPVLRSY DDFRSLDAHL HRCIFDRRFS
CLPELPPPPE GARAAQMLVP LLLQYLETLS GLVDSNLNCG PVLTWMELDN HGRRLLLSEE
ASLNIPAVAA AHVIKRYTAQ APDELSFEVG DIVSVIDMPP TEDRSWWRGK RGFQVGFFPS
ECVELFTERP GPGLKADADG PPCGIPAPQG ISSLTSAVPR PRGKLAGLLR TFMRSRPSRQ
RLRQRGILRQ RVFGCDLGEH LSNSGQDVPQ VLRCCSEFIE AHGVVDGIYR LSGVSSNIQR
LRHEFDSERI PELSGPAFLQ DIHSVSSLCK LYFRELPNPL LTYQLYGKFS EAMSVPGEEE
RLVRVHDVIQ QLPPPHYRTL EYLLRHLARM ARHSANTSMH ARNLAIVWAP NLLRSMELES
VGMGGAAAFR EVRVQSVVVE FLLTHVDVLF SDTFTSAGLD PAGRCLLPRP KSLAGSCPST
RLLTLEEAQA RTQGRLGTPT EPTTPKAPAS PAERRKGERG EKQRKPGGSS WKTFFALGRG
PSVPRKKPLP WLGGTRAPPQ PSGSRPDTVT LRSAKSEESL SSQASGAGLQ RLHRLRRPHS
SSDAFPVGPA PAGSCESLSS SSSSESSSSE SSSSSSESSA AGLGALSGSP SHRTSAWLDD
GDELDFSPPR YPTPSWSLHS EGQTRSYC
//
