ID A0A2I3TTI2_PANTR Unreviewed; 1021 AA.
AC A0A2I3TTI2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=RAB44, member RAS onco family {ECO:0000313|Ensembl:ENSPTRP00000092575.1};
GN Name=RAB44 {ECO:0000313|Ensembl:ENSPTRP00000092575.1,
GN ECO:0000313|VGNC:VGNC:57536};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000092575.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000092575.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000092575.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04022835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3TTI2; -.
DR PaxDb; 9598-ENSPTRP00000030933; -.
DR Ensembl; ENSPTRT00000081620.1; ENSPTRP00000092575.1; ENSPTRG00000045813.1.
DR VGNC; VGNC:57536; RAB44.
DR GeneTree; ENSGT00940000160379; -.
DR InParanoid; A0A2I3TTI2; -.
DR OMA; SEMIFDW; -.
DR Proteomes; UP000002277; Chromosome 6.
DR Bgee; ENSPTRG00000045813; Expressed in bone marrow and 5 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0002553; P:histamine secretion by mast cell; IEA:Ensembl.
DR GO; GO:0097279; P:histamine secretion mediated by IgE immunoglobulin; IEA:Ensembl.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR CDD; cd00154; Rab; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR47977; RAS-RELATED PROTEIN RAB; 1.
DR PANTHER; PTHR47977:SF72; RAS-RELATED PROTEIN RAB-44; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00177; ARF; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS51420; RHO; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 77..112
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 191..315
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 400..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..465
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..513
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..701
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..807
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1021 AA; 110841 MW; B7C9B677505ABA39 CRC64;
METGQRTSRK VRKLGSNRRR QTREPADGED AAVAPEPESW SSQAAAELQA FFQDCGAKER
GFVTREDLAV AKFSFLGSKE ESEMIFDWVD VERKGHLSLE EFSSGLKNIF GSSQSPHRLR
RRKPLPSKRV SATTSFPALE EADAEEKEAF LAFMEQLGTG HLLPKQTEIW QLWGQLRQEE
PQLAGNLAGF LAKMTSRLQE AQADKEALEL TLRKRDSDHH REVQQLYEEM EQQIRQEKQQ
LQAESDSRGL ALTSQMQDVL EAKEREVQRL AEGQRELEAQ LSHLRSTHQE AASENQQLQE
AKRDLAGRLE EVRGQLQVTR GRLDAARGRV SWQVEEKLSF PGAGEKTPDP QAASPEEAPL
PGLFGDNDDW DQLLSNFGSP PHGALQLCWS PPPTPRATSG PQTPRVVRQI SISEPQAFLF
GQEPSSDPDG APRTPPGVTF SAKDNKGVDP DEQDIRAEQP VEPHDPDPNQ EPGSTPEGRL
LWGLSGSLVA PAFKVLIPLE DGPPPPANSP PPQAPAGSSK QIQASDPDDK GPGSWAPPSG
AQPGAGAGPR EPTQTPPTMT ERETQPGPSP TTALTGVGPA KPPRQRDALQ QDLHATGSEP
RLGTQRARAL TLGPAEPFQS LEFVGPVPTE RLEQGQAGPA VQEGLPEGLR EAHGQVLGLG
ELPAFPHQGL EEEPRSEEGK QEGRGGQDLS SEQSEQSVEA HGLETAHSEL PQQDSLLVSL
PSATPQAQVE AEGPTPGKSA PPRGSPPGGA QPGAGAGPQE PTQTPPTMAE QEAQPRPSLT
TAHAEEQGPP HSREPRAESR LEDPGMDSRE AGLTPSLGDP MAEGGPQANP DYLFHVIFLG
DSNVGKTSFL HLLHQNSFAT GLTATVGVDF RVKTLLVDNK CFVLQLWDTA GQERYHSMTR
QLLRKADGVV LMYDITSQES FAHVRYWLDC LQDAGSDGVV ILLLGNKMDC EEERQVSVEA
GQQLAQELGV YFGECSAALG HNILEPVVNL ARSLRMQEEG LKDSLVKVAP KRPPKRFGCC
S
//
